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The Diagnostic, Therapeutic and Prognostic Relevance of Neutrophil Extracellular Traps in Polytrauma
Neutrophil extracellular traps (NETs) represent a recently discovered polymorphonuclear leukocyte-associated ancient defence mechanism, and they have also been identified as part of polytrauma patients’ sterile inflammatory response. This systematic review aimed to determine the clinical significanc...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669581/ https://www.ncbi.nlm.nih.gov/pubmed/38002307 http://dx.doi.org/10.3390/biom13111625 |
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author | Rogers, Emily Pothugunta, Shevani Kosmider, Veronika Stokes, Natasha Bonomini, Layla Briggs, Gabrielle D. Lewis, Daniel P. Balogh, Zsolt J. |
author_facet | Rogers, Emily Pothugunta, Shevani Kosmider, Veronika Stokes, Natasha Bonomini, Layla Briggs, Gabrielle D. Lewis, Daniel P. Balogh, Zsolt J. |
author_sort | Rogers, Emily |
collection | PubMed |
description | Neutrophil extracellular traps (NETs) represent a recently discovered polymorphonuclear leukocyte-associated ancient defence mechanism, and they have also been identified as part of polytrauma patients’ sterile inflammatory response. This systematic review aimed to determine the clinical significance of NETs in polytrauma, focusing on potential prognostic, diagnostic and therapeutic relevance. The methodology covered all major databases and all study types, but was restricted to polytraumatised humans. Fourteen studies met the inclusion criteria, reporting on 1967 patients. Ten samples were taken from plasma and four from whole blood. There was no standardisation of methodology of NET detection among plasma studies; however, of all the papers that included a healthy control NET, proxies were increased. Polytrauma patients were consistently reported to have higher concentrations of NET markers in peripheral blood than those in healthy controls, but their diagnostic, therapeutic and prognostic utility is equivocal due to the diverse study population and methodology. After 20 years since the discovery of NETs, their natural history and potential clinical utility in polytrauma is undetermined, requiring further standardisation and research. |
format | Online Article Text |
id | pubmed-10669581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106695812023-11-07 The Diagnostic, Therapeutic and Prognostic Relevance of Neutrophil Extracellular Traps in Polytrauma Rogers, Emily Pothugunta, Shevani Kosmider, Veronika Stokes, Natasha Bonomini, Layla Briggs, Gabrielle D. Lewis, Daniel P. Balogh, Zsolt J. Biomolecules Systematic Review Neutrophil extracellular traps (NETs) represent a recently discovered polymorphonuclear leukocyte-associated ancient defence mechanism, and they have also been identified as part of polytrauma patients’ sterile inflammatory response. This systematic review aimed to determine the clinical significance of NETs in polytrauma, focusing on potential prognostic, diagnostic and therapeutic relevance. The methodology covered all major databases and all study types, but was restricted to polytraumatised humans. Fourteen studies met the inclusion criteria, reporting on 1967 patients. Ten samples were taken from plasma and four from whole blood. There was no standardisation of methodology of NET detection among plasma studies; however, of all the papers that included a healthy control NET, proxies were increased. Polytrauma patients were consistently reported to have higher concentrations of NET markers in peripheral blood than those in healthy controls, but their diagnostic, therapeutic and prognostic utility is equivocal due to the diverse study population and methodology. After 20 years since the discovery of NETs, their natural history and potential clinical utility in polytrauma is undetermined, requiring further standardisation and research. MDPI 2023-11-07 /pmc/articles/PMC10669581/ /pubmed/38002307 http://dx.doi.org/10.3390/biom13111625 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Rogers, Emily Pothugunta, Shevani Kosmider, Veronika Stokes, Natasha Bonomini, Layla Briggs, Gabrielle D. Lewis, Daniel P. Balogh, Zsolt J. The Diagnostic, Therapeutic and Prognostic Relevance of Neutrophil Extracellular Traps in Polytrauma |
title | The Diagnostic, Therapeutic and Prognostic Relevance of Neutrophil Extracellular Traps in Polytrauma |
title_full | The Diagnostic, Therapeutic and Prognostic Relevance of Neutrophil Extracellular Traps in Polytrauma |
title_fullStr | The Diagnostic, Therapeutic and Prognostic Relevance of Neutrophil Extracellular Traps in Polytrauma |
title_full_unstemmed | The Diagnostic, Therapeutic and Prognostic Relevance of Neutrophil Extracellular Traps in Polytrauma |
title_short | The Diagnostic, Therapeutic and Prognostic Relevance of Neutrophil Extracellular Traps in Polytrauma |
title_sort | diagnostic, therapeutic and prognostic relevance of neutrophil extracellular traps in polytrauma |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669581/ https://www.ncbi.nlm.nih.gov/pubmed/38002307 http://dx.doi.org/10.3390/biom13111625 |
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