Cargando…

APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation of the gastrointestinal tract. The prevalence of IBD is increasing with approximately 4.9 million cases reported worldwide. Current therapies are limited due to the severity of side effects and long-term toxicity, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sahakian, Lauren, Robinson, Ainsley M., Sahakian, Linda, Stavely, Rhian, Kelley, Mark R., Nurgali, Kulmira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669584/ https://www.ncbi.nlm.nih.gov/pubmed/38002251 http://dx.doi.org/10.3390/biom13111569

Ejemplares similares

Oxidative Stress-Induced HMGB1 Translocation in Myenteric Neurons Contributes to Neuropathy in Colitis
por: Stavely, Rhian, et al.
Publicado: (2022)

The emerging antioxidant paradigm of mesenchymal stem cell therapy
por: Stavely, Rhian, et al.
Publicado: (2020)

Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
por: Craig, Colin F., et al.
Publicado: (2022)

Human adult stem cells derived from adipose tissue and bone marrow attenuate enteric neuropathy in the guinea-pig model of acute colitis
por: Stavely, Rhian, et al.
Publicado: (2015)

Allogeneic guinea pig mesenchymal stem cells ameliorate neurological changes in experimental colitis
por: Stavely, Rhian, et al.
Publicado: (2015)

The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis
por: Robinson, Ainsley M., et al.
Publicado: (2017)

APE1/Ref-1 as a Novel Target for Retinal Diseases
por: Heisel, Curtis, et al.
Publicado: (2021)

Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein
por: Choi, Sunga, et al.
Publicado: (2016)

APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival
por: Cardoso, Angelo A., et al.
Publicado: (2012)

APE1/Ref-1 – One Target with Multiple Indications: Emerging Aspects and New Directions
por: Mijit, Mahmut, et al.
Publicado: (2021)

Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy
por: Hartman, Gabriella D., et al.
Publicado: (2021)

The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders
por: Stavely, Rhian, et al.
Publicado: (2023)

APE1/Ref-1 Role in Inflammation and Immune Response
por: Oliveira, Thais Teixeira, et al.
Publicado: (2022)

Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells
por: Mijit, Mahmut, et al.
Publicado: (2023)

APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions
por: Thakur, Shweta, et al.
Publicado: (2014)

Oxaliplatin-Induced Damage to the Gastric Innervation: Role in Nausea and Vomiting
por: Rahman, Ahmed A., et al.
Publicado: (2023)

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic
por: Shah, Fenil, et al.
Publicado: (2017)

Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis
por: Jin, Seon-Ah, et al.
Publicado: (2017)

DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents
por: Raffoul, Julian J., et al.
Publicado: (2012)

The role of APE/Ref-1 signaling pathway in hepatocellular carcinoma progression
por: YANG, ZHEN, et al.
Publicado: (2014)

Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker
por: Choi, Sunga, et al.
Publicado: (2016)

APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer
por: Shin, Ju Hyun, et al.
Publicado: (2015)

Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
por: Pines, Alex, et al.
Publicado: (2005)

New Horizons for the Roles and Association of APE1/Ref-1 and ABCA1 in Atherosclerosis
por: Chen, Wujun, et al.
Publicado: (2021)

Differential Gene Expression of Checkpoint Markers and Cancer Markers in Mouse Models of Spontaneous Chronic Colitis
por: Ephraim, Ramya, et al.
Publicado: (2023)

Plasma APE1/Ref-1 Correlates with Atherosclerotic Inflammation in ApoE(−/−) Mice
por: Lee, Yu Ran, et al.
Publicado: (2020)

Bis-Cinnamamide Derivatives as APE/Ref-1 Inhibitors for the Treatment of Human Melanoma
por: Alhazmi, Razan, et al.
Publicado: (2022)

Oxaliplatin-induced changes in microbiota, TLR4+ cells and enhanced HMGB1 expression in the murine colon
por: Stojanovska, Vanesa, et al.
Publicado: (2018)

Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides
por: Lau, J P, et al.
Publicado: (2004)

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1)
por: Jackson, Elias B., et al.
Publicado: (2005)

Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor
por: Qian, Chengyuan, et al.
Publicado: (2014)

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function
por: Vascotto, Carlo, et al.
Publicado: (2011)

APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells
por: McIlwain, David W., et al.
Publicado: (2017)

Dual Function of Secreted APE1/Ref-1 in TNBC Tumorigenesis: An Apoptotic Initiator and a Regulator of Chronic Inflammatory Signaling
por: Choi, Sunga, et al.
Publicado: (2022)

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival
por: Logsdon, Derek P., et al.
Publicado: (2018)

Therapeutic positioning of secretory acetylated APE1/Ref-1 requirement for suppression of tumor growth in triple-negative breast cancer in vivo
por: Lee, Yu Ran, et al.
Publicado: (2018)

ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1
por: Lee, Yu Ran, et al.
Publicado: (2019)

APE1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencing
por: Shah, Fenil, et al.
Publicado: (2017)

Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of Cysteines 93 and 310
por: Qu, Jing, et al.
Publicado: (2007)

Elevated APE1/Ref-1 Levels of Synovial Fluids in Patients with Rheumatoid Arthritis: Reflection of Disease Activity
por: Yoo, In Seol, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1e7k5evrhhjgep12qflabg5hc8