Cargando…
Research Progress of Titanium-Based Alloys for Medical Devices
Biomaterials are currently a unique class of materials that are essential to improving the standard of human life and extending it. In the assent of the appearance of biomaterials that contain non-toxic elements, in this study, we examine a system of Ti25Mo7Zr15TaxSi (x = 0, 0.5, 0.75, 1 wt.%) for f...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669585/ https://www.ncbi.nlm.nih.gov/pubmed/38001997 http://dx.doi.org/10.3390/biomedicines11112997 |
_version_ | 1785139731131006976 |
---|---|
author | Baltatu, Madalina Simona Vizureanu, Petrica Sandu, Andrei Victor Solcan, Carmen Hritcu, Luminița Diana Spataru, Mihaela Claudia |
author_facet | Baltatu, Madalina Simona Vizureanu, Petrica Sandu, Andrei Victor Solcan, Carmen Hritcu, Luminița Diana Spataru, Mihaela Claudia |
author_sort | Baltatu, Madalina Simona |
collection | PubMed |
description | Biomaterials are currently a unique class of materials that are essential to improving the standard of human life and extending it. In the assent of the appearance of biomaterials that contain non-toxic elements, in this study, we examine a system of Ti25Mo7Zr15TaxSi (x = 0, 0.5, 0.75, 1 wt.%) for future medical applications. The alloys were developed in a vacuum electric arc furnace and then studied from a structural, mechanical and in vivo assessment (on rabbits) perspective. The effect of the silicon addition was clearly seen in both the structural and the mechanical characteristics, standing out as beta alloys with a dendritic structure and lowering the mechanical properties as a result of the silicon addition. In experimental rabbits, the proliferation of mesenchymal stem cells was observed in the periosteum and peri-implant area, differentiating into osteoblasts and then into osteocytes. Osteoclasts were discovered within the cartilaginous islands that provide structural support to newly formed bone, playing a primary role in bone remodeling. The newly formed spongy tissue adhered to the fibrous capsule that surrounds the alloy, ensuring good osseointegration of metallic implants. The overexpression of Osteopontin, Metalloproteinase-2 (also known as gelatinase A), and Metallopeptidase-9 (also known as gelatinase B) underscores the processes of osteogenesis, bone mineralization, and normal bone remodeling. |
format | Online Article Text |
id | pubmed-10669585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106695852023-11-08 Research Progress of Titanium-Based Alloys for Medical Devices Baltatu, Madalina Simona Vizureanu, Petrica Sandu, Andrei Victor Solcan, Carmen Hritcu, Luminița Diana Spataru, Mihaela Claudia Biomedicines Article Biomaterials are currently a unique class of materials that are essential to improving the standard of human life and extending it. In the assent of the appearance of biomaterials that contain non-toxic elements, in this study, we examine a system of Ti25Mo7Zr15TaxSi (x = 0, 0.5, 0.75, 1 wt.%) for future medical applications. The alloys were developed in a vacuum electric arc furnace and then studied from a structural, mechanical and in vivo assessment (on rabbits) perspective. The effect of the silicon addition was clearly seen in both the structural and the mechanical characteristics, standing out as beta alloys with a dendritic structure and lowering the mechanical properties as a result of the silicon addition. In experimental rabbits, the proliferation of mesenchymal stem cells was observed in the periosteum and peri-implant area, differentiating into osteoblasts and then into osteocytes. Osteoclasts were discovered within the cartilaginous islands that provide structural support to newly formed bone, playing a primary role in bone remodeling. The newly formed spongy tissue adhered to the fibrous capsule that surrounds the alloy, ensuring good osseointegration of metallic implants. The overexpression of Osteopontin, Metalloproteinase-2 (also known as gelatinase A), and Metallopeptidase-9 (also known as gelatinase B) underscores the processes of osteogenesis, bone mineralization, and normal bone remodeling. MDPI 2023-11-08 /pmc/articles/PMC10669585/ /pubmed/38001997 http://dx.doi.org/10.3390/biomedicines11112997 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Baltatu, Madalina Simona Vizureanu, Petrica Sandu, Andrei Victor Solcan, Carmen Hritcu, Luminița Diana Spataru, Mihaela Claudia Research Progress of Titanium-Based Alloys for Medical Devices |
title | Research Progress of Titanium-Based Alloys for Medical Devices |
title_full | Research Progress of Titanium-Based Alloys for Medical Devices |
title_fullStr | Research Progress of Titanium-Based Alloys for Medical Devices |
title_full_unstemmed | Research Progress of Titanium-Based Alloys for Medical Devices |
title_short | Research Progress of Titanium-Based Alloys for Medical Devices |
title_sort | research progress of titanium-based alloys for medical devices |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669585/ https://www.ncbi.nlm.nih.gov/pubmed/38001997 http://dx.doi.org/10.3390/biomedicines11112997 |
work_keys_str_mv | AT baltatumadalinasimona researchprogressoftitaniumbasedalloysformedicaldevices AT vizureanupetrica researchprogressoftitaniumbasedalloysformedicaldevices AT sanduandreivictor researchprogressoftitaniumbasedalloysformedicaldevices AT solcancarmen researchprogressoftitaniumbasedalloysformedicaldevices AT hritculuminitadiana researchprogressoftitaniumbasedalloysformedicaldevices AT spatarumihaelaclaudia researchprogressoftitaniumbasedalloysformedicaldevices |