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Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds
The complex process of bone regeneration is influenced by factors such as inflammatory responses, tissue interactions, and progenitor cells. Currently, multiple traumas can interfere with fracture healing, causing the prolonging or failure of healing. In these cases, bone grafting is the most effect...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669612/ https://www.ncbi.nlm.nih.gov/pubmed/38002434 http://dx.doi.org/10.3390/bioengineering10111311 |
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author | Yun, Hyun-Ho Kim, Seong-Gon Park, Se-Il Jo, Woori Kang, Kyung-Ku Lee, Eun-Joo Kim, Dong-Kyu Jung, Hoe-Su Son, Ji-Yoon Park, Jae-Min Park, Hyun-Sook Lee, Sunray Shin, Hong-In Hong, Il-Hwa Jeong, Kyu-Shik |
author_facet | Yun, Hyun-Ho Kim, Seong-Gon Park, Se-Il Jo, Woori Kang, Kyung-Ku Lee, Eun-Joo Kim, Dong-Kyu Jung, Hoe-Su Son, Ji-Yoon Park, Jae-Min Park, Hyun-Sook Lee, Sunray Shin, Hong-In Hong, Il-Hwa Jeong, Kyu-Shik |
author_sort | Yun, Hyun-Ho |
collection | PubMed |
description | The complex process of bone regeneration is influenced by factors such as inflammatory responses, tissue interactions, and progenitor cells. Currently, multiple traumas can interfere with fracture healing, causing the prolonging or failure of healing. In these cases, bone grafting is the most effective treatment. However, there are several drawbacks, such as morbidity at the donor site and availability of suitable materials. Advantages have been provided in this field by a variety of stem cell types. Adipose-derived stem cells (ASCs) show promise. In the radiological examination of this study, it was confirmed that the C/S group showed faster regeneration than the other groups, and Micro-CT also showed that the degree of bone formation in the defect area was highest in the C/S group. Compared to the control group, the change in cortical bone area in the defect area decreased in the sham group (0.874), while it slightly increased in the C/S group (1.027). An increase in relative vascularity indicates a decrease in overall bone density, but a weak depression filled with fibrous tissue was observed outside the compact bone. It was confirmed that newly formed cortical bone showed a slight difference in bone density compared to surrounding normal bone tissue due to increased distribution of cortical bone. In this study, we investigated the effect of bone regeneration by ADMSCs measured by radiation and pathological effects. These data can ultimately be applied to humans with important clinical applications in various bone diseases, regenerative, and early stages of formative differentiation. |
format | Online Article Text |
id | pubmed-10669612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106696122023-11-13 Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds Yun, Hyun-Ho Kim, Seong-Gon Park, Se-Il Jo, Woori Kang, Kyung-Ku Lee, Eun-Joo Kim, Dong-Kyu Jung, Hoe-Su Son, Ji-Yoon Park, Jae-Min Park, Hyun-Sook Lee, Sunray Shin, Hong-In Hong, Il-Hwa Jeong, Kyu-Shik Bioengineering (Basel) Article The complex process of bone regeneration is influenced by factors such as inflammatory responses, tissue interactions, and progenitor cells. Currently, multiple traumas can interfere with fracture healing, causing the prolonging or failure of healing. In these cases, bone grafting is the most effective treatment. However, there are several drawbacks, such as morbidity at the donor site and availability of suitable materials. Advantages have been provided in this field by a variety of stem cell types. Adipose-derived stem cells (ASCs) show promise. In the radiological examination of this study, it was confirmed that the C/S group showed faster regeneration than the other groups, and Micro-CT also showed that the degree of bone formation in the defect area was highest in the C/S group. Compared to the control group, the change in cortical bone area in the defect area decreased in the sham group (0.874), while it slightly increased in the C/S group (1.027). An increase in relative vascularity indicates a decrease in overall bone density, but a weak depression filled with fibrous tissue was observed outside the compact bone. It was confirmed that newly formed cortical bone showed a slight difference in bone density compared to surrounding normal bone tissue due to increased distribution of cortical bone. In this study, we investigated the effect of bone regeneration by ADMSCs measured by radiation and pathological effects. These data can ultimately be applied to humans with important clinical applications in various bone diseases, regenerative, and early stages of formative differentiation. MDPI 2023-11-13 /pmc/articles/PMC10669612/ /pubmed/38002434 http://dx.doi.org/10.3390/bioengineering10111311 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yun, Hyun-Ho Kim, Seong-Gon Park, Se-Il Jo, Woori Kang, Kyung-Ku Lee, Eun-Joo Kim, Dong-Kyu Jung, Hoe-Su Son, Ji-Yoon Park, Jae-Min Park, Hyun-Sook Lee, Sunray Shin, Hong-In Hong, Il-Hwa Jeong, Kyu-Shik Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds |
title | Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds |
title_full | Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds |
title_fullStr | Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds |
title_full_unstemmed | Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds |
title_short | Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds |
title_sort | early osteogenic-induced adipose-derived stem cells and canine bone regeneration potential analyzed using biodegradable scaffolds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669612/ https://www.ncbi.nlm.nih.gov/pubmed/38002434 http://dx.doi.org/10.3390/bioengineering10111311 |
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