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Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns

Background: NT-proBNP (N-terminal pro-brain natriuretic peptide) has a high negative predictive value for ruling out heart failure, a disorder linked with volume overload of the ventricles, and is used for diagnosis, prognosis, and risk stratification. Pregnancy causes in healthy women changes in ph...

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Autores principales: Marta, Carmen-Ioana, Craina, Marius, Nitu, Razvan, Maghiari, Anca Laura, Abu-Awwad, Simona-Alina, Boscu, Lioara, Diaconu, Mircea, Dumitru, Catalin, Sorop, Bogdan, Stelea, Lavinia, Babes, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669629/
https://www.ncbi.nlm.nih.gov/pubmed/38001965
http://dx.doi.org/10.3390/biomedicines11112964
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author Marta, Carmen-Ioana
Craina, Marius
Nitu, Razvan
Maghiari, Anca Laura
Abu-Awwad, Simona-Alina
Boscu, Lioara
Diaconu, Mircea
Dumitru, Catalin
Sorop, Bogdan
Stelea, Lavinia
Babes, Katalin
author_facet Marta, Carmen-Ioana
Craina, Marius
Nitu, Razvan
Maghiari, Anca Laura
Abu-Awwad, Simona-Alina
Boscu, Lioara
Diaconu, Mircea
Dumitru, Catalin
Sorop, Bogdan
Stelea, Lavinia
Babes, Katalin
author_sort Marta, Carmen-Ioana
collection PubMed
description Background: NT-proBNP (N-terminal pro-brain natriuretic peptide) has a high negative predictive value for ruling out heart failure, a disorder linked with volume overload of the ventricles, and is used for diagnosis, prognosis, and risk stratification. Pregnancy causes in healthy women changes in physical and hemodynamic parameters and appears to be a risk factor for severe COVID-19 illness. The purpose of this study is to highlight the significance of monitoring NT-proBNP levels during pregnancy, particularly in patients who were infected with COVID-19 during pregnancy or were infected with the virus while giving birth. The findings of this comparative research indicate the importance of NT-proBNP in terms of foetal prognosis and birthweight. Methods: We collected blood samples to measure NT-proBNP concentrations from a cohort of 186 pregnant patients divided into two groups based on the presence of SARS-CoV-2 viral infection. Results: Elevated NT-proBNP had an unfavourable implication on the newborn birth weight and Apgar score and expressed its influence on lower values. Conclusions: We consider that NT-proBNP testing in pregnant patients, especially those with COVID-19 infection, can be relevant and be used as a predictive marker to be taken into consideration when it comes to management, outcome, and treatment regarding pregnant patients and their newborns.
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spelling pubmed-106696292023-11-02 Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns Marta, Carmen-Ioana Craina, Marius Nitu, Razvan Maghiari, Anca Laura Abu-Awwad, Simona-Alina Boscu, Lioara Diaconu, Mircea Dumitru, Catalin Sorop, Bogdan Stelea, Lavinia Babes, Katalin Biomedicines Article Background: NT-proBNP (N-terminal pro-brain natriuretic peptide) has a high negative predictive value for ruling out heart failure, a disorder linked with volume overload of the ventricles, and is used for diagnosis, prognosis, and risk stratification. Pregnancy causes in healthy women changes in physical and hemodynamic parameters and appears to be a risk factor for severe COVID-19 illness. The purpose of this study is to highlight the significance of monitoring NT-proBNP levels during pregnancy, particularly in patients who were infected with COVID-19 during pregnancy or were infected with the virus while giving birth. The findings of this comparative research indicate the importance of NT-proBNP in terms of foetal prognosis and birthweight. Methods: We collected blood samples to measure NT-proBNP concentrations from a cohort of 186 pregnant patients divided into two groups based on the presence of SARS-CoV-2 viral infection. Results: Elevated NT-proBNP had an unfavourable implication on the newborn birth weight and Apgar score and expressed its influence on lower values. Conclusions: We consider that NT-proBNP testing in pregnant patients, especially those with COVID-19 infection, can be relevant and be used as a predictive marker to be taken into consideration when it comes to management, outcome, and treatment regarding pregnant patients and their newborns. MDPI 2023-11-02 /pmc/articles/PMC10669629/ /pubmed/38001965 http://dx.doi.org/10.3390/biomedicines11112964 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marta, Carmen-Ioana
Craina, Marius
Nitu, Razvan
Maghiari, Anca Laura
Abu-Awwad, Simona-Alina
Boscu, Lioara
Diaconu, Mircea
Dumitru, Catalin
Sorop, Bogdan
Stelea, Lavinia
Babes, Katalin
Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns
title Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns
title_full Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns
title_fullStr Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns
title_full_unstemmed Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns
title_short Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns
title_sort variations in nt-probnp levels in pregnant patients with and without sars-cov-2 infection: consequences for the newborns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669629/
https://www.ncbi.nlm.nih.gov/pubmed/38001965
http://dx.doi.org/10.3390/biomedicines11112964
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