Cargando…

Chorioamnionitis: An Update on Diagnostic Evaluation

Chorioamnionitis remains a major cause of preterm birth and maternal and neonatal morbidity. We reviewed the current evidence for the diagnostic tests of chorioamnionitis and how this relates to clinical practice today. A comprehensive literature search and review was conducted on chorioamnionitis a...

Descripción completa

Detalles Bibliográficos
Autores principales: Carter, Sean W. D., Neubronner, Samantha, Su, Lin Lin, Dashraath, Pradip, Mattar, Citra, Illanes, Sebastián E., Choolani, Mahesh A., Kemp, Matthew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669668/
https://www.ncbi.nlm.nih.gov/pubmed/38001923
http://dx.doi.org/10.3390/biomedicines11112922
_version_ 1785139750587334656
author Carter, Sean W. D.
Neubronner, Samantha
Su, Lin Lin
Dashraath, Pradip
Mattar, Citra
Illanes, Sebastián E.
Choolani, Mahesh A.
Kemp, Matthew W.
author_facet Carter, Sean W. D.
Neubronner, Samantha
Su, Lin Lin
Dashraath, Pradip
Mattar, Citra
Illanes, Sebastián E.
Choolani, Mahesh A.
Kemp, Matthew W.
author_sort Carter, Sean W. D.
collection PubMed
description Chorioamnionitis remains a major cause of preterm birth and maternal and neonatal morbidity. We reviewed the current evidence for the diagnostic tests of chorioamnionitis and how this relates to clinical practice today. A comprehensive literature search and review was conducted on chorioamnionitis and intra-uterine inflammation. Data from randomized control trials and systematic reviews were prioritized. This review highlights that sterile inflammation plays an important role in chorioamnionitis and that the current tests for chorioamnionitis including clinical criteria, maternal plasma and vaginal biomarkers lack diagnostic accuracy. Concerningly, these tests often rely on detecting an inflammatory response after damage has occurred to the fetus. Care should be taken when interpreting current investigations for the diagnosis of chorioamnionitis and how they guide obstetric/neonatal management. There is an urgent need for further validation of current diagnostic tests and the development of novel, accurate, minimally invasive tests that detect subclinical intra-uterine inflammation.
format Online
Article
Text
id pubmed-10669668
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106696682023-10-28 Chorioamnionitis: An Update on Diagnostic Evaluation Carter, Sean W. D. Neubronner, Samantha Su, Lin Lin Dashraath, Pradip Mattar, Citra Illanes, Sebastián E. Choolani, Mahesh A. Kemp, Matthew W. Biomedicines Review Chorioamnionitis remains a major cause of preterm birth and maternal and neonatal morbidity. We reviewed the current evidence for the diagnostic tests of chorioamnionitis and how this relates to clinical practice today. A comprehensive literature search and review was conducted on chorioamnionitis and intra-uterine inflammation. Data from randomized control trials and systematic reviews were prioritized. This review highlights that sterile inflammation plays an important role in chorioamnionitis and that the current tests for chorioamnionitis including clinical criteria, maternal plasma and vaginal biomarkers lack diagnostic accuracy. Concerningly, these tests often rely on detecting an inflammatory response after damage has occurred to the fetus. Care should be taken when interpreting current investigations for the diagnosis of chorioamnionitis and how they guide obstetric/neonatal management. There is an urgent need for further validation of current diagnostic tests and the development of novel, accurate, minimally invasive tests that detect subclinical intra-uterine inflammation. MDPI 2023-10-28 /pmc/articles/PMC10669668/ /pubmed/38001923 http://dx.doi.org/10.3390/biomedicines11112922 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Carter, Sean W. D.
Neubronner, Samantha
Su, Lin Lin
Dashraath, Pradip
Mattar, Citra
Illanes, Sebastián E.
Choolani, Mahesh A.
Kemp, Matthew W.
Chorioamnionitis: An Update on Diagnostic Evaluation
title Chorioamnionitis: An Update on Diagnostic Evaluation
title_full Chorioamnionitis: An Update on Diagnostic Evaluation
title_fullStr Chorioamnionitis: An Update on Diagnostic Evaluation
title_full_unstemmed Chorioamnionitis: An Update on Diagnostic Evaluation
title_short Chorioamnionitis: An Update on Diagnostic Evaluation
title_sort chorioamnionitis: an update on diagnostic evaluation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669668/
https://www.ncbi.nlm.nih.gov/pubmed/38001923
http://dx.doi.org/10.3390/biomedicines11112922
work_keys_str_mv AT carterseanwd chorioamnionitisanupdateondiagnosticevaluation
AT neubronnersamantha chorioamnionitisanupdateondiagnosticevaluation
AT sulinlin chorioamnionitisanupdateondiagnosticevaluation
AT dashraathpradip chorioamnionitisanupdateondiagnosticevaluation
AT mattarcitra chorioamnionitisanupdateondiagnosticevaluation
AT illanessebastiane chorioamnionitisanupdateondiagnosticevaluation
AT choolanimahesha chorioamnionitisanupdateondiagnosticevaluation
AT kempmattheww chorioamnionitisanupdateondiagnosticevaluation