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Chorioamnionitis: An Update on Diagnostic Evaluation
Chorioamnionitis remains a major cause of preterm birth and maternal and neonatal morbidity. We reviewed the current evidence for the diagnostic tests of chorioamnionitis and how this relates to clinical practice today. A comprehensive literature search and review was conducted on chorioamnionitis a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669668/ https://www.ncbi.nlm.nih.gov/pubmed/38001923 http://dx.doi.org/10.3390/biomedicines11112922 |
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author | Carter, Sean W. D. Neubronner, Samantha Su, Lin Lin Dashraath, Pradip Mattar, Citra Illanes, Sebastián E. Choolani, Mahesh A. Kemp, Matthew W. |
author_facet | Carter, Sean W. D. Neubronner, Samantha Su, Lin Lin Dashraath, Pradip Mattar, Citra Illanes, Sebastián E. Choolani, Mahesh A. Kemp, Matthew W. |
author_sort | Carter, Sean W. D. |
collection | PubMed |
description | Chorioamnionitis remains a major cause of preterm birth and maternal and neonatal morbidity. We reviewed the current evidence for the diagnostic tests of chorioamnionitis and how this relates to clinical practice today. A comprehensive literature search and review was conducted on chorioamnionitis and intra-uterine inflammation. Data from randomized control trials and systematic reviews were prioritized. This review highlights that sterile inflammation plays an important role in chorioamnionitis and that the current tests for chorioamnionitis including clinical criteria, maternal plasma and vaginal biomarkers lack diagnostic accuracy. Concerningly, these tests often rely on detecting an inflammatory response after damage has occurred to the fetus. Care should be taken when interpreting current investigations for the diagnosis of chorioamnionitis and how they guide obstetric/neonatal management. There is an urgent need for further validation of current diagnostic tests and the development of novel, accurate, minimally invasive tests that detect subclinical intra-uterine inflammation. |
format | Online Article Text |
id | pubmed-10669668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106696682023-10-28 Chorioamnionitis: An Update on Diagnostic Evaluation Carter, Sean W. D. Neubronner, Samantha Su, Lin Lin Dashraath, Pradip Mattar, Citra Illanes, Sebastián E. Choolani, Mahesh A. Kemp, Matthew W. Biomedicines Review Chorioamnionitis remains a major cause of preterm birth and maternal and neonatal morbidity. We reviewed the current evidence for the diagnostic tests of chorioamnionitis and how this relates to clinical practice today. A comprehensive literature search and review was conducted on chorioamnionitis and intra-uterine inflammation. Data from randomized control trials and systematic reviews were prioritized. This review highlights that sterile inflammation plays an important role in chorioamnionitis and that the current tests for chorioamnionitis including clinical criteria, maternal plasma and vaginal biomarkers lack diagnostic accuracy. Concerningly, these tests often rely on detecting an inflammatory response after damage has occurred to the fetus. Care should be taken when interpreting current investigations for the diagnosis of chorioamnionitis and how they guide obstetric/neonatal management. There is an urgent need for further validation of current diagnostic tests and the development of novel, accurate, minimally invasive tests that detect subclinical intra-uterine inflammation. MDPI 2023-10-28 /pmc/articles/PMC10669668/ /pubmed/38001923 http://dx.doi.org/10.3390/biomedicines11112922 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carter, Sean W. D. Neubronner, Samantha Su, Lin Lin Dashraath, Pradip Mattar, Citra Illanes, Sebastián E. Choolani, Mahesh A. Kemp, Matthew W. Chorioamnionitis: An Update on Diagnostic Evaluation |
title | Chorioamnionitis: An Update on Diagnostic Evaluation |
title_full | Chorioamnionitis: An Update on Diagnostic Evaluation |
title_fullStr | Chorioamnionitis: An Update on Diagnostic Evaluation |
title_full_unstemmed | Chorioamnionitis: An Update on Diagnostic Evaluation |
title_short | Chorioamnionitis: An Update on Diagnostic Evaluation |
title_sort | chorioamnionitis: an update on diagnostic evaluation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669668/ https://www.ncbi.nlm.nih.gov/pubmed/38001923 http://dx.doi.org/10.3390/biomedicines11112922 |
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