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Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model

Age-related hearing loss (ARHL) impairs the quality of life in elderly persons. ARHL is associated with comorbidities, such as depression, falls, or frailty. Frailty syndrome is related to poor health outcomes in old age. ARHL is a potentially modifiable risk factor for frailty. Oxidative stress has...

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Autores principales: Fátima Heredia, Rosalía, Riestra-Ayora, Juan I., Yanes-Díaz, Joaquín, Thuissard Vasallo, Israel John, Andreu-Vázquez, Cristina, Sanz-Fernández, Ricardo, Sánchez-Rodríguez, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669688/
https://www.ncbi.nlm.nih.gov/pubmed/38001847
http://dx.doi.org/10.3390/antiox12111994
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author Fátima Heredia, Rosalía
Riestra-Ayora, Juan I.
Yanes-Díaz, Joaquín
Thuissard Vasallo, Israel John
Andreu-Vázquez, Cristina
Sanz-Fernández, Ricardo
Sánchez-Rodríguez, Carolina
author_facet Fátima Heredia, Rosalía
Riestra-Ayora, Juan I.
Yanes-Díaz, Joaquín
Thuissard Vasallo, Israel John
Andreu-Vázquez, Cristina
Sanz-Fernández, Ricardo
Sánchez-Rodríguez, Carolina
author_sort Fátima Heredia, Rosalía
collection PubMed
description Age-related hearing loss (ARHL) impairs the quality of life in elderly persons. ARHL is associated with comorbidities, such as depression, falls, or frailty. Frailty syndrome is related to poor health outcomes in old age. ARHL is a potentially modifiable risk factor for frailty. Oxidative stress has been proposed as a key factor underlying the onset and/or development of ARHL and frailty. Cocoa has high levels of polyphenols and provides many health benefits due to its antioxidant properties. Male and female C57Bl/6J mice were randomly assigned to two study groups: animals receiving a cocoa-supplemented diet and the other receiving a standard diet. Then, at the ages of 6, 14, and 22 months, hearing and frailty were measured in all mice. Auditory steady-state responses (ASSR) threshold shifts were measured to different frequencies. The frailty score was based on the “Valencia Score” adapted to the experimental animals. The total antioxidant capacity and total polyphenols in urine samples were also measured. Significant improvements in hearing ability are observed in the cocoa groups at 6, 14, and 22 months compared to the no cocoa group. The cocoa diet significantly retards the development of frailty in mice. Cocoa increases the concentration of polyphenols excreted in the urine, which increases the total antioxidant capacity. In conclusion, cocoa, due to its antioxidant properties, leads to significant protection against ARHL and frailty.
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spelling pubmed-106696882023-11-12 Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model Fátima Heredia, Rosalía Riestra-Ayora, Juan I. Yanes-Díaz, Joaquín Thuissard Vasallo, Israel John Andreu-Vázquez, Cristina Sanz-Fernández, Ricardo Sánchez-Rodríguez, Carolina Antioxidants (Basel) Article Age-related hearing loss (ARHL) impairs the quality of life in elderly persons. ARHL is associated with comorbidities, such as depression, falls, or frailty. Frailty syndrome is related to poor health outcomes in old age. ARHL is a potentially modifiable risk factor for frailty. Oxidative stress has been proposed as a key factor underlying the onset and/or development of ARHL and frailty. Cocoa has high levels of polyphenols and provides many health benefits due to its antioxidant properties. Male and female C57Bl/6J mice were randomly assigned to two study groups: animals receiving a cocoa-supplemented diet and the other receiving a standard diet. Then, at the ages of 6, 14, and 22 months, hearing and frailty were measured in all mice. Auditory steady-state responses (ASSR) threshold shifts were measured to different frequencies. The frailty score was based on the “Valencia Score” adapted to the experimental animals. The total antioxidant capacity and total polyphenols in urine samples were also measured. Significant improvements in hearing ability are observed in the cocoa groups at 6, 14, and 22 months compared to the no cocoa group. The cocoa diet significantly retards the development of frailty in mice. Cocoa increases the concentration of polyphenols excreted in the urine, which increases the total antioxidant capacity. In conclusion, cocoa, due to its antioxidant properties, leads to significant protection against ARHL and frailty. MDPI 2023-11-12 /pmc/articles/PMC10669688/ /pubmed/38001847 http://dx.doi.org/10.3390/antiox12111994 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fátima Heredia, Rosalía
Riestra-Ayora, Juan I.
Yanes-Díaz, Joaquín
Thuissard Vasallo, Israel John
Andreu-Vázquez, Cristina
Sanz-Fernández, Ricardo
Sánchez-Rodríguez, Carolina
Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title_full Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title_fullStr Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title_full_unstemmed Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title_short Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title_sort cocoa polyphenols prevent age-related hearing loss and frailty in an in vivo model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669688/
https://www.ncbi.nlm.nih.gov/pubmed/38001847
http://dx.doi.org/10.3390/antiox12111994
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