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Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor

Alzheimer’s disease (AD) is closely related to neurodegeneration, leading to dementia and cognitive impairment, especially in people aged > 65 years old. The detection of biomarkers plays a pivotal role in the diagnosis and treatment of AD, particularly at the onset stage. Field-effect transistor...

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Detalles Bibliográficos
Autores principales: Le, Phan Gia, Choi, Seong Hye, Cho, Sungbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669709/
https://www.ncbi.nlm.nih.gov/pubmed/37998162
http://dx.doi.org/10.3390/bios13110987
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author Le, Phan Gia
Choi, Seong Hye
Cho, Sungbo
author_facet Le, Phan Gia
Choi, Seong Hye
Cho, Sungbo
author_sort Le, Phan Gia
collection PubMed
description Alzheimer’s disease (AD) is closely related to neurodegeneration, leading to dementia and cognitive impairment, especially in people aged > 65 years old. The detection of biomarkers plays a pivotal role in the diagnosis and treatment of AD, particularly at the onset stage. Field-effect transistor (FET)-based sensors are emerging devices that have drawn considerable attention due to their crucial ability to recognize various biomarkers at ultra-low concentrations. Thus, FET is broadly manipulated for AD biomarker detection. In this review, an overview of typical FET features and their operational mechanisms is described in detail. In addition, a summary of AD biomarker detection and the applicability of FET biosensors in this research field are outlined and discussed. Furthermore, the trends and future prospects of FET devices in AD diagnostic applications are also discussed.
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spelling pubmed-106697092023-11-17 Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor Le, Phan Gia Choi, Seong Hye Cho, Sungbo Biosensors (Basel) Review Alzheimer’s disease (AD) is closely related to neurodegeneration, leading to dementia and cognitive impairment, especially in people aged > 65 years old. The detection of biomarkers plays a pivotal role in the diagnosis and treatment of AD, particularly at the onset stage. Field-effect transistor (FET)-based sensors are emerging devices that have drawn considerable attention due to their crucial ability to recognize various biomarkers at ultra-low concentrations. Thus, FET is broadly manipulated for AD biomarker detection. In this review, an overview of typical FET features and their operational mechanisms is described in detail. In addition, a summary of AD biomarker detection and the applicability of FET biosensors in this research field are outlined and discussed. Furthermore, the trends and future prospects of FET devices in AD diagnostic applications are also discussed. MDPI 2023-11-17 /pmc/articles/PMC10669709/ /pubmed/37998162 http://dx.doi.org/10.3390/bios13110987 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Le, Phan Gia
Choi, Seong Hye
Cho, Sungbo
Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor
title Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor
title_full Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor
title_fullStr Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor
title_full_unstemmed Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor
title_short Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor
title_sort alzheimer’s disease biomarker detection using field effect transistor-based biosensor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669709/
https://www.ncbi.nlm.nih.gov/pubmed/37998162
http://dx.doi.org/10.3390/bios13110987
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