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Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor
Alzheimer’s disease (AD) is closely related to neurodegeneration, leading to dementia and cognitive impairment, especially in people aged > 65 years old. The detection of biomarkers plays a pivotal role in the diagnosis and treatment of AD, particularly at the onset stage. Field-effect transistor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669709/ https://www.ncbi.nlm.nih.gov/pubmed/37998162 http://dx.doi.org/10.3390/bios13110987 |
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author | Le, Phan Gia Choi, Seong Hye Cho, Sungbo |
author_facet | Le, Phan Gia Choi, Seong Hye Cho, Sungbo |
author_sort | Le, Phan Gia |
collection | PubMed |
description | Alzheimer’s disease (AD) is closely related to neurodegeneration, leading to dementia and cognitive impairment, especially in people aged > 65 years old. The detection of biomarkers plays a pivotal role in the diagnosis and treatment of AD, particularly at the onset stage. Field-effect transistor (FET)-based sensors are emerging devices that have drawn considerable attention due to their crucial ability to recognize various biomarkers at ultra-low concentrations. Thus, FET is broadly manipulated for AD biomarker detection. In this review, an overview of typical FET features and their operational mechanisms is described in detail. In addition, a summary of AD biomarker detection and the applicability of FET biosensors in this research field are outlined and discussed. Furthermore, the trends and future prospects of FET devices in AD diagnostic applications are also discussed. |
format | Online Article Text |
id | pubmed-10669709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106697092023-11-17 Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor Le, Phan Gia Choi, Seong Hye Cho, Sungbo Biosensors (Basel) Review Alzheimer’s disease (AD) is closely related to neurodegeneration, leading to dementia and cognitive impairment, especially in people aged > 65 years old. The detection of biomarkers plays a pivotal role in the diagnosis and treatment of AD, particularly at the onset stage. Field-effect transistor (FET)-based sensors are emerging devices that have drawn considerable attention due to their crucial ability to recognize various biomarkers at ultra-low concentrations. Thus, FET is broadly manipulated for AD biomarker detection. In this review, an overview of typical FET features and their operational mechanisms is described in detail. In addition, a summary of AD biomarker detection and the applicability of FET biosensors in this research field are outlined and discussed. Furthermore, the trends and future prospects of FET devices in AD diagnostic applications are also discussed. MDPI 2023-11-17 /pmc/articles/PMC10669709/ /pubmed/37998162 http://dx.doi.org/10.3390/bios13110987 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Le, Phan Gia Choi, Seong Hye Cho, Sungbo Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor |
title | Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor |
title_full | Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor |
title_fullStr | Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor |
title_full_unstemmed | Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor |
title_short | Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor |
title_sort | alzheimer’s disease biomarker detection using field effect transistor-based biosensor |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669709/ https://www.ncbi.nlm.nih.gov/pubmed/37998162 http://dx.doi.org/10.3390/bios13110987 |
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