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The Presence of Communicating Arteries in the Circle of Willis Is Associated with Higher Rate of Functional Recovery after Anterior Circulation Ischemic Stroke

Acute ischemic stroke (AIS) is the world’s second leading cause of mortality. An established method for treating stroke patients in acute settings is endovascular therapy (EVT). However, the correlation of the successful endovascular treatment of AIS with the presence of communicating arteries in th...

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Autores principales: Sablić, Sara, Dolić, Krešimir, Kraljević, Ivan, Budimir Mršić, Danijela, Čičmir-Vestić, Mate, Benzon, Benjamin, Lovrić Kojundžić, Sanja, Marinović Guić, Maja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669712/
https://www.ncbi.nlm.nih.gov/pubmed/38002008
http://dx.doi.org/10.3390/biomedicines11113008
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author Sablić, Sara
Dolić, Krešimir
Kraljević, Ivan
Budimir Mršić, Danijela
Čičmir-Vestić, Mate
Benzon, Benjamin
Lovrić Kojundžić, Sanja
Marinović Guić, Maja
author_facet Sablić, Sara
Dolić, Krešimir
Kraljević, Ivan
Budimir Mršić, Danijela
Čičmir-Vestić, Mate
Benzon, Benjamin
Lovrić Kojundžić, Sanja
Marinović Guić, Maja
author_sort Sablić, Sara
collection PubMed
description Acute ischemic stroke (AIS) is the world’s second leading cause of mortality. An established method for treating stroke patients in acute settings is endovascular therapy (EVT). However, the correlation of the successful endovascular treatment of AIS with the presence of communicating arteries in the circle of Willis needs to be proven. Our study examined clinical and radiological data of 158 consecutive patients treated with mechanical thrombectomy (MT) at our comprehensive stroke center. We analyzed their CT angiograms and digital subtraction angiography (DSA) to assess anatomical variants of Willis’ circle and formed two groups—collateral-negative and collateral-positive group. The first group included patients with aplasia of both anterior (ACoA) and posterior communicating Artery (PCoA). The second group included patients that have at least one communicating artery (either anterior or posterior). We evaluated their reperfusion outcomes and functional recovery three months later. Our results showed that patients with communicating arteries had smaller areas of infarction on post-interventional CT and higher rates of functional recovery (Modified Rankin Score). The ACoA had a higher impact on early and late outcomes, confirmed by lower control CT scores and more favorable functional recovery. Therefore, anatomic variants of Willis’ circle should be considered as a significant prognostic factor in AIS.
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spelling pubmed-106697122023-11-09 The Presence of Communicating Arteries in the Circle of Willis Is Associated with Higher Rate of Functional Recovery after Anterior Circulation Ischemic Stroke Sablić, Sara Dolić, Krešimir Kraljević, Ivan Budimir Mršić, Danijela Čičmir-Vestić, Mate Benzon, Benjamin Lovrić Kojundžić, Sanja Marinović Guić, Maja Biomedicines Article Acute ischemic stroke (AIS) is the world’s second leading cause of mortality. An established method for treating stroke patients in acute settings is endovascular therapy (EVT). However, the correlation of the successful endovascular treatment of AIS with the presence of communicating arteries in the circle of Willis needs to be proven. Our study examined clinical and radiological data of 158 consecutive patients treated with mechanical thrombectomy (MT) at our comprehensive stroke center. We analyzed their CT angiograms and digital subtraction angiography (DSA) to assess anatomical variants of Willis’ circle and formed two groups—collateral-negative and collateral-positive group. The first group included patients with aplasia of both anterior (ACoA) and posterior communicating Artery (PCoA). The second group included patients that have at least one communicating artery (either anterior or posterior). We evaluated their reperfusion outcomes and functional recovery three months later. Our results showed that patients with communicating arteries had smaller areas of infarction on post-interventional CT and higher rates of functional recovery (Modified Rankin Score). The ACoA had a higher impact on early and late outcomes, confirmed by lower control CT scores and more favorable functional recovery. Therefore, anatomic variants of Willis’ circle should be considered as a significant prognostic factor in AIS. MDPI 2023-11-09 /pmc/articles/PMC10669712/ /pubmed/38002008 http://dx.doi.org/10.3390/biomedicines11113008 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sablić, Sara
Dolić, Krešimir
Kraljević, Ivan
Budimir Mršić, Danijela
Čičmir-Vestić, Mate
Benzon, Benjamin
Lovrić Kojundžić, Sanja
Marinović Guić, Maja
The Presence of Communicating Arteries in the Circle of Willis Is Associated with Higher Rate of Functional Recovery after Anterior Circulation Ischemic Stroke
title The Presence of Communicating Arteries in the Circle of Willis Is Associated with Higher Rate of Functional Recovery after Anterior Circulation Ischemic Stroke
title_full The Presence of Communicating Arteries in the Circle of Willis Is Associated with Higher Rate of Functional Recovery after Anterior Circulation Ischemic Stroke
title_fullStr The Presence of Communicating Arteries in the Circle of Willis Is Associated with Higher Rate of Functional Recovery after Anterior Circulation Ischemic Stroke
title_full_unstemmed The Presence of Communicating Arteries in the Circle of Willis Is Associated with Higher Rate of Functional Recovery after Anterior Circulation Ischemic Stroke
title_short The Presence of Communicating Arteries in the Circle of Willis Is Associated with Higher Rate of Functional Recovery after Anterior Circulation Ischemic Stroke
title_sort presence of communicating arteries in the circle of willis is associated with higher rate of functional recovery after anterior circulation ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669712/
https://www.ncbi.nlm.nih.gov/pubmed/38002008
http://dx.doi.org/10.3390/biomedicines11113008
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