Biological Effects of HDAC Inhibitors Vary with Zinc Binding Group: Differential Effects on Zinc Bioavailability, ROS Production, and R175H p53 Mutant Protein Reactivation

The coordination of zinc by histone deacetylase inhibitors (HDACi), altering the bioavailability of zinc to histone deacetylases (HDACs), is key to HDAC enzyme inhibition. However, the ability of zinc binding groups (ZBGs) to alter intracellular free Zn(+2) levels, which may have far-reaching effect...

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Detalles Bibliográficos
Autores principales: Flores, Brianna M., Uppalapati, Chandana K., Pascual, Agnes S., Vong, Alan, Baatz, Margaux A., Harrison, Alisha M., Leyva, Kathryn J., Hull, Elizabeth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669723/
https://www.ncbi.nlm.nih.gov/pubmed/38002270
http://dx.doi.org/10.3390/biom13111588

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