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The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression

The high mortality from lung cancer is mainly attributed to the presence of metastases at the time of diagnosis. Despite being the leading cause of lung cancer death, the underlying molecular mechanisms driving metastasis progression are still not fully understood. Recent studies suggest that tumor...

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Autores principales: Martinez-Espinosa, Israel, Serrato, José Antonio, Ortiz-Quintero, Blanca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669807/
https://www.ncbi.nlm.nih.gov/pubmed/38002256
http://dx.doi.org/10.3390/biom13111574
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author Martinez-Espinosa, Israel
Serrato, José Antonio
Ortiz-Quintero, Blanca
author_facet Martinez-Espinosa, Israel
Serrato, José Antonio
Ortiz-Quintero, Blanca
author_sort Martinez-Espinosa, Israel
collection PubMed
description The high mortality from lung cancer is mainly attributed to the presence of metastases at the time of diagnosis. Despite being the leading cause of lung cancer death, the underlying molecular mechanisms driving metastasis progression are still not fully understood. Recent studies suggest that tumor cell exosomes play a significant role in tumor progression through intercellular communication between tumor cells, the microenvironment, and distant organs. Furthermore, evidence shows that exosomes release biologically active components to distant sites and organs, which direct metastasis by preparing metastatic pre-niche and stimulating tumorigenesis. As a result, identifying the active components of exosome cargo has become a critical area of research in recent years. Among these components are microRNAs, which are associated with tumor progression and metastasis in lung cancer. Although research into exosome-derived microRNA (exosomal miRNAs) is still in its early stages, it holds promise as a potential target for lung cancer therapy. Understanding how exosomal microRNAs promote metastasis will provide evidence for developing new targeted treatments. This review summarizes current research on exosomal miRNAs’ role in metastasis progression mechanisms, focusing on lung cancer.
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spelling pubmed-106698072023-10-25 The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression Martinez-Espinosa, Israel Serrato, José Antonio Ortiz-Quintero, Blanca Biomolecules Review The high mortality from lung cancer is mainly attributed to the presence of metastases at the time of diagnosis. Despite being the leading cause of lung cancer death, the underlying molecular mechanisms driving metastasis progression are still not fully understood. Recent studies suggest that tumor cell exosomes play a significant role in tumor progression through intercellular communication between tumor cells, the microenvironment, and distant organs. Furthermore, evidence shows that exosomes release biologically active components to distant sites and organs, which direct metastasis by preparing metastatic pre-niche and stimulating tumorigenesis. As a result, identifying the active components of exosome cargo has become a critical area of research in recent years. Among these components are microRNAs, which are associated with tumor progression and metastasis in lung cancer. Although research into exosome-derived microRNA (exosomal miRNAs) is still in its early stages, it holds promise as a potential target for lung cancer therapy. Understanding how exosomal microRNAs promote metastasis will provide evidence for developing new targeted treatments. This review summarizes current research on exosomal miRNAs’ role in metastasis progression mechanisms, focusing on lung cancer. MDPI 2023-10-25 /pmc/articles/PMC10669807/ /pubmed/38002256 http://dx.doi.org/10.3390/biom13111574 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martinez-Espinosa, Israel
Serrato, José Antonio
Ortiz-Quintero, Blanca
The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression
title The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression
title_full The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression
title_fullStr The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression
title_full_unstemmed The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression
title_short The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression
title_sort role of exosome-derived microrna on lung cancer metastasis progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669807/
https://www.ncbi.nlm.nih.gov/pubmed/38002256
http://dx.doi.org/10.3390/biom13111574
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