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Advancements in Composite Materials and Their Expanding Role in Biomedical Applications

The synthesis of a Ni-doped ZnO nanocomposite incorporating chitosan (CS/Ni-doped ZnO) was achieved via a precipitation method, followed by annealing at 250 °C. This study comprehensively examined the nanocomposite’s structural, functional, morphological, and porosity properties using various analyt...

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Detalles Bibliográficos
Autores principales: Jeyachandran, Sivakamavalli, Chellapandian, Hethesh, Ali, Nemat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669831/
https://www.ncbi.nlm.nih.gov/pubmed/37999159
http://dx.doi.org/10.3390/biomimetics8070518
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author Jeyachandran, Sivakamavalli
Chellapandian, Hethesh
Ali, Nemat
author_facet Jeyachandran, Sivakamavalli
Chellapandian, Hethesh
Ali, Nemat
author_sort Jeyachandran, Sivakamavalli
collection PubMed
description The synthesis of a Ni-doped ZnO nanocomposite incorporating chitosan (CS/Ni-doped ZnO) was achieved via a precipitation method, followed by annealing at 250 °C. This study comprehensively examined the nanocomposite’s structural, functional, morphological, and porosity properties using various analytical techniques, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), high-resolution scanning electron microscopy (HR-SEM), transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET) analysis. The presence of chitosan (CS) and nickel (Ni) within the nanocomposite, along with their influence on reducing the band gap of ZnO particles and enhancing the generation of electron-hole pairs, was confirmed using UV-visible near-infrared spectroscopy (UV-vis-NIR). The electrochemical properties of the CS/Ni-doped ZnO nanocomposite were investigated via electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) by utilizing a phosphate buffer solution with a pH of 6, which closely resembled the typical pH of bacterial cell walls. Finally, the prepared CS/Ni-doped ZnO nanocomposite was evaluated for its antibacterial and anticancer activities. The results demonstrated the highest inhibition of bacterial growth in P. vulgaris, whereas the lowest inhibition was found in S. aureus across various concentrations, thus highlighting its potential in antimicrobial applications. The cytotoxicity of CS/Ni-doped ZnO nanocomposites demonstrated remarkable effects with a half-maximum inhibitory concentration of approximately 80 ± 0.23 µg mL(−1) against MCF-7 breast cancer cell lines, following a dose-dependent manner.
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spelling pubmed-106698312023-11-01 Advancements in Composite Materials and Their Expanding Role in Biomedical Applications Jeyachandran, Sivakamavalli Chellapandian, Hethesh Ali, Nemat Biomimetics (Basel) Article The synthesis of a Ni-doped ZnO nanocomposite incorporating chitosan (CS/Ni-doped ZnO) was achieved via a precipitation method, followed by annealing at 250 °C. This study comprehensively examined the nanocomposite’s structural, functional, morphological, and porosity properties using various analytical techniques, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), high-resolution scanning electron microscopy (HR-SEM), transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET) analysis. The presence of chitosan (CS) and nickel (Ni) within the nanocomposite, along with their influence on reducing the band gap of ZnO particles and enhancing the generation of electron-hole pairs, was confirmed using UV-visible near-infrared spectroscopy (UV-vis-NIR). The electrochemical properties of the CS/Ni-doped ZnO nanocomposite were investigated via electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) by utilizing a phosphate buffer solution with a pH of 6, which closely resembled the typical pH of bacterial cell walls. Finally, the prepared CS/Ni-doped ZnO nanocomposite was evaluated for its antibacterial and anticancer activities. The results demonstrated the highest inhibition of bacterial growth in P. vulgaris, whereas the lowest inhibition was found in S. aureus across various concentrations, thus highlighting its potential in antimicrobial applications. The cytotoxicity of CS/Ni-doped ZnO nanocomposites demonstrated remarkable effects with a half-maximum inhibitory concentration of approximately 80 ± 0.23 µg mL(−1) against MCF-7 breast cancer cell lines, following a dose-dependent manner. MDPI 2023-11-01 /pmc/articles/PMC10669831/ /pubmed/37999159 http://dx.doi.org/10.3390/biomimetics8070518 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jeyachandran, Sivakamavalli
Chellapandian, Hethesh
Ali, Nemat
Advancements in Composite Materials and Their Expanding Role in Biomedical Applications
title Advancements in Composite Materials and Their Expanding Role in Biomedical Applications
title_full Advancements in Composite Materials and Their Expanding Role in Biomedical Applications
title_fullStr Advancements in Composite Materials and Their Expanding Role in Biomedical Applications
title_full_unstemmed Advancements in Composite Materials and Their Expanding Role in Biomedical Applications
title_short Advancements in Composite Materials and Their Expanding Role in Biomedical Applications
title_sort advancements in composite materials and their expanding role in biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669831/
https://www.ncbi.nlm.nih.gov/pubmed/37999159
http://dx.doi.org/10.3390/biomimetics8070518
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