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Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions
This study aims to examine the feasibility of DNA methylation age as a biomarker for symptoms and resilience in cancer survivors with multiple chronic conditions (MCCs). We included ten participants from our parent study, an ongoing randomized control trial study. Participants’ symptoms and resilien...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669866/ https://www.ncbi.nlm.nih.gov/pubmed/38002076 http://dx.doi.org/10.3390/biomedicines11113076 |
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author | Lukkahatai, Nada Park, Jongmin Jia, Hejingzi Monica Martin, Daniel Li, Junxin Sheng, Jennifer Yeong-Shin Gill, Jessica Saligan, Leorey N. Stearns, Vered Carducci, Michael |
author_facet | Lukkahatai, Nada Park, Jongmin Jia, Hejingzi Monica Martin, Daniel Li, Junxin Sheng, Jennifer Yeong-Shin Gill, Jessica Saligan, Leorey N. Stearns, Vered Carducci, Michael |
author_sort | Lukkahatai, Nada |
collection | PubMed |
description | This study aims to examine the feasibility of DNA methylation age as a biomarker for symptoms and resilience in cancer survivors with multiple chronic conditions (MCCs). We included ten participants from our parent study, an ongoing randomized control trial study. Participants’ symptoms and resilience were assessed, and peripheral blood was collected. DNA methylation age calculation was performed using DNAge(®) analysis. Data were analyzed using Spearman’s correlation analysis and the Mann–Whitney U test. Participants in the intervention group tended to have a decrease in DNA methylation age and age acceleration after completing an exercise program (mean difference = −0.83 ± 1.26). The change in DNA methylation age was significantly correlated with the change in resilience score (r = −0.897, p = 0.015). The preliminary results suggest that DNA methylation age can be a potential biomarker for improving resilience in cancer survivors with multiple chronic conditions. This finding is limited by the small sample size, and a larger study is needed. |
format | Online Article Text |
id | pubmed-10669866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106698662023-11-16 Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions Lukkahatai, Nada Park, Jongmin Jia, Hejingzi Monica Martin, Daniel Li, Junxin Sheng, Jennifer Yeong-Shin Gill, Jessica Saligan, Leorey N. Stearns, Vered Carducci, Michael Biomedicines Article This study aims to examine the feasibility of DNA methylation age as a biomarker for symptoms and resilience in cancer survivors with multiple chronic conditions (MCCs). We included ten participants from our parent study, an ongoing randomized control trial study. Participants’ symptoms and resilience were assessed, and peripheral blood was collected. DNA methylation age calculation was performed using DNAge(®) analysis. Data were analyzed using Spearman’s correlation analysis and the Mann–Whitney U test. Participants in the intervention group tended to have a decrease in DNA methylation age and age acceleration after completing an exercise program (mean difference = −0.83 ± 1.26). The change in DNA methylation age was significantly correlated with the change in resilience score (r = −0.897, p = 0.015). The preliminary results suggest that DNA methylation age can be a potential biomarker for improving resilience in cancer survivors with multiple chronic conditions. This finding is limited by the small sample size, and a larger study is needed. MDPI 2023-11-16 /pmc/articles/PMC10669866/ /pubmed/38002076 http://dx.doi.org/10.3390/biomedicines11113076 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lukkahatai, Nada Park, Jongmin Jia, Hejingzi Monica Martin, Daniel Li, Junxin Sheng, Jennifer Yeong-Shin Gill, Jessica Saligan, Leorey N. Stearns, Vered Carducci, Michael Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
title | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
title_full | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
title_fullStr | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
title_full_unstemmed | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
title_short | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
title_sort | feasibility of dna methylation age as a biomarker of symptoms and resilience among cancer survivors with multiple chronic conditions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669866/ https://www.ncbi.nlm.nih.gov/pubmed/38002076 http://dx.doi.org/10.3390/biomedicines11113076 |
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