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Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of endothelial and epithelial barriers, and the activation of inflammatory cascades. Despite the increasing number of deaths att...

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Detalles Bibliográficos
Autores principales: Lim, Eun Yeong, Lee, So-Young, Shin, Hee Soon, Kim, Gun-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669909/
https://www.ncbi.nlm.nih.gov/pubmed/38001869
http://dx.doi.org/10.3390/antiox12112016
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author Lim, Eun Yeong
Lee, So-Young
Shin, Hee Soon
Kim, Gun-Dong
author_facet Lim, Eun Yeong
Lee, So-Young
Shin, Hee Soon
Kim, Gun-Dong
author_sort Lim, Eun Yeong
collection PubMed
description Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of endothelial and epithelial barriers, and the activation of inflammatory cascades. Despite the increasing number of deaths attributed to ARDS, a comprehensive therapeutic approach for managing patients with ARDS remains elusive. To elucidate the pathological mechanisms underlying ARDS, numerous studies have employed various preclinical models, often utilizing lipopolysaccharide as the ARDS inducer. Accumulating evidence emphasizes the pivotal role of reactive oxygen species (ROS) in the pathophysiology of ARDS. Both preclinical and clinical investigations have asserted the potential of antioxidants in ameliorating ARDS. This review focuses on various sources of ROS, including NADPH oxidase, uncoupled endothelial nitric oxide synthase, cytochrome P450, and xanthine oxidase, and provides a comprehensive overview of their roles in ARDS. Additionally, we discuss the potential of using antioxidants as a strategy for treating ARDS.
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spelling pubmed-106699092023-11-18 Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome Lim, Eun Yeong Lee, So-Young Shin, Hee Soon Kim, Gun-Dong Antioxidants (Basel) Review Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of endothelial and epithelial barriers, and the activation of inflammatory cascades. Despite the increasing number of deaths attributed to ARDS, a comprehensive therapeutic approach for managing patients with ARDS remains elusive. To elucidate the pathological mechanisms underlying ARDS, numerous studies have employed various preclinical models, often utilizing lipopolysaccharide as the ARDS inducer. Accumulating evidence emphasizes the pivotal role of reactive oxygen species (ROS) in the pathophysiology of ARDS. Both preclinical and clinical investigations have asserted the potential of antioxidants in ameliorating ARDS. This review focuses on various sources of ROS, including NADPH oxidase, uncoupled endothelial nitric oxide synthase, cytochrome P450, and xanthine oxidase, and provides a comprehensive overview of their roles in ARDS. Additionally, we discuss the potential of using antioxidants as a strategy for treating ARDS. MDPI 2023-11-18 /pmc/articles/PMC10669909/ /pubmed/38001869 http://dx.doi.org/10.3390/antiox12112016 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lim, Eun Yeong
Lee, So-Young
Shin, Hee Soon
Kim, Gun-Dong
Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome
title Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome
title_full Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome
title_fullStr Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome
title_full_unstemmed Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome
title_short Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome
title_sort reactive oxygen species and strategies for antioxidant intervention in acute respiratory distress syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669909/
https://www.ncbi.nlm.nih.gov/pubmed/38001869
http://dx.doi.org/10.3390/antiox12112016
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