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Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of endothelial and epithelial barriers, and the activation of inflammatory cascades. Despite the increasing number of deaths att...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669909/ https://www.ncbi.nlm.nih.gov/pubmed/38001869 http://dx.doi.org/10.3390/antiox12112016 |
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author | Lim, Eun Yeong Lee, So-Young Shin, Hee Soon Kim, Gun-Dong |
author_facet | Lim, Eun Yeong Lee, So-Young Shin, Hee Soon Kim, Gun-Dong |
author_sort | Lim, Eun Yeong |
collection | PubMed |
description | Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of endothelial and epithelial barriers, and the activation of inflammatory cascades. Despite the increasing number of deaths attributed to ARDS, a comprehensive therapeutic approach for managing patients with ARDS remains elusive. To elucidate the pathological mechanisms underlying ARDS, numerous studies have employed various preclinical models, often utilizing lipopolysaccharide as the ARDS inducer. Accumulating evidence emphasizes the pivotal role of reactive oxygen species (ROS) in the pathophysiology of ARDS. Both preclinical and clinical investigations have asserted the potential of antioxidants in ameliorating ARDS. This review focuses on various sources of ROS, including NADPH oxidase, uncoupled endothelial nitric oxide synthase, cytochrome P450, and xanthine oxidase, and provides a comprehensive overview of their roles in ARDS. Additionally, we discuss the potential of using antioxidants as a strategy for treating ARDS. |
format | Online Article Text |
id | pubmed-10669909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106699092023-11-18 Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome Lim, Eun Yeong Lee, So-Young Shin, Hee Soon Kim, Gun-Dong Antioxidants (Basel) Review Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of endothelial and epithelial barriers, and the activation of inflammatory cascades. Despite the increasing number of deaths attributed to ARDS, a comprehensive therapeutic approach for managing patients with ARDS remains elusive. To elucidate the pathological mechanisms underlying ARDS, numerous studies have employed various preclinical models, often utilizing lipopolysaccharide as the ARDS inducer. Accumulating evidence emphasizes the pivotal role of reactive oxygen species (ROS) in the pathophysiology of ARDS. Both preclinical and clinical investigations have asserted the potential of antioxidants in ameliorating ARDS. This review focuses on various sources of ROS, including NADPH oxidase, uncoupled endothelial nitric oxide synthase, cytochrome P450, and xanthine oxidase, and provides a comprehensive overview of their roles in ARDS. Additionally, we discuss the potential of using antioxidants as a strategy for treating ARDS. MDPI 2023-11-18 /pmc/articles/PMC10669909/ /pubmed/38001869 http://dx.doi.org/10.3390/antiox12112016 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lim, Eun Yeong Lee, So-Young Shin, Hee Soon Kim, Gun-Dong Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome |
title | Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome |
title_full | Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome |
title_fullStr | Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome |
title_full_unstemmed | Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome |
title_short | Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome |
title_sort | reactive oxygen species and strategies for antioxidant intervention in acute respiratory distress syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669909/ https://www.ncbi.nlm.nih.gov/pubmed/38001869 http://dx.doi.org/10.3390/antiox12112016 |
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