SIRT1 Prevents R-Loops during Chronological Aging by Modulating DNA Replication at rDNA Loci

In metazoans, the largest sirtuin, SIRT1, is a nuclear protein implicated in epigenetic modifications, circadian signaling, DNA recombination, replication, and repair. Our previous studies have demonstrated that SIRT1 binds replication origins and inhibits replication initiation from a group of pote...

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Detalles Bibliográficos
Autores principales: Thakur, Bhushan L., Kusi, Nana A., Mosavarpour, Sara, Zhu, Roger, Redon, Christophe E., Fu, Haiqing, Dhall, Anjali, Pongor, Lorinc S., Sebastian, Robin, Indig, Fred E., Aladjem, Mirit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669956/
https://www.ncbi.nlm.nih.gov/pubmed/37998365
http://dx.doi.org/10.3390/cells12222630

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