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Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting

Magnetic resonance imaging (MRI) is a non-invasive imaging technique that is commonly used for the visualization of newborn infant brains, both for clinical and research purposes. One of the main challenges with scanning newborn infants, particularly when scanning without sedation in a research sett...

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Autores principales: King, Regan, Low, Selma, Gee, Nancy, Wood, Roger, Hadweh, Bonny, Houghton, Joanne, Leijser, Lara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669995/
https://www.ncbi.nlm.nih.gov/pubmed/38002850
http://dx.doi.org/10.3390/children10111759
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author King, Regan
Low, Selma
Gee, Nancy
Wood, Roger
Hadweh, Bonny
Houghton, Joanne
Leijser, Lara M.
author_facet King, Regan
Low, Selma
Gee, Nancy
Wood, Roger
Hadweh, Bonny
Houghton, Joanne
Leijser, Lara M.
author_sort King, Regan
collection PubMed
description Magnetic resonance imaging (MRI) is a non-invasive imaging technique that is commonly used for the visualization of newborn infant brains, both for clinical and research purposes. One of the main challenges with scanning newborn infants, particularly when scanning without sedation in a research setting, is movement. Infant movement can affect MR image quality and therewith reliable image assessment and advanced image analysis. Applying a systematic, stepwise approach to MR scanning during the neonatal period, including the use of the feed-and-bundle technique, is effective in reducing infant motion and ensuring high-quality images. We provide recommendations for one such systematic approach, including the step-by-step preparation and infant immobilization, and highlight safety precautions to minimize any potential risks. The recommendations are primarily focused on scanning newborn infants for research purposes but may be used successfully for clinical purposes as well, granted the infant is medically stable. Using the stepwise approach in our local research setting, our success rate of acquiring high-quality, analyzable infant brain MR images during the neonatal period is as high as 91%.
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spelling pubmed-106699952023-10-30 Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting King, Regan Low, Selma Gee, Nancy Wood, Roger Hadweh, Bonny Houghton, Joanne Leijser, Lara M. Children (Basel) Article Magnetic resonance imaging (MRI) is a non-invasive imaging technique that is commonly used for the visualization of newborn infant brains, both for clinical and research purposes. One of the main challenges with scanning newborn infants, particularly when scanning without sedation in a research setting, is movement. Infant movement can affect MR image quality and therewith reliable image assessment and advanced image analysis. Applying a systematic, stepwise approach to MR scanning during the neonatal period, including the use of the feed-and-bundle technique, is effective in reducing infant motion and ensuring high-quality images. We provide recommendations for one such systematic approach, including the step-by-step preparation and infant immobilization, and highlight safety precautions to minimize any potential risks. The recommendations are primarily focused on scanning newborn infants for research purposes but may be used successfully for clinical purposes as well, granted the infant is medically stable. Using the stepwise approach in our local research setting, our success rate of acquiring high-quality, analyzable infant brain MR images during the neonatal period is as high as 91%. MDPI 2023-10-30 /pmc/articles/PMC10669995/ /pubmed/38002850 http://dx.doi.org/10.3390/children10111759 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
King, Regan
Low, Selma
Gee, Nancy
Wood, Roger
Hadweh, Bonny
Houghton, Joanne
Leijser, Lara M.
Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting
title Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting
title_full Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting
title_fullStr Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting
title_full_unstemmed Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting
title_short Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting
title_sort practical stepwise approach to performing neonatal brain mr imaging in the research setting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669995/
https://www.ncbi.nlm.nih.gov/pubmed/38002850
http://dx.doi.org/10.3390/children10111759
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