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Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study
Bronchopulmonary dysplasia (BPD) is a major respiratory condition mainly affecting premature infants. Although its occurrence is global, risk factors may differ regionally. This study, involving 3111 infants with birth weight ≤ 1500 gm or gestational age (GA) < 30 weeks, aimed to identify risk fa...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670039/ https://www.ncbi.nlm.nih.gov/pubmed/38002913 http://dx.doi.org/10.3390/children10111822 |
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author | Huang, Lin-Yi Lin, Ting-I Lin, Chyi-Her Yang, San-Nan Chen, Wan-Ju Wu, Chien-Yi Liu, Hsien-Kuan Wu, Pei-Ling Suen, Jau-Ling Chen, Jung-Sheng Yang, Yung-Ning |
author_facet | Huang, Lin-Yi Lin, Ting-I Lin, Chyi-Her Yang, San-Nan Chen, Wan-Ju Wu, Chien-Yi Liu, Hsien-Kuan Wu, Pei-Ling Suen, Jau-Ling Chen, Jung-Sheng Yang, Yung-Ning |
author_sort | Huang, Lin-Yi |
collection | PubMed |
description | Bronchopulmonary dysplasia (BPD) is a major respiratory condition mainly affecting premature infants. Although its occurrence is global, risk factors may differ regionally. This study, involving 3111 infants with birth weight ≤ 1500 gm or gestational age (GA) < 30 weeks, aimed to identify risk factors for BPD and BPD/mortality in Taiwan using data from the Taiwan Neonatal Network. The BPD criteria were based on the National Institute of Child Health and Human Development standards. Average GA was 27.5 weeks, with 23.7% classified as small for GA (SGA). Multivariate analysis highlighted low GA, low birth weight, and other perinatal factors as significant risk indicators for BPD. For moderate-to-severe BPD, additional risk factors included male gender and SGA, endotracheal intubation (ETT) or cardiopulmonary cerebral resuscitation (CPCR) in initial resuscitation. In the moderate-to-severe BPD/death group, SGA and ETT or CPCR in initial resuscitation remained the only additional risk factors. The study pinpoints male gender, SGA and ETT or CPCR as key risk factors for moderate-to-severe BPD/death in low-birth-weight infants in Taiwan, offering a basis for focused interventions and further research. |
format | Online Article Text |
id | pubmed-10670039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106700392023-11-17 Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study Huang, Lin-Yi Lin, Ting-I Lin, Chyi-Her Yang, San-Nan Chen, Wan-Ju Wu, Chien-Yi Liu, Hsien-Kuan Wu, Pei-Ling Suen, Jau-Ling Chen, Jung-Sheng Yang, Yung-Ning Children (Basel) Article Bronchopulmonary dysplasia (BPD) is a major respiratory condition mainly affecting premature infants. Although its occurrence is global, risk factors may differ regionally. This study, involving 3111 infants with birth weight ≤ 1500 gm or gestational age (GA) < 30 weeks, aimed to identify risk factors for BPD and BPD/mortality in Taiwan using data from the Taiwan Neonatal Network. The BPD criteria were based on the National Institute of Child Health and Human Development standards. Average GA was 27.5 weeks, with 23.7% classified as small for GA (SGA). Multivariate analysis highlighted low GA, low birth weight, and other perinatal factors as significant risk indicators for BPD. For moderate-to-severe BPD, additional risk factors included male gender and SGA, endotracheal intubation (ETT) or cardiopulmonary cerebral resuscitation (CPCR) in initial resuscitation. In the moderate-to-severe BPD/death group, SGA and ETT or CPCR in initial resuscitation remained the only additional risk factors. The study pinpoints male gender, SGA and ETT or CPCR as key risk factors for moderate-to-severe BPD/death in low-birth-weight infants in Taiwan, offering a basis for focused interventions and further research. MDPI 2023-11-17 /pmc/articles/PMC10670039/ /pubmed/38002913 http://dx.doi.org/10.3390/children10111822 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Lin-Yi Lin, Ting-I Lin, Chyi-Her Yang, San-Nan Chen, Wan-Ju Wu, Chien-Yi Liu, Hsien-Kuan Wu, Pei-Ling Suen, Jau-Ling Chen, Jung-Sheng Yang, Yung-Ning Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study |
title | Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study |
title_full | Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study |
title_fullStr | Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study |
title_full_unstemmed | Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study |
title_short | Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study |
title_sort | comprehensive analysis of risk factors for bronchopulmonary dysplasia in preterm infants in taiwan: a four-year study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670039/ https://www.ncbi.nlm.nih.gov/pubmed/38002913 http://dx.doi.org/10.3390/children10111822 |
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