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Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner

Background: PET imaging after yttrium-90 (Y-90) radioembolization is challenging because of the low positron fraction of Y-90 (32 × 10(−6)). The resulting low number of events can be compensated by the high sensitivity of long axial field-of-view (LAFOV) PET/CT scanners. Nevertheless, the reduced ev...

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Autores principales: Linder, Pia M., Lan, Wenhong, Trautwein, Nils F., Brosch-Lenz, Julia, von Beschwitz, Sebastian, Kupferschläger, Jürgen, Reischl, Gerald, Grözinger, Gerd, Dittmann, Helmut, la Fougère, Christian, Schmidt, Fabian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670048/
https://www.ncbi.nlm.nih.gov/pubmed/37998554
http://dx.doi.org/10.3390/diagnostics13223418
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author Linder, Pia M.
Lan, Wenhong
Trautwein, Nils F.
Brosch-Lenz, Julia
von Beschwitz, Sebastian
Kupferschläger, Jürgen
Reischl, Gerald
Grözinger, Gerd
Dittmann, Helmut
la Fougère, Christian
Schmidt, Fabian P.
author_facet Linder, Pia M.
Lan, Wenhong
Trautwein, Nils F.
Brosch-Lenz, Julia
von Beschwitz, Sebastian
Kupferschläger, Jürgen
Reischl, Gerald
Grözinger, Gerd
Dittmann, Helmut
la Fougère, Christian
Schmidt, Fabian P.
author_sort Linder, Pia M.
collection PubMed
description Background: PET imaging after yttrium-90 (Y-90) radioembolization is challenging because of the low positron fraction of Y-90 (32 × 10(−6)). The resulting low number of events can be compensated by the high sensitivity of long axial field-of-view (LAFOV) PET/CT scanners. Nevertheless, the reduced event statistics require optimization of the imaging protocol to achieve high image quality (IQ) and quantification accuracy sufficient for post-treatment dosimetry. Methods: Two phantoms (NEMA IEC and AbdoMan phantoms, mimicking human liver) filled with Y-90 and a 4:1 sphere (tumor)-to-background ratio were scanned for 24 h with the Biograph Vision Quadra (Siemens Healthineers). Eight patients were scanned after Y-90 radioembolization (1.3–4.7 GBq) using the optimized protocol (obtained by phantom studies). The IQ, contrast recovery coefficients (CRCs) and noise were evaluated for their limited and full acceptance angles, different rebinned scan durations, numbers of iterations and post-reconstruction filters. The s-value-based absorbed doses were calculated to assess their suitability for dosimetry. Results: The phantom studies demonstrate that two iterations, five subsets and a 4 mm Gaussian filter provide a reasonable compromise between a high CRC and low noise. For a 20 min scan duration, an adequate CRC of 56% (vs. 24 h: 62%, 20 mm sphere) was obtained, and the noise was reduced by a factor of 1.4, from 40% to 29%, using the full acceptance angle. The patient scan results were consistent with those from the phantom studies, and the impacts on the absorbed doses were negligible for all of the studied parameter sets, as the maximum percentage difference was −3.89%. Conclusions: With 2i5s, a 4 mm filter and a scan duration of 20 min, IQ and quantification accuracy that are suitable for post-treatment dosimetry of Y-90 radioembolization can be achieved.
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spelling pubmed-106700482023-11-09 Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner Linder, Pia M. Lan, Wenhong Trautwein, Nils F. Brosch-Lenz, Julia von Beschwitz, Sebastian Kupferschläger, Jürgen Reischl, Gerald Grözinger, Gerd Dittmann, Helmut la Fougère, Christian Schmidt, Fabian P. Diagnostics (Basel) Article Background: PET imaging after yttrium-90 (Y-90) radioembolization is challenging because of the low positron fraction of Y-90 (32 × 10(−6)). The resulting low number of events can be compensated by the high sensitivity of long axial field-of-view (LAFOV) PET/CT scanners. Nevertheless, the reduced event statistics require optimization of the imaging protocol to achieve high image quality (IQ) and quantification accuracy sufficient for post-treatment dosimetry. Methods: Two phantoms (NEMA IEC and AbdoMan phantoms, mimicking human liver) filled with Y-90 and a 4:1 sphere (tumor)-to-background ratio were scanned for 24 h with the Biograph Vision Quadra (Siemens Healthineers). Eight patients were scanned after Y-90 radioembolization (1.3–4.7 GBq) using the optimized protocol (obtained by phantom studies). The IQ, contrast recovery coefficients (CRCs) and noise were evaluated for their limited and full acceptance angles, different rebinned scan durations, numbers of iterations and post-reconstruction filters. The s-value-based absorbed doses were calculated to assess their suitability for dosimetry. Results: The phantom studies demonstrate that two iterations, five subsets and a 4 mm Gaussian filter provide a reasonable compromise between a high CRC and low noise. For a 20 min scan duration, an adequate CRC of 56% (vs. 24 h: 62%, 20 mm sphere) was obtained, and the noise was reduced by a factor of 1.4, from 40% to 29%, using the full acceptance angle. The patient scan results were consistent with those from the phantom studies, and the impacts on the absorbed doses were negligible for all of the studied parameter sets, as the maximum percentage difference was −3.89%. Conclusions: With 2i5s, a 4 mm filter and a scan duration of 20 min, IQ and quantification accuracy that are suitable for post-treatment dosimetry of Y-90 radioembolization can be achieved. MDPI 2023-11-09 /pmc/articles/PMC10670048/ /pubmed/37998554 http://dx.doi.org/10.3390/diagnostics13223418 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Linder, Pia M.
Lan, Wenhong
Trautwein, Nils F.
Brosch-Lenz, Julia
von Beschwitz, Sebastian
Kupferschläger, Jürgen
Reischl, Gerald
Grözinger, Gerd
Dittmann, Helmut
la Fougère, Christian
Schmidt, Fabian P.
Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner
title Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner
title_full Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner
title_fullStr Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner
title_full_unstemmed Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner
title_short Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner
title_sort optimization of y-90 radioembolization imaging for post-treatment dosimetry on a long axial field-of-view pet/ct scanner
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670048/
https://www.ncbi.nlm.nih.gov/pubmed/37998554
http://dx.doi.org/10.3390/diagnostics13223418
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