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The Response of the Replication Apparatus to Leading Template Strand Blocks

Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand. Replisomes consist of two functional units, a helicase to unwind DNA and polymerases to synthesize it. T...

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Detalles Bibliográficos
Autores principales:	Bellani, Marina A., Shaik, Althaf, Majumdar, Ishani, Ling, Chen, Seidman, Michael M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670059/ https://www.ncbi.nlm.nih.gov/pubmed/37998342 http://dx.doi.org/10.3390/cells12222607

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