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Sonographic Aeration Scoring Indicates Disease Severity in Critically Ill Patients with COVID-19

Aims and Methods: We evaluated an ultrasound score from 0 to 32 points in eight pulmonary regions to monitor critically ill COVID-19 patients. The score was correlated to surrogate parameters of disease severity, i.e., the oxygenation index, respiratory support, mortality, plasma interleukin-6, and...

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Autores principales: Marggrander, Daniel T., Simon, Philippe, Schröder, Tobias, Gill-Schuster, Daniel, Mutlak, Haitham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670098/
https://www.ncbi.nlm.nih.gov/pubmed/37998582
http://dx.doi.org/10.3390/diagnostics13223446
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author Marggrander, Daniel T.
Simon, Philippe
Schröder, Tobias
Gill-Schuster, Daniel
Mutlak, Haitham
author_facet Marggrander, Daniel T.
Simon, Philippe
Schröder, Tobias
Gill-Schuster, Daniel
Mutlak, Haitham
author_sort Marggrander, Daniel T.
collection PubMed
description Aims and Methods: We evaluated an ultrasound score from 0 to 32 points in eight pulmonary regions to monitor critically ill COVID-19 patients. The score was correlated to surrogate parameters of disease severity, i.e., the oxygenation index, respiratory support, mortality, plasma interleukin-6, and WHO and ARDS classifications. Results: A total of 27 patients were repeatedly examined, and 71 examinations were evaluated. Patients with severe COVID-19 scored higher (median 17) than those with moderate disease (median 11, p < 0.01). The score did not differentiate between stages of ARDS as defined by the Berlin criteria (p = 0.1) but could discern ARDS according to the revised ESICM definition (p = 0.002). Non-survivors had higher ultrasound scores than survivors (median 18.5 vs. 14, p = 0.04). The score correlated to the oxygenation index (ρ = −0.56, p = 0.03), and changes in the score between examinations correlated to changes in oxygenation (ρ = −0.41, p = 0.16). The correlation between the score and interleukin-6 was ρ = 0.35 (p < 0.001). The interrater reliability for the score was ICC = 0.87 (p < 0.001). Conclusions: The ultrasound score is a reliable tool that might help monitor disease severity and may help stratify the risk of mortality.
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spelling pubmed-106700982023-11-15 Sonographic Aeration Scoring Indicates Disease Severity in Critically Ill Patients with COVID-19 Marggrander, Daniel T. Simon, Philippe Schröder, Tobias Gill-Schuster, Daniel Mutlak, Haitham Diagnostics (Basel) Brief Report Aims and Methods: We evaluated an ultrasound score from 0 to 32 points in eight pulmonary regions to monitor critically ill COVID-19 patients. The score was correlated to surrogate parameters of disease severity, i.e., the oxygenation index, respiratory support, mortality, plasma interleukin-6, and WHO and ARDS classifications. Results: A total of 27 patients were repeatedly examined, and 71 examinations were evaluated. Patients with severe COVID-19 scored higher (median 17) than those with moderate disease (median 11, p < 0.01). The score did not differentiate between stages of ARDS as defined by the Berlin criteria (p = 0.1) but could discern ARDS according to the revised ESICM definition (p = 0.002). Non-survivors had higher ultrasound scores than survivors (median 18.5 vs. 14, p = 0.04). The score correlated to the oxygenation index (ρ = −0.56, p = 0.03), and changes in the score between examinations correlated to changes in oxygenation (ρ = −0.41, p = 0.16). The correlation between the score and interleukin-6 was ρ = 0.35 (p < 0.001). The interrater reliability for the score was ICC = 0.87 (p < 0.001). Conclusions: The ultrasound score is a reliable tool that might help monitor disease severity and may help stratify the risk of mortality. MDPI 2023-11-15 /pmc/articles/PMC10670098/ /pubmed/37998582 http://dx.doi.org/10.3390/diagnostics13223446 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Marggrander, Daniel T.
Simon, Philippe
Schröder, Tobias
Gill-Schuster, Daniel
Mutlak, Haitham
Sonographic Aeration Scoring Indicates Disease Severity in Critically Ill Patients with COVID-19
title Sonographic Aeration Scoring Indicates Disease Severity in Critically Ill Patients with COVID-19
title_full Sonographic Aeration Scoring Indicates Disease Severity in Critically Ill Patients with COVID-19
title_fullStr Sonographic Aeration Scoring Indicates Disease Severity in Critically Ill Patients with COVID-19
title_full_unstemmed Sonographic Aeration Scoring Indicates Disease Severity in Critically Ill Patients with COVID-19
title_short Sonographic Aeration Scoring Indicates Disease Severity in Critically Ill Patients with COVID-19
title_sort sonographic aeration scoring indicates disease severity in critically ill patients with covid-19
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670098/
https://www.ncbi.nlm.nih.gov/pubmed/37998582
http://dx.doi.org/10.3390/diagnostics13223446
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