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Autophagy Modulation and Its Implications on Glioblastoma Treatment
Autophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of au...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670099/ https://www.ncbi.nlm.nih.gov/pubmed/37998723 http://dx.doi.org/10.3390/cimb45110546 |
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author | Chen, Johnny Rodriguez, Andrea Salinas Morales, Maximiliano Arath Fang, Xiaoqian |
author_facet | Chen, Johnny Rodriguez, Andrea Salinas Morales, Maximiliano Arath Fang, Xiaoqian |
author_sort | Chen, Johnny |
collection | PubMed |
description | Autophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of autophagy has been associated with many diseases, such as neurodegenerative disorders and cancer. This review will center its discussion on providing an in-depth analysis of the current molecular understanding of autophagy and its relevance to brain tumors. We will delve into the current literature regarding the role of autophagy in glioma pathogenesis by exploring the major pathways of JAK2/STAT3 and PI3K/AKT/mTOR and summarizing the current therapeutic interventions and strategies for glioma treatment. These treatments will be evaluated on their potential for autophagy induction and the challenges associated with their utilization. By understanding the mechanism of autophagy, clinical applications for future therapeutics in treating gliomas can be better targeted. |
format | Online Article Text |
id | pubmed-10670099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106700992023-10-29 Autophagy Modulation and Its Implications on Glioblastoma Treatment Chen, Johnny Rodriguez, Andrea Salinas Morales, Maximiliano Arath Fang, Xiaoqian Curr Issues Mol Biol Review Autophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of autophagy has been associated with many diseases, such as neurodegenerative disorders and cancer. This review will center its discussion on providing an in-depth analysis of the current molecular understanding of autophagy and its relevance to brain tumors. We will delve into the current literature regarding the role of autophagy in glioma pathogenesis by exploring the major pathways of JAK2/STAT3 and PI3K/AKT/mTOR and summarizing the current therapeutic interventions and strategies for glioma treatment. These treatments will be evaluated on their potential for autophagy induction and the challenges associated with their utilization. By understanding the mechanism of autophagy, clinical applications for future therapeutics in treating gliomas can be better targeted. MDPI 2023-10-29 /pmc/articles/PMC10670099/ /pubmed/37998723 http://dx.doi.org/10.3390/cimb45110546 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Johnny Rodriguez, Andrea Salinas Morales, Maximiliano Arath Fang, Xiaoqian Autophagy Modulation and Its Implications on Glioblastoma Treatment |
title | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
title_full | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
title_fullStr | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
title_full_unstemmed | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
title_short | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
title_sort | autophagy modulation and its implications on glioblastoma treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670099/ https://www.ncbi.nlm.nih.gov/pubmed/37998723 http://dx.doi.org/10.3390/cimb45110546 |
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