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The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases

Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis...

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Autores principales: Maranduca, Minela Aida, Cosovanu, Mihai Andrei, Clim, Andreea, Pinzariu, Alin Constantin, Filip, Nina, Drochioi, Ilie Cristian, Vlasceanu, Vlad Ionut, Timofte, Daniel Vasile, Nemteanu, Roxana, Plesa, Alina, Pertea, Mihaela, Serban, Ionela Lacramioara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670244/
https://www.ncbi.nlm.nih.gov/pubmed/37998534
http://dx.doi.org/10.3390/diagnostics13223398
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author Maranduca, Minela Aida
Cosovanu, Mihai Andrei
Clim, Andreea
Pinzariu, Alin Constantin
Filip, Nina
Drochioi, Ilie Cristian
Vlasceanu, Vlad Ionut
Timofte, Daniel Vasile
Nemteanu, Roxana
Plesa, Alina
Pertea, Mihaela
Serban, Ionela Lacramioara
author_facet Maranduca, Minela Aida
Cosovanu, Mihai Andrei
Clim, Andreea
Pinzariu, Alin Constantin
Filip, Nina
Drochioi, Ilie Cristian
Vlasceanu, Vlad Ionut
Timofte, Daniel Vasile
Nemteanu, Roxana
Plesa, Alina
Pertea, Mihaela
Serban, Ionela Lacramioara
author_sort Maranduca, Minela Aida
collection PubMed
description Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis and progression of these conditions. RAS is a multicomponent cascade, primarily known for its role in regulating blood pressure and fluid balance. All of the RAS components play an important role in controlling inflammation and other immune responses. Angiotensin II, the main effector, acts on two essential receptors: Angiotensin Receptor 1 and 2 (AT1R and AT2R). A disturbance in the axis can lead to many pathological processes, including autoimmune (AI) diseases. AT1R activation triggers diverse signaling cascades involved in inflammation, fibrosis and tissue remodeling. Experimental studies have demonstrated the presence of AT1R in various cutaneous cells and immune cells, further emphasizing its potential contribution to the AI processes in the skin. Furthermore, recent investigations have highlighted the role of other RAS components, beyond angiotensin-converting enzyme (ACE) and Ang II, that may contribute to the pathophysiology of AIDD. Alternative pathways involving ACE2, Ang receptors and Ang-(1-7) have been implicated in regulating immune responses and tissue homeostasis within the skin microenvironment. Understanding the intricate involvement of the RAS in AIDD may provide novel therapeutic opportunities. Targeting specific components of the RAS, such as angiotensin receptor blockers (ARBs), ACE inhibitors (ACEIs) or alternative RAS pathway modulators, could potentially ameliorate inflammatory responses, reduce tissue damage and lessen disease manifestations. Further research is warranted to outline the exact mechanisms underlying RAS-mediated immune dysregulation in AIDD. This abstract aims to provide a concise overview of the intricate interplay between the RAS and AIDD. Therefore, we elaborate a systematic review of the potential challenge of RAS in the AIDD, including psoriasis, systemic sclerosis, vitiligo, lupus erythematosus and many more.
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spelling pubmed-106702442023-11-07 The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases Maranduca, Minela Aida Cosovanu, Mihai Andrei Clim, Andreea Pinzariu, Alin Constantin Filip, Nina Drochioi, Ilie Cristian Vlasceanu, Vlad Ionut Timofte, Daniel Vasile Nemteanu, Roxana Plesa, Alina Pertea, Mihaela Serban, Ionela Lacramioara Diagnostics (Basel) Review Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis and progression of these conditions. RAS is a multicomponent cascade, primarily known for its role in regulating blood pressure and fluid balance. All of the RAS components play an important role in controlling inflammation and other immune responses. Angiotensin II, the main effector, acts on two essential receptors: Angiotensin Receptor 1 and 2 (AT1R and AT2R). A disturbance in the axis can lead to many pathological processes, including autoimmune (AI) diseases. AT1R activation triggers diverse signaling cascades involved in inflammation, fibrosis and tissue remodeling. Experimental studies have demonstrated the presence of AT1R in various cutaneous cells and immune cells, further emphasizing its potential contribution to the AI processes in the skin. Furthermore, recent investigations have highlighted the role of other RAS components, beyond angiotensin-converting enzyme (ACE) and Ang II, that may contribute to the pathophysiology of AIDD. Alternative pathways involving ACE2, Ang receptors and Ang-(1-7) have been implicated in regulating immune responses and tissue homeostasis within the skin microenvironment. Understanding the intricate involvement of the RAS in AIDD may provide novel therapeutic opportunities. Targeting specific components of the RAS, such as angiotensin receptor blockers (ARBs), ACE inhibitors (ACEIs) or alternative RAS pathway modulators, could potentially ameliorate inflammatory responses, reduce tissue damage and lessen disease manifestations. Further research is warranted to outline the exact mechanisms underlying RAS-mediated immune dysregulation in AIDD. This abstract aims to provide a concise overview of the intricate interplay between the RAS and AIDD. Therefore, we elaborate a systematic review of the potential challenge of RAS in the AIDD, including psoriasis, systemic sclerosis, vitiligo, lupus erythematosus and many more. MDPI 2023-11-07 /pmc/articles/PMC10670244/ /pubmed/37998534 http://dx.doi.org/10.3390/diagnostics13223398 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maranduca, Minela Aida
Cosovanu, Mihai Andrei
Clim, Andreea
Pinzariu, Alin Constantin
Filip, Nina
Drochioi, Ilie Cristian
Vlasceanu, Vlad Ionut
Timofte, Daniel Vasile
Nemteanu, Roxana
Plesa, Alina
Pertea, Mihaela
Serban, Ionela Lacramioara
The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases
title The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases
title_full The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases
title_fullStr The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases
title_full_unstemmed The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases
title_short The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases
title_sort renin-angiotensin system: the challenge behind autoimmune dermatological diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670244/
https://www.ncbi.nlm.nih.gov/pubmed/37998534
http://dx.doi.org/10.3390/diagnostics13223398
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