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The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases
Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670244/ https://www.ncbi.nlm.nih.gov/pubmed/37998534 http://dx.doi.org/10.3390/diagnostics13223398 |
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author | Maranduca, Minela Aida Cosovanu, Mihai Andrei Clim, Andreea Pinzariu, Alin Constantin Filip, Nina Drochioi, Ilie Cristian Vlasceanu, Vlad Ionut Timofte, Daniel Vasile Nemteanu, Roxana Plesa, Alina Pertea, Mihaela Serban, Ionela Lacramioara |
author_facet | Maranduca, Minela Aida Cosovanu, Mihai Andrei Clim, Andreea Pinzariu, Alin Constantin Filip, Nina Drochioi, Ilie Cristian Vlasceanu, Vlad Ionut Timofte, Daniel Vasile Nemteanu, Roxana Plesa, Alina Pertea, Mihaela Serban, Ionela Lacramioara |
author_sort | Maranduca, Minela Aida |
collection | PubMed |
description | Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis and progression of these conditions. RAS is a multicomponent cascade, primarily known for its role in regulating blood pressure and fluid balance. All of the RAS components play an important role in controlling inflammation and other immune responses. Angiotensin II, the main effector, acts on two essential receptors: Angiotensin Receptor 1 and 2 (AT1R and AT2R). A disturbance in the axis can lead to many pathological processes, including autoimmune (AI) diseases. AT1R activation triggers diverse signaling cascades involved in inflammation, fibrosis and tissue remodeling. Experimental studies have demonstrated the presence of AT1R in various cutaneous cells and immune cells, further emphasizing its potential contribution to the AI processes in the skin. Furthermore, recent investigations have highlighted the role of other RAS components, beyond angiotensin-converting enzyme (ACE) and Ang II, that may contribute to the pathophysiology of AIDD. Alternative pathways involving ACE2, Ang receptors and Ang-(1-7) have been implicated in regulating immune responses and tissue homeostasis within the skin microenvironment. Understanding the intricate involvement of the RAS in AIDD may provide novel therapeutic opportunities. Targeting specific components of the RAS, such as angiotensin receptor blockers (ARBs), ACE inhibitors (ACEIs) or alternative RAS pathway modulators, could potentially ameliorate inflammatory responses, reduce tissue damage and lessen disease manifestations. Further research is warranted to outline the exact mechanisms underlying RAS-mediated immune dysregulation in AIDD. This abstract aims to provide a concise overview of the intricate interplay between the RAS and AIDD. Therefore, we elaborate a systematic review of the potential challenge of RAS in the AIDD, including psoriasis, systemic sclerosis, vitiligo, lupus erythematosus and many more. |
format | Online Article Text |
id | pubmed-10670244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106702442023-11-07 The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases Maranduca, Minela Aida Cosovanu, Mihai Andrei Clim, Andreea Pinzariu, Alin Constantin Filip, Nina Drochioi, Ilie Cristian Vlasceanu, Vlad Ionut Timofte, Daniel Vasile Nemteanu, Roxana Plesa, Alina Pertea, Mihaela Serban, Ionela Lacramioara Diagnostics (Basel) Review Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis and progression of these conditions. RAS is a multicomponent cascade, primarily known for its role in regulating blood pressure and fluid balance. All of the RAS components play an important role in controlling inflammation and other immune responses. Angiotensin II, the main effector, acts on two essential receptors: Angiotensin Receptor 1 and 2 (AT1R and AT2R). A disturbance in the axis can lead to many pathological processes, including autoimmune (AI) diseases. AT1R activation triggers diverse signaling cascades involved in inflammation, fibrosis and tissue remodeling. Experimental studies have demonstrated the presence of AT1R in various cutaneous cells and immune cells, further emphasizing its potential contribution to the AI processes in the skin. Furthermore, recent investigations have highlighted the role of other RAS components, beyond angiotensin-converting enzyme (ACE) and Ang II, that may contribute to the pathophysiology of AIDD. Alternative pathways involving ACE2, Ang receptors and Ang-(1-7) have been implicated in regulating immune responses and tissue homeostasis within the skin microenvironment. Understanding the intricate involvement of the RAS in AIDD may provide novel therapeutic opportunities. Targeting specific components of the RAS, such as angiotensin receptor blockers (ARBs), ACE inhibitors (ACEIs) or alternative RAS pathway modulators, could potentially ameliorate inflammatory responses, reduce tissue damage and lessen disease manifestations. Further research is warranted to outline the exact mechanisms underlying RAS-mediated immune dysregulation in AIDD. This abstract aims to provide a concise overview of the intricate interplay between the RAS and AIDD. Therefore, we elaborate a systematic review of the potential challenge of RAS in the AIDD, including psoriasis, systemic sclerosis, vitiligo, lupus erythematosus and many more. MDPI 2023-11-07 /pmc/articles/PMC10670244/ /pubmed/37998534 http://dx.doi.org/10.3390/diagnostics13223398 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maranduca, Minela Aida Cosovanu, Mihai Andrei Clim, Andreea Pinzariu, Alin Constantin Filip, Nina Drochioi, Ilie Cristian Vlasceanu, Vlad Ionut Timofte, Daniel Vasile Nemteanu, Roxana Plesa, Alina Pertea, Mihaela Serban, Ionela Lacramioara The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases |
title | The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases |
title_full | The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases |
title_fullStr | The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases |
title_full_unstemmed | The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases |
title_short | The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases |
title_sort | renin-angiotensin system: the challenge behind autoimmune dermatological diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670244/ https://www.ncbi.nlm.nih.gov/pubmed/37998534 http://dx.doi.org/10.3390/diagnostics13223398 |
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