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Bridging the Divide: Brain and Behavior in Developmental Language Disorder

Developmental language disorder (DLD) is a heterogenous neurodevelopmental disorder that affects a child’s ability to comprehend and/or produce spoken and/or written language, yet it cannot be attributed to hearing loss or overt neurological damage. It is widely believed that some combination of gen...

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Detalles Bibliográficos
Autores principales: Abbott, Noelle, Love, Tracy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670267/
https://www.ncbi.nlm.nih.gov/pubmed/38002565
http://dx.doi.org/10.3390/brainsci13111606
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author Abbott, Noelle
Love, Tracy
author_facet Abbott, Noelle
Love, Tracy
author_sort Abbott, Noelle
collection PubMed
description Developmental language disorder (DLD) is a heterogenous neurodevelopmental disorder that affects a child’s ability to comprehend and/or produce spoken and/or written language, yet it cannot be attributed to hearing loss or overt neurological damage. It is widely believed that some combination of genetic, biological, and environmental factors influences brain and language development in this population, but it has been difficult to bridge theoretical accounts of DLD with neuroimaging findings, due to heterogeneity in language impairment profiles across individuals and inconsistent neuroimaging findings. Therefore, the purpose of this overview is two-fold: (1) to summarize the neuroimaging literature (while drawing on findings from other language-impaired populations, where appropriate); and (2) to briefly review the theoretical accounts of language impairment patterns in DLD, with the goal of bridging the disparate findings. As will be demonstrated with this overview, the current state of the field suggests that children with DLD have atypical brain volume, laterality, and activation/connectivity patterns in key language regions that likely contribute to language difficulties. However, the precise nature of these differences and the underlying neural mechanisms contributing to them remain an open area of investigation.
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spelling pubmed-106702672023-11-19 Bridging the Divide: Brain and Behavior in Developmental Language Disorder Abbott, Noelle Love, Tracy Brain Sci Review Developmental language disorder (DLD) is a heterogenous neurodevelopmental disorder that affects a child’s ability to comprehend and/or produce spoken and/or written language, yet it cannot be attributed to hearing loss or overt neurological damage. It is widely believed that some combination of genetic, biological, and environmental factors influences brain and language development in this population, but it has been difficult to bridge theoretical accounts of DLD with neuroimaging findings, due to heterogeneity in language impairment profiles across individuals and inconsistent neuroimaging findings. Therefore, the purpose of this overview is two-fold: (1) to summarize the neuroimaging literature (while drawing on findings from other language-impaired populations, where appropriate); and (2) to briefly review the theoretical accounts of language impairment patterns in DLD, with the goal of bridging the disparate findings. As will be demonstrated with this overview, the current state of the field suggests that children with DLD have atypical brain volume, laterality, and activation/connectivity patterns in key language regions that likely contribute to language difficulties. However, the precise nature of these differences and the underlying neural mechanisms contributing to them remain an open area of investigation. MDPI 2023-11-19 /pmc/articles/PMC10670267/ /pubmed/38002565 http://dx.doi.org/10.3390/brainsci13111606 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abbott, Noelle
Love, Tracy
Bridging the Divide: Brain and Behavior in Developmental Language Disorder
title Bridging the Divide: Brain and Behavior in Developmental Language Disorder
title_full Bridging the Divide: Brain and Behavior in Developmental Language Disorder
title_fullStr Bridging the Divide: Brain and Behavior in Developmental Language Disorder
title_full_unstemmed Bridging the Divide: Brain and Behavior in Developmental Language Disorder
title_short Bridging the Divide: Brain and Behavior in Developmental Language Disorder
title_sort bridging the divide: brain and behavior in developmental language disorder
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670267/
https://www.ncbi.nlm.nih.gov/pubmed/38002565
http://dx.doi.org/10.3390/brainsci13111606
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