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The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis
Background: Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease with rising incidence. While proton pump inhibitors (PPIs) are the first-line treatment, a significant proportion of patients do not respond. This study aimed to determine if the EoE Histology Scoring System (EoEHSS)...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670290/ https://www.ncbi.nlm.nih.gov/pubmed/37998581 http://dx.doi.org/10.3390/diagnostics13223445 |
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author | Jevtić, Jovan Ristić, Nina Pavlović, Vedrana Svorcan, Jovana Milovanovich, Ivan Radusinović, Milica Popovac, Nevena Simić, Ljubica Ćirović, Aleksandar Đuknić, Miloš Životić, Maja Poljašević, Nevena Obradović, Danilo Filipović, Jelena Janković, Radmila |
author_facet | Jevtić, Jovan Ristić, Nina Pavlović, Vedrana Svorcan, Jovana Milovanovich, Ivan Radusinović, Milica Popovac, Nevena Simić, Ljubica Ćirović, Aleksandar Đuknić, Miloš Životić, Maja Poljašević, Nevena Obradović, Danilo Filipović, Jelena Janković, Radmila |
author_sort | Jevtić, Jovan |
collection | PubMed |
description | Background: Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease with rising incidence. While proton pump inhibitors (PPIs) are the first-line treatment, a significant proportion of patients do not respond. This study aimed to determine if the EoE Histology Scoring System (EoEHSS) can predict PPI responsiveness. Methods: A cross-sectional study was conducted on 89 pediatric patients diagnosed with EoE between 2016 and 2022. Patients were categorized into PPI responders (PPIREoE) and non-responders (PPINREoE) based on post-treatment biopsies. EoEHSS values from biopsies of the esophagus (distal, middle, and proximal segments) were compared between the two groups. Results: No significant differences in EoEHSS scores were observed for the distal and proximal esophagus between the groups. However, the middle esophagus showed a significantly higher EoEHSS grade score in the PPINREoE group, indicating a more pronounced disease severity. Specific histological features, particularly eosinophilic abscesses and surface layering of the middle segment of the esophagus, were significantly different between the groups. Conclusions: Performing a biopsy of each esophageal segment, particularly the middle, is crucial for diagnostic precision and predicting PPI responsiveness. The EoEHSS can serve as a valuable tool in predicting therapy response, emphasizing the need for personalized therapeutic approaches in EoE management. |
format | Online Article Text |
id | pubmed-10670290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106702902023-11-15 The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis Jevtić, Jovan Ristić, Nina Pavlović, Vedrana Svorcan, Jovana Milovanovich, Ivan Radusinović, Milica Popovac, Nevena Simić, Ljubica Ćirović, Aleksandar Đuknić, Miloš Životić, Maja Poljašević, Nevena Obradović, Danilo Filipović, Jelena Janković, Radmila Diagnostics (Basel) Article Background: Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease with rising incidence. While proton pump inhibitors (PPIs) are the first-line treatment, a significant proportion of patients do not respond. This study aimed to determine if the EoE Histology Scoring System (EoEHSS) can predict PPI responsiveness. Methods: A cross-sectional study was conducted on 89 pediatric patients diagnosed with EoE between 2016 and 2022. Patients were categorized into PPI responders (PPIREoE) and non-responders (PPINREoE) based on post-treatment biopsies. EoEHSS values from biopsies of the esophagus (distal, middle, and proximal segments) were compared between the two groups. Results: No significant differences in EoEHSS scores were observed for the distal and proximal esophagus between the groups. However, the middle esophagus showed a significantly higher EoEHSS grade score in the PPINREoE group, indicating a more pronounced disease severity. Specific histological features, particularly eosinophilic abscesses and surface layering of the middle segment of the esophagus, were significantly different between the groups. Conclusions: Performing a biopsy of each esophageal segment, particularly the middle, is crucial for diagnostic precision and predicting PPI responsiveness. The EoEHSS can serve as a valuable tool in predicting therapy response, emphasizing the need for personalized therapeutic approaches in EoE management. MDPI 2023-11-15 /pmc/articles/PMC10670290/ /pubmed/37998581 http://dx.doi.org/10.3390/diagnostics13223445 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jevtić, Jovan Ristić, Nina Pavlović, Vedrana Svorcan, Jovana Milovanovich, Ivan Radusinović, Milica Popovac, Nevena Simić, Ljubica Ćirović, Aleksandar Đuknić, Miloš Životić, Maja Poljašević, Nevena Obradović, Danilo Filipović, Jelena Janković, Radmila The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis |
title | The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis |
title_full | The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis |
title_fullStr | The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis |
title_full_unstemmed | The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis |
title_short | The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis |
title_sort | usefulness of the eosinophilic esophagitis histology scoring system in predicting response to proton pump inhibitor monotherapy in children with eosinophilic esophagitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670290/ https://www.ncbi.nlm.nih.gov/pubmed/37998581 http://dx.doi.org/10.3390/diagnostics13223445 |
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