Overcoming Immune Checkpoint Therapy Resistance with SHP2 Inhibition in Cancer and Immune Cells: A Review of the Literature and Novel Combinatorial Approaches

SIMPLE SUMMARY: This is a thorough literature review of SHP2 inhibition, its application in cancer therapy and current uses as an immune modulator. The aberrant activation of SHP2, a protein tyrosine phosphatase widely expressed in many cell types, is implicated in multiple human cancers. As SHP2 is...

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Detalles Bibliográficos
Autores principales: Tojjari, Alireza, Saeed, Anwaar, Sadeghipour, Arezoo, Kurzrock, Razelle, Cavalcante, Ludimila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670368/
https://www.ncbi.nlm.nih.gov/pubmed/38001644
http://dx.doi.org/10.3390/cancers15225384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670368/
https://www.ncbi.nlm.nih.gov/pubmed/38001644
http://dx.doi.org/10.3390/cancers15225384

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