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Chromophore-Targeting Precision Antimicrobial Phototherapy
Phototherapy, encompassing the utilization of both natural and artificial light, has emerged as a dependable and non-invasive strategy for addressing a diverse range of illnesses, diseases, and infections. This therapeutic approach, primarily known for its efficacy in treating skin infections, such...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670386/ https://www.ncbi.nlm.nih.gov/pubmed/37998399 http://dx.doi.org/10.3390/cells12222664 |
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author | Jusuf, Sebastian Dong, Pu-Ting |
author_facet | Jusuf, Sebastian Dong, Pu-Ting |
author_sort | Jusuf, Sebastian |
collection | PubMed |
description | Phototherapy, encompassing the utilization of both natural and artificial light, has emerged as a dependable and non-invasive strategy for addressing a diverse range of illnesses, diseases, and infections. This therapeutic approach, primarily known for its efficacy in treating skin infections, such as herpes and acne lesions, involves the synergistic use of specific light wavelengths and photosensitizers, like methylene blue. Photodynamic therapy, as it is termed, relies on the generation of antimicrobial reactive oxygen species (ROS) through the interaction between light and externally applied photosensitizers. Recent research, however, has highlighted the intrinsic antimicrobial properties of light itself, marking a paradigm shift in focus from exogenous agents to the inherent photosensitivity of molecules found naturally within pathogens. Chemical analyses have identified specific organic molecular structures and systems, including protoporphyrins and conjugated C=C bonds, as pivotal components in molecular photosensitivity. Given the prevalence of these systems in organic life forms, there is an urgent need to investigate the potential impact of phototherapy on individual molecules expressed within pathogens and discern their contributions to the antimicrobial effects of light. This review delves into the recently unveiled key molecular targets of phototherapy, offering insights into their potential downstream implications and therapeutic applications. By shedding light on these fundamental molecular mechanisms, we aim to advance our understanding of phototherapy’s broader therapeutic potential and contribute to the development of innovative treatments for a wide array of microbial infections and diseases. |
format | Online Article Text |
id | pubmed-10670386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106703862023-11-20 Chromophore-Targeting Precision Antimicrobial Phototherapy Jusuf, Sebastian Dong, Pu-Ting Cells Review Phototherapy, encompassing the utilization of both natural and artificial light, has emerged as a dependable and non-invasive strategy for addressing a diverse range of illnesses, diseases, and infections. This therapeutic approach, primarily known for its efficacy in treating skin infections, such as herpes and acne lesions, involves the synergistic use of specific light wavelengths and photosensitizers, like methylene blue. Photodynamic therapy, as it is termed, relies on the generation of antimicrobial reactive oxygen species (ROS) through the interaction between light and externally applied photosensitizers. Recent research, however, has highlighted the intrinsic antimicrobial properties of light itself, marking a paradigm shift in focus from exogenous agents to the inherent photosensitivity of molecules found naturally within pathogens. Chemical analyses have identified specific organic molecular structures and systems, including protoporphyrins and conjugated C=C bonds, as pivotal components in molecular photosensitivity. Given the prevalence of these systems in organic life forms, there is an urgent need to investigate the potential impact of phototherapy on individual molecules expressed within pathogens and discern their contributions to the antimicrobial effects of light. This review delves into the recently unveiled key molecular targets of phototherapy, offering insights into their potential downstream implications and therapeutic applications. By shedding light on these fundamental molecular mechanisms, we aim to advance our understanding of phototherapy’s broader therapeutic potential and contribute to the development of innovative treatments for a wide array of microbial infections and diseases. MDPI 2023-11-20 /pmc/articles/PMC10670386/ /pubmed/37998399 http://dx.doi.org/10.3390/cells12222664 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jusuf, Sebastian Dong, Pu-Ting Chromophore-Targeting Precision Antimicrobial Phototherapy |
title | Chromophore-Targeting Precision Antimicrobial Phototherapy |
title_full | Chromophore-Targeting Precision Antimicrobial Phototherapy |
title_fullStr | Chromophore-Targeting Precision Antimicrobial Phototherapy |
title_full_unstemmed | Chromophore-Targeting Precision Antimicrobial Phototherapy |
title_short | Chromophore-Targeting Precision Antimicrobial Phototherapy |
title_sort | chromophore-targeting precision antimicrobial phototherapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670386/ https://www.ncbi.nlm.nih.gov/pubmed/37998399 http://dx.doi.org/10.3390/cells12222664 |
work_keys_str_mv | AT jusufsebastian chromophoretargetingprecisionantimicrobialphototherapy AT dongputing chromophoretargetingprecisionantimicrobialphototherapy |