Cargando…

Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children

The accurate prediction of the prognosis for critically ill children is crucial, with the Pediatric Index of Mortality (PIM) and Pediatric Risk of Mortality (PRISM) being extensively utilized for this purpose. Albumin, C-reactive protein (CRP), and lactate levels, which are indicative of inflammatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Arslan, Gazi, Besci, Tolga, Özdemir, Göktuğ, Evren, Gültaç, Ilgaz Tüzen, Hande, Prencuva, Pınar, Turan, Bengisu, Benligül, Ebru Melek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670452/
https://www.ncbi.nlm.nih.gov/pubmed/38002822
http://dx.doi.org/10.3390/children10111731
_version_ 1785139926410461184
author Arslan, Gazi
Besci, Tolga
Özdemir, Göktuğ
Evren, Gültaç
Ilgaz Tüzen, Hande
Prencuva, Pınar
Turan, Bengisu
Benligül, Ebru Melek
author_facet Arslan, Gazi
Besci, Tolga
Özdemir, Göktuğ
Evren, Gültaç
Ilgaz Tüzen, Hande
Prencuva, Pınar
Turan, Bengisu
Benligül, Ebru Melek
author_sort Arslan, Gazi
collection PubMed
description The accurate prediction of the prognosis for critically ill children is crucial, with the Pediatric Index of Mortality (PIM) and Pediatric Risk of Mortality (PRISM) being extensively utilized for this purpose. Albumin, C-reactive protein (CRP), and lactate levels, which are indicative of inflammation and circulatory status in critically ill children, have not been incorporated into existing scoring systems. This retrospective cohort study evaluated the association between biological markers and the clinical outcomes in children with critical illnesses. PRISM-4 and PIM-3 death probability (DP), albumin, lactate, CRP, and CRP/albumin ratio were recorded upon admission. The accuracy of the indexes in predicting mortality were assessed by calculating the area under the curve (AUC). There were 942 patients included and the 28-day mortality rate was 7.9%. The AUC for PRISM-4, PIM-3, CRP, CRP/albumin ratio, albumin, and lactate were 0.923, 0.896, 0.798, 0.795, 0.751, 0.728, respectively. The findings in the subgroup analysis of septic patients were similar to those found in the overall population. Although CRP, CRP/albumin ratio, albumin, and lactate levels are all linked to mortality in children, CRP and the CRP/albumin ratio have lower predictive values than albumin and lactate. Incorporation of albumin and lactate into scoring systems will improve predictability.
format Online
Article
Text
id pubmed-10670452
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106704522023-10-26 Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children Arslan, Gazi Besci, Tolga Özdemir, Göktuğ Evren, Gültaç Ilgaz Tüzen, Hande Prencuva, Pınar Turan, Bengisu Benligül, Ebru Melek Children (Basel) Article The accurate prediction of the prognosis for critically ill children is crucial, with the Pediatric Index of Mortality (PIM) and Pediatric Risk of Mortality (PRISM) being extensively utilized for this purpose. Albumin, C-reactive protein (CRP), and lactate levels, which are indicative of inflammation and circulatory status in critically ill children, have not been incorporated into existing scoring systems. This retrospective cohort study evaluated the association between biological markers and the clinical outcomes in children with critical illnesses. PRISM-4 and PIM-3 death probability (DP), albumin, lactate, CRP, and CRP/albumin ratio were recorded upon admission. The accuracy of the indexes in predicting mortality were assessed by calculating the area under the curve (AUC). There were 942 patients included and the 28-day mortality rate was 7.9%. The AUC for PRISM-4, PIM-3, CRP, CRP/albumin ratio, albumin, and lactate were 0.923, 0.896, 0.798, 0.795, 0.751, 0.728, respectively. The findings in the subgroup analysis of septic patients were similar to those found in the overall population. Although CRP, CRP/albumin ratio, albumin, and lactate levels are all linked to mortality in children, CRP and the CRP/albumin ratio have lower predictive values than albumin and lactate. Incorporation of albumin and lactate into scoring systems will improve predictability. MDPI 2023-10-26 /pmc/articles/PMC10670452/ /pubmed/38002822 http://dx.doi.org/10.3390/children10111731 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arslan, Gazi
Besci, Tolga
Özdemir, Göktuğ
Evren, Gültaç
Ilgaz Tüzen, Hande
Prencuva, Pınar
Turan, Bengisu
Benligül, Ebru Melek
Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children
title Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children
title_full Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children
title_fullStr Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children
title_full_unstemmed Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children
title_short Predictive Value of PRISM-4, PIM-3, CRP, Albumin, CRP/Albumin Ratio and Lactate in Critically Ill Children
title_sort predictive value of prism-4, pim-3, crp, albumin, crp/albumin ratio and lactate in critically ill children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670452/
https://www.ncbi.nlm.nih.gov/pubmed/38002822
http://dx.doi.org/10.3390/children10111731
work_keys_str_mv AT arslangazi predictivevalueofprism4pim3crpalbumincrpalbuminratioandlactateincriticallyillchildren
AT bescitolga predictivevalueofprism4pim3crpalbumincrpalbuminratioandlactateincriticallyillchildren
AT ozdemirgoktug predictivevalueofprism4pim3crpalbumincrpalbuminratioandlactateincriticallyillchildren
AT evrengultac predictivevalueofprism4pim3crpalbumincrpalbuminratioandlactateincriticallyillchildren
AT ilgaztuzenhande predictivevalueofprism4pim3crpalbumincrpalbuminratioandlactateincriticallyillchildren
AT prencuvapınar predictivevalueofprism4pim3crpalbumincrpalbuminratioandlactateincriticallyillchildren
AT turanbengisu predictivevalueofprism4pim3crpalbumincrpalbuminratioandlactateincriticallyillchildren
AT benligulebrumelek predictivevalueofprism4pim3crpalbumincrpalbuminratioandlactateincriticallyillchildren