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Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control

Radiotherapy (RT) and electrochemotherapy (ECT) are established local treatments for cancer. While effective, both therapies have limitations, especially in treating bulky and poorly oxygenated tumors. ECT has emerged as a promising palliative treatment, raising interest in exploring its combination...

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Autores principales: Ferioli, Martina, Perrone, Anna M., Buwenge, Milly, Arcelli, Alessandra, Vadala’, Maria, Fionda, Bruno, Malato, Maria C., De Iaco, Pierandrea, Zamagni, Claudio, Cammelli, Silvia, Tagliaferri, Luca, Morganti, Alessio G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670517/
https://www.ncbi.nlm.nih.gov/pubmed/37999139
http://dx.doi.org/10.3390/curroncol30110719
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author Ferioli, Martina
Perrone, Anna M.
Buwenge, Milly
Arcelli, Alessandra
Vadala’, Maria
Fionda, Bruno
Malato, Maria C.
De Iaco, Pierandrea
Zamagni, Claudio
Cammelli, Silvia
Tagliaferri, Luca
Morganti, Alessio G.
author_facet Ferioli, Martina
Perrone, Anna M.
Buwenge, Milly
Arcelli, Alessandra
Vadala’, Maria
Fionda, Bruno
Malato, Maria C.
De Iaco, Pierandrea
Zamagni, Claudio
Cammelli, Silvia
Tagliaferri, Luca
Morganti, Alessio G.
author_sort Ferioli, Martina
collection PubMed
description Radiotherapy (RT) and electrochemotherapy (ECT) are established local treatments for cancer. While effective, both therapies have limitations, especially in treating bulky and poorly oxygenated tumors. ECT has emerged as a promising palliative treatment, raising interest in exploring its combination with RT to enhance tumor response. However, the potential benefits and challenges of combining these treatments remain unclear. A systematic review was conducted following PRISMA guidelines. PubMed, Scopus, and Cochrane libraries were searched. Studies were screened and selected based on predefined inclusion and exclusion criteria. Ten studies were included, comprising in vitro and in vivo experiments. Different tumor types were treated with ECT alone or in combination with RT. ECT plus RT demonstrated superior tumor response compared to that under single therapies or other combinations, regardless of the cytotoxic agent and RT dose. However, no study demonstrated a clear superadditive effect in cell survival curves, suggesting inconclusive evidence of specific ECT-induced radiosensitization. Toxicity data were limited. In conclusion, the combination of ECT and RT consistently improved tumor response compared to that with individual therapies, supporting the potential benefit of their combination. However, evidence for a specific ECT-induced radiosensitization effect is currently lacking. Additional investigations are necessary to elucidate the potential benefits of this combination therapy.
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spelling pubmed-106705172023-11-13 Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control Ferioli, Martina Perrone, Anna M. Buwenge, Milly Arcelli, Alessandra Vadala’, Maria Fionda, Bruno Malato, Maria C. De Iaco, Pierandrea Zamagni, Claudio Cammelli, Silvia Tagliaferri, Luca Morganti, Alessio G. Curr Oncol Systematic Review Radiotherapy (RT) and electrochemotherapy (ECT) are established local treatments for cancer. While effective, both therapies have limitations, especially in treating bulky and poorly oxygenated tumors. ECT has emerged as a promising palliative treatment, raising interest in exploring its combination with RT to enhance tumor response. However, the potential benefits and challenges of combining these treatments remain unclear. A systematic review was conducted following PRISMA guidelines. PubMed, Scopus, and Cochrane libraries were searched. Studies were screened and selected based on predefined inclusion and exclusion criteria. Ten studies were included, comprising in vitro and in vivo experiments. Different tumor types were treated with ECT alone or in combination with RT. ECT plus RT demonstrated superior tumor response compared to that under single therapies or other combinations, regardless of the cytotoxic agent and RT dose. However, no study demonstrated a clear superadditive effect in cell survival curves, suggesting inconclusive evidence of specific ECT-induced radiosensitization. Toxicity data were limited. In conclusion, the combination of ECT and RT consistently improved tumor response compared to that with individual therapies, supporting the potential benefit of their combination. However, evidence for a specific ECT-induced radiosensitization effect is currently lacking. Additional investigations are necessary to elucidate the potential benefits of this combination therapy. MDPI 2023-11-13 /pmc/articles/PMC10670517/ /pubmed/37999139 http://dx.doi.org/10.3390/curroncol30110719 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Ferioli, Martina
Perrone, Anna M.
Buwenge, Milly
Arcelli, Alessandra
Vadala’, Maria
Fionda, Bruno
Malato, Maria C.
De Iaco, Pierandrea
Zamagni, Claudio
Cammelli, Silvia
Tagliaferri, Luca
Morganti, Alessio G.
Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control
title Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control
title_full Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control
title_fullStr Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control
title_full_unstemmed Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control
title_short Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control
title_sort combination of electrochemotherapy with radiotherapy: a comprehensive, systematic, prisma-compliant review of efficacy and potential radiosensitizing effects in tumor control
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670517/
https://www.ncbi.nlm.nih.gov/pubmed/37999139
http://dx.doi.org/10.3390/curroncol30110719
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