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Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors

Circulating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence in peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression and treatment response. This narrative literatur...

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Autores principales: Capuozzo, Maurizio, Ferrara, Francesco, Santorsola, Mariachiara, Zovi, Andrea, Ottaiano, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670669/
https://www.ncbi.nlm.nih.gov/pubmed/37998325
http://dx.doi.org/10.3390/cells12222590
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author Capuozzo, Maurizio
Ferrara, Francesco
Santorsola, Mariachiara
Zovi, Andrea
Ottaiano, Alessandro
author_facet Capuozzo, Maurizio
Ferrara, Francesco
Santorsola, Mariachiara
Zovi, Andrea
Ottaiano, Alessandro
author_sort Capuozzo, Maurizio
collection PubMed
description Circulating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence in peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression and treatment response. This narrative literature review synthesizes the current state of knowledge surrounding the multifaceted role of CTCs in predicting clinical outcomes and informing prognosis across a spectrum of solid tumor malignancies. This review delves into the evolving landscape of CTC-based research, emphasizing their potential as early indicators of disease recurrence, metastatic potential, and therapeutic resistance. Moreover, we have underscored the dynamic nature of CTCs and their implications for personalized medicine. A descriptive and critical analysis of CTC detection methodologies, their clinical relevance, and their associated challenges is also presented, with a focus on recent advancements and emerging technologies. Furthermore, we examine the integration of CTC-based liquid biopsies into clinical practice, highlighting their role in guiding treatment decisions, monitoring treatment efficacy, and facilitating precision oncology. This review highlights the transformative impact of CTCs as predictive and prognostic biomarkers in the management of solid tumors by promoting a deeper understanding of the clinical relevance of CTCs and their role in advancing the field of oncology.
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spelling pubmed-106706692023-11-08 Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors Capuozzo, Maurizio Ferrara, Francesco Santorsola, Mariachiara Zovi, Andrea Ottaiano, Alessandro Cells Review Circulating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence in peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression and treatment response. This narrative literature review synthesizes the current state of knowledge surrounding the multifaceted role of CTCs in predicting clinical outcomes and informing prognosis across a spectrum of solid tumor malignancies. This review delves into the evolving landscape of CTC-based research, emphasizing their potential as early indicators of disease recurrence, metastatic potential, and therapeutic resistance. Moreover, we have underscored the dynamic nature of CTCs and their implications for personalized medicine. A descriptive and critical analysis of CTC detection methodologies, their clinical relevance, and their associated challenges is also presented, with a focus on recent advancements and emerging technologies. Furthermore, we examine the integration of CTC-based liquid biopsies into clinical practice, highlighting their role in guiding treatment decisions, monitoring treatment efficacy, and facilitating precision oncology. This review highlights the transformative impact of CTCs as predictive and prognostic biomarkers in the management of solid tumors by promoting a deeper understanding of the clinical relevance of CTCs and their role in advancing the field of oncology. MDPI 2023-11-08 /pmc/articles/PMC10670669/ /pubmed/37998325 http://dx.doi.org/10.3390/cells12222590 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Capuozzo, Maurizio
Ferrara, Francesco
Santorsola, Mariachiara
Zovi, Andrea
Ottaiano, Alessandro
Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors
title Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors
title_full Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors
title_fullStr Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors
title_full_unstemmed Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors
title_short Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors
title_sort circulating tumor cells as predictive and prognostic biomarkers in solid tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670669/
https://www.ncbi.nlm.nih.gov/pubmed/37998325
http://dx.doi.org/10.3390/cells12222590
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