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Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors
Circulating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence in peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression and treatment response. This narrative literatur...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670669/ https://www.ncbi.nlm.nih.gov/pubmed/37998325 http://dx.doi.org/10.3390/cells12222590 |
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author | Capuozzo, Maurizio Ferrara, Francesco Santorsola, Mariachiara Zovi, Andrea Ottaiano, Alessandro |
author_facet | Capuozzo, Maurizio Ferrara, Francesco Santorsola, Mariachiara Zovi, Andrea Ottaiano, Alessandro |
author_sort | Capuozzo, Maurizio |
collection | PubMed |
description | Circulating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence in peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression and treatment response. This narrative literature review synthesizes the current state of knowledge surrounding the multifaceted role of CTCs in predicting clinical outcomes and informing prognosis across a spectrum of solid tumor malignancies. This review delves into the evolving landscape of CTC-based research, emphasizing their potential as early indicators of disease recurrence, metastatic potential, and therapeutic resistance. Moreover, we have underscored the dynamic nature of CTCs and their implications for personalized medicine. A descriptive and critical analysis of CTC detection methodologies, their clinical relevance, and their associated challenges is also presented, with a focus on recent advancements and emerging technologies. Furthermore, we examine the integration of CTC-based liquid biopsies into clinical practice, highlighting their role in guiding treatment decisions, monitoring treatment efficacy, and facilitating precision oncology. This review highlights the transformative impact of CTCs as predictive and prognostic biomarkers in the management of solid tumors by promoting a deeper understanding of the clinical relevance of CTCs and their role in advancing the field of oncology. |
format | Online Article Text |
id | pubmed-10670669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106706692023-11-08 Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors Capuozzo, Maurizio Ferrara, Francesco Santorsola, Mariachiara Zovi, Andrea Ottaiano, Alessandro Cells Review Circulating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence in peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression and treatment response. This narrative literature review synthesizes the current state of knowledge surrounding the multifaceted role of CTCs in predicting clinical outcomes and informing prognosis across a spectrum of solid tumor malignancies. This review delves into the evolving landscape of CTC-based research, emphasizing their potential as early indicators of disease recurrence, metastatic potential, and therapeutic resistance. Moreover, we have underscored the dynamic nature of CTCs and their implications for personalized medicine. A descriptive and critical analysis of CTC detection methodologies, their clinical relevance, and their associated challenges is also presented, with a focus on recent advancements and emerging technologies. Furthermore, we examine the integration of CTC-based liquid biopsies into clinical practice, highlighting their role in guiding treatment decisions, monitoring treatment efficacy, and facilitating precision oncology. This review highlights the transformative impact of CTCs as predictive and prognostic biomarkers in the management of solid tumors by promoting a deeper understanding of the clinical relevance of CTCs and their role in advancing the field of oncology. MDPI 2023-11-08 /pmc/articles/PMC10670669/ /pubmed/37998325 http://dx.doi.org/10.3390/cells12222590 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Capuozzo, Maurizio Ferrara, Francesco Santorsola, Mariachiara Zovi, Andrea Ottaiano, Alessandro Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
title | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
title_full | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
title_fullStr | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
title_full_unstemmed | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
title_short | Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors |
title_sort | circulating tumor cells as predictive and prognostic biomarkers in solid tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670669/ https://www.ncbi.nlm.nih.gov/pubmed/37998325 http://dx.doi.org/10.3390/cells12222590 |
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