Cargando…
The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial
Global rates of adolescent obesity have led the World Health Organization to consider the disease a pandemic that needs focus. In search of new anti-obesity agents, Crocus sativus, popularly known as saffron, is a nutraceutical agent, praised for its beneficial effects. The study aimed to investigat...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670718/ https://www.ncbi.nlm.nih.gov/pubmed/38002905 http://dx.doi.org/10.3390/children10111814 |
_version_ | 1785149343413567488 |
---|---|
author | Kotanidou, Eleni P. Tsinopoulou, Vasiliki Rengina Giza, Styliani Ntouma, Stergianna Angeli, Chrysanthi Chatziandreou, Michail Tsopelas, Konstantinos Tseti, Ioulia Galli-Tsinopoulou, Assimina |
author_facet | Kotanidou, Eleni P. Tsinopoulou, Vasiliki Rengina Giza, Styliani Ntouma, Stergianna Angeli, Chrysanthi Chatziandreou, Michail Tsopelas, Konstantinos Tseti, Ioulia Galli-Tsinopoulou, Assimina |
author_sort | Kotanidou, Eleni P. |
collection | PubMed |
description | Global rates of adolescent obesity have led the World Health Organization to consider the disease a pandemic that needs focus. In search of new anti-obesity agents, Crocus sativus, popularly known as saffron, is a nutraceutical agent, praised for its beneficial effects. The study aimed to investigate the possible effect of Kozanis saffron administration on weight management of obese prediabetic adolescents. Seventy-four obese prediabetic adolescents participated in a double-blind placebo-controlled trial of three arms, randomly assigned to receive either Kozanis saffron (n = 25, 60 mg/day), metformin (n = 25, 1000 mg/day) or a placebo (n = 24), for twelve weeks. Anthropometry, glycemic markers and lipid profiles were investigated at baseline and post-intervention. Saffron supplementation significantly reduced the weight z-score, BMI, BMI z-score and waist circumference (WC) of obese adolescents; however, this reduction was less significant compared to the effect of metformin. Metformin administration offered a significantly more profound improvement in anthropometry compared to saffron administration. Saffron administration also provided significant improvements in weight, weight z-scores, BMI values, BMI z-scores and WCs compared to the placebo. Saffron supplementation failed to change any glycemic marker, but provided a significant reduction in fasting triglyceride levels and also a significant increase in fasting HDL levels. Saffron Kozanis constitutes a promising nutraceutical option for adolescents and children with obesity and prediabetes in need of weight management. |
format | Online Article Text |
id | pubmed-10670718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106707182023-11-15 The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial Kotanidou, Eleni P. Tsinopoulou, Vasiliki Rengina Giza, Styliani Ntouma, Stergianna Angeli, Chrysanthi Chatziandreou, Michail Tsopelas, Konstantinos Tseti, Ioulia Galli-Tsinopoulou, Assimina Children (Basel) Article Global rates of adolescent obesity have led the World Health Organization to consider the disease a pandemic that needs focus. In search of new anti-obesity agents, Crocus sativus, popularly known as saffron, is a nutraceutical agent, praised for its beneficial effects. The study aimed to investigate the possible effect of Kozanis saffron administration on weight management of obese prediabetic adolescents. Seventy-four obese prediabetic adolescents participated in a double-blind placebo-controlled trial of three arms, randomly assigned to receive either Kozanis saffron (n = 25, 60 mg/day), metformin (n = 25, 1000 mg/day) or a placebo (n = 24), for twelve weeks. Anthropometry, glycemic markers and lipid profiles were investigated at baseline and post-intervention. Saffron supplementation significantly reduced the weight z-score, BMI, BMI z-score and waist circumference (WC) of obese adolescents; however, this reduction was less significant compared to the effect of metformin. Metformin administration offered a significantly more profound improvement in anthropometry compared to saffron administration. Saffron administration also provided significant improvements in weight, weight z-scores, BMI values, BMI z-scores and WCs compared to the placebo. Saffron supplementation failed to change any glycemic marker, but provided a significant reduction in fasting triglyceride levels and also a significant increase in fasting HDL levels. Saffron Kozanis constitutes a promising nutraceutical option for adolescents and children with obesity and prediabetes in need of weight management. MDPI 2023-11-15 /pmc/articles/PMC10670718/ /pubmed/38002905 http://dx.doi.org/10.3390/children10111814 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kotanidou, Eleni P. Tsinopoulou, Vasiliki Rengina Giza, Styliani Ntouma, Stergianna Angeli, Chrysanthi Chatziandreou, Michail Tsopelas, Konstantinos Tseti, Ioulia Galli-Tsinopoulou, Assimina The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial |
title | The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial |
title_full | The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial |
title_fullStr | The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial |
title_full_unstemmed | The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial |
title_short | The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial |
title_sort | effect of saffron kozanis (crocus sativus l.) supplementation on weight management, glycemic markers and lipid profile in adolescents with obesity: a double-blinded randomized placebo-controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670718/ https://www.ncbi.nlm.nih.gov/pubmed/38002905 http://dx.doi.org/10.3390/children10111814 |
work_keys_str_mv | AT kotanidouelenip theeffectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT tsinopoulouvasilikirengina theeffectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT gizastyliani theeffectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT ntoumastergianna theeffectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT angelichrysanthi theeffectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT chatziandreoumichail theeffectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT tsopelaskonstantinos theeffectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT tsetiioulia theeffectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT gallitsinopoulouassimina theeffectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT kotanidouelenip effectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT tsinopoulouvasilikirengina effectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT gizastyliani effectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT ntoumastergianna effectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT angelichrysanthi effectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT chatziandreoumichail effectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT tsopelaskonstantinos effectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT tsetiioulia effectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial AT gallitsinopoulouassimina effectofsaffronkozaniscrocussativuslsupplementationonweightmanagementglycemicmarkersandlipidprofileinadolescentswithobesityadoubleblindedrandomizedplacebocontrolledtrial |