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The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial

Global rates of adolescent obesity have led the World Health Organization to consider the disease a pandemic that needs focus. In search of new anti-obesity agents, Crocus sativus, popularly known as saffron, is a nutraceutical agent, praised for its beneficial effects. The study aimed to investigat...

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Autores principales: Kotanidou, Eleni P., Tsinopoulou, Vasiliki Rengina, Giza, Styliani, Ntouma, Stergianna, Angeli, Chrysanthi, Chatziandreou, Michail, Tsopelas, Konstantinos, Tseti, Ioulia, Galli-Tsinopoulou, Assimina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670718/
https://www.ncbi.nlm.nih.gov/pubmed/38002905
http://dx.doi.org/10.3390/children10111814
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author Kotanidou, Eleni P.
Tsinopoulou, Vasiliki Rengina
Giza, Styliani
Ntouma, Stergianna
Angeli, Chrysanthi
Chatziandreou, Michail
Tsopelas, Konstantinos
Tseti, Ioulia
Galli-Tsinopoulou, Assimina
author_facet Kotanidou, Eleni P.
Tsinopoulou, Vasiliki Rengina
Giza, Styliani
Ntouma, Stergianna
Angeli, Chrysanthi
Chatziandreou, Michail
Tsopelas, Konstantinos
Tseti, Ioulia
Galli-Tsinopoulou, Assimina
author_sort Kotanidou, Eleni P.
collection PubMed
description Global rates of adolescent obesity have led the World Health Organization to consider the disease a pandemic that needs focus. In search of new anti-obesity agents, Crocus sativus, popularly known as saffron, is a nutraceutical agent, praised for its beneficial effects. The study aimed to investigate the possible effect of Kozanis saffron administration on weight management of obese prediabetic adolescents. Seventy-four obese prediabetic adolescents participated in a double-blind placebo-controlled trial of three arms, randomly assigned to receive either Kozanis saffron (n = 25, 60 mg/day), metformin (n = 25, 1000 mg/day) or a placebo (n = 24), for twelve weeks. Anthropometry, glycemic markers and lipid profiles were investigated at baseline and post-intervention. Saffron supplementation significantly reduced the weight z-score, BMI, BMI z-score and waist circumference (WC) of obese adolescents; however, this reduction was less significant compared to the effect of metformin. Metformin administration offered a significantly more profound improvement in anthropometry compared to saffron administration. Saffron administration also provided significant improvements in weight, weight z-scores, BMI values, BMI z-scores and WCs compared to the placebo. Saffron supplementation failed to change any glycemic marker, but provided a significant reduction in fasting triglyceride levels and also a significant increase in fasting HDL levels. Saffron Kozanis constitutes a promising nutraceutical option for adolescents and children with obesity and prediabetes in need of weight management.
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spelling pubmed-106707182023-11-15 The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial Kotanidou, Eleni P. Tsinopoulou, Vasiliki Rengina Giza, Styliani Ntouma, Stergianna Angeli, Chrysanthi Chatziandreou, Michail Tsopelas, Konstantinos Tseti, Ioulia Galli-Tsinopoulou, Assimina Children (Basel) Article Global rates of adolescent obesity have led the World Health Organization to consider the disease a pandemic that needs focus. In search of new anti-obesity agents, Crocus sativus, popularly known as saffron, is a nutraceutical agent, praised for its beneficial effects. The study aimed to investigate the possible effect of Kozanis saffron administration on weight management of obese prediabetic adolescents. Seventy-four obese prediabetic adolescents participated in a double-blind placebo-controlled trial of three arms, randomly assigned to receive either Kozanis saffron (n = 25, 60 mg/day), metformin (n = 25, 1000 mg/day) or a placebo (n = 24), for twelve weeks. Anthropometry, glycemic markers and lipid profiles were investigated at baseline and post-intervention. Saffron supplementation significantly reduced the weight z-score, BMI, BMI z-score and waist circumference (WC) of obese adolescents; however, this reduction was less significant compared to the effect of metformin. Metformin administration offered a significantly more profound improvement in anthropometry compared to saffron administration. Saffron administration also provided significant improvements in weight, weight z-scores, BMI values, BMI z-scores and WCs compared to the placebo. Saffron supplementation failed to change any glycemic marker, but provided a significant reduction in fasting triglyceride levels and also a significant increase in fasting HDL levels. Saffron Kozanis constitutes a promising nutraceutical option for adolescents and children with obesity and prediabetes in need of weight management. MDPI 2023-11-15 /pmc/articles/PMC10670718/ /pubmed/38002905 http://dx.doi.org/10.3390/children10111814 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kotanidou, Eleni P.
Tsinopoulou, Vasiliki Rengina
Giza, Styliani
Ntouma, Stergianna
Angeli, Chrysanthi
Chatziandreou, Michail
Tsopelas, Konstantinos
Tseti, Ioulia
Galli-Tsinopoulou, Assimina
The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial
title The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial
title_full The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial
title_fullStr The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial
title_full_unstemmed The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial
title_short The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial
title_sort effect of saffron kozanis (crocus sativus l.) supplementation on weight management, glycemic markers and lipid profile in adolescents with obesity: a double-blinded randomized placebo-controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670718/
https://www.ncbi.nlm.nih.gov/pubmed/38002905
http://dx.doi.org/10.3390/children10111814
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