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Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations

SIMPLE SUMMARY: Acquired resistance of gastrointestinal stromal tumors (GISTs) to imatinib mesylate (IM) is one of the most critical challenges in GIST therapy. Here we show that a long-term culture of GIST T-1 cells with IM induces clonal heterogeneity resulting in the appearance of cancer cells ex...

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Detalles Bibliográficos
Autores principales:	Boichuk, Sergei, Dunaev, Pavel, Skripova, Vera, Galembikova, Aigul, Bikinieva, Firyuza, Shagimardanova, Elena, Gazizova, Guzel, Deviatiiarov, Ruslan, Valeeva, Elena, Mikheeva, Ekaterina, Vasilyeva, Maria, Kopnin, Pavel, Strelnikov, Vladimir, Kiyamova, Ramziya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670741/ https://www.ncbi.nlm.nih.gov/pubmed/38001614 http://dx.doi.org/10.3390/cancers15225354

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