HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature

Drug-induced liver injury (DILI) is one of the serious adverse drug reactions (ADRs), which belongs to immune-mediated adverse drug reactions (IM-ADRs). As an essential health drug, albendazole has rarely been reported to cause serious liver damage. A young man in his 30 s developed severe jaundice,...

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Autores principales: Liao, Jin-Mao, Zhan, Yan, Zhang, Zheng, Cui, Jia-Jia, Yin, Ji-Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670799/
https://www.ncbi.nlm.nih.gov/pubmed/38027017
http://dx.doi.org/10.3389/fphar.2023.1288068
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author Liao, Jin-Mao
Zhan, Yan
Zhang, Zheng
Cui, Jia-Jia
Yin, Ji-Ye
author_facet Liao, Jin-Mao
Zhan, Yan
Zhang, Zheng
Cui, Jia-Jia
Yin, Ji-Ye
author_sort Liao, Jin-Mao
collection PubMed
description Drug-induced liver injury (DILI) is one of the serious adverse drug reactions (ADRs), which belongs to immune-mediated adverse drug reactions (IM-ADRs). As an essential health drug, albendazole has rarely been reported to cause serious liver damage. A young man in his 30 s developed severe jaundice, abnormal transaminases, and poor blood coagulation mechanism after taking albendazole, and eventually developed into severe liver failure. The patient was found heterozygous of HLA-B*15:02 and HLA-B*13:01 through HLA-targeted sequencing, which may have a pathogenic role in the disease. This case report summarizes his presentation, treatment, and prognosis. A useful summary of the diagnosis and associated genetic variant information is provided.
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spelling pubmed-106707992023-11-09 HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature Liao, Jin-Mao Zhan, Yan Zhang, Zheng Cui, Jia-Jia Yin, Ji-Ye Front Pharmacol Pharmacology Drug-induced liver injury (DILI) is one of the serious adverse drug reactions (ADRs), which belongs to immune-mediated adverse drug reactions (IM-ADRs). As an essential health drug, albendazole has rarely been reported to cause serious liver damage. A young man in his 30 s developed severe jaundice, abnormal transaminases, and poor blood coagulation mechanism after taking albendazole, and eventually developed into severe liver failure. The patient was found heterozygous of HLA-B*15:02 and HLA-B*13:01 through HLA-targeted sequencing, which may have a pathogenic role in the disease. This case report summarizes his presentation, treatment, and prognosis. A useful summary of the diagnosis and associated genetic variant information is provided. Frontiers Media S.A. 2023-11-09 /pmc/articles/PMC10670799/ /pubmed/38027017 http://dx.doi.org/10.3389/fphar.2023.1288068 Text en Copyright © 2023 Liao, Zhan, Zhang, Cui and Yin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liao, Jin-Mao
Zhan, Yan
Zhang, Zheng
Cui, Jia-Jia
Yin, Ji-Ye
HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature
title HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature
title_full HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature
title_fullStr HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature
title_full_unstemmed HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature
title_short HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature
title_sort hla-targeted sequencing reveals the pathogenic role of hla-b*15:02/hla-b*13:01 in albendazole-induced liver failure: a case report and a review of the literature
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670799/
https://www.ncbi.nlm.nih.gov/pubmed/38027017
http://dx.doi.org/10.3389/fphar.2023.1288068
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