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Effect of Breast Screening Regimen on Breast Cancer Outcomes: A Modeling Study

Guidelines vary for the age at which to begin breast cancer screening and the interval between examinations. A validated computer model was used to compare estimated outcomes between various screening regimens. The OncoSim-Breast microsimulation model (Canadian Partnership Against Cancer) was used t...

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Autores principales: Yaffe, Martin J., Mainprize, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670884/
https://www.ncbi.nlm.nih.gov/pubmed/37999106
http://dx.doi.org/10.3390/curroncol30110686
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author Yaffe, Martin J.
Mainprize, James G.
author_facet Yaffe, Martin J.
Mainprize, James G.
author_sort Yaffe, Martin J.
collection PubMed
description Guidelines vary for the age at which to begin breast cancer screening and the interval between examinations. A validated computer model was used to compare estimated outcomes between various screening regimens. The OncoSim-Breast microsimulation model (Canadian Partnership Against Cancer) was used to simulate a cohort of 1.53 million Canadian women born in 1975. The effect of screening regimen on absolute breast cancer mortality rates, stage at diagnosis, number needed to be screened to avert a breast cancer death or save a life year, abnormal recall rates and negative biopsy rates was examined for unscreened women or those entering screening at age 40 or 50 and screened annually or biennially to age 74. Compared to no screening, absolute mortality reduction was 4.6 (biennial 50–74), 5.9 (biennial 40–74) and 7.9 (annual 40–74) fewer deaths per 1000 women. The absolute rate of diagnosis of advanced cancers (Stage 2, 3 and 4) falls in favor of earlier stages as the number of lifetime screens increases. Annual screening beginning at age 40 until age 74 would provide an additional reduction of 2 and 3.3 breast cancer deaths per 1000 women compared to biennial screening beginning at ages 40 and 50, respectively. There is a corresponding drop in the absolute number of Stage 2, 3 and 4 cancers diagnosed.
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spelling pubmed-106708842023-10-25 Effect of Breast Screening Regimen on Breast Cancer Outcomes: A Modeling Study Yaffe, Martin J. Mainprize, James G. Curr Oncol Article Guidelines vary for the age at which to begin breast cancer screening and the interval between examinations. A validated computer model was used to compare estimated outcomes between various screening regimens. The OncoSim-Breast microsimulation model (Canadian Partnership Against Cancer) was used to simulate a cohort of 1.53 million Canadian women born in 1975. The effect of screening regimen on absolute breast cancer mortality rates, stage at diagnosis, number needed to be screened to avert a breast cancer death or save a life year, abnormal recall rates and negative biopsy rates was examined for unscreened women or those entering screening at age 40 or 50 and screened annually or biennially to age 74. Compared to no screening, absolute mortality reduction was 4.6 (biennial 50–74), 5.9 (biennial 40–74) and 7.9 (annual 40–74) fewer deaths per 1000 women. The absolute rate of diagnosis of advanced cancers (Stage 2, 3 and 4) falls in favor of earlier stages as the number of lifetime screens increases. Annual screening beginning at age 40 until age 74 would provide an additional reduction of 2 and 3.3 breast cancer deaths per 1000 women compared to biennial screening beginning at ages 40 and 50, respectively. There is a corresponding drop in the absolute number of Stage 2, 3 and 4 cancers diagnosed. MDPI 2023-10-25 /pmc/articles/PMC10670884/ /pubmed/37999106 http://dx.doi.org/10.3390/curroncol30110686 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yaffe, Martin J.
Mainprize, James G.
Effect of Breast Screening Regimen on Breast Cancer Outcomes: A Modeling Study
title Effect of Breast Screening Regimen on Breast Cancer Outcomes: A Modeling Study
title_full Effect of Breast Screening Regimen on Breast Cancer Outcomes: A Modeling Study
title_fullStr Effect of Breast Screening Regimen on Breast Cancer Outcomes: A Modeling Study
title_full_unstemmed Effect of Breast Screening Regimen on Breast Cancer Outcomes: A Modeling Study
title_short Effect of Breast Screening Regimen on Breast Cancer Outcomes: A Modeling Study
title_sort effect of breast screening regimen on breast cancer outcomes: a modeling study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670884/
https://www.ncbi.nlm.nih.gov/pubmed/37999106
http://dx.doi.org/10.3390/curroncol30110686
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