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Nanoparticles Based on Silver Chloride and Bambusuril[6] for the Fine-Tuning of Biological Activity

The prevalence of numerous infectious diseases has emerged as a grave concern within the realm of healthcare. Currently, the issue of antibiotic resistance is compelling scientists to explore novel treatment approaches. To combat these infectious diseases, various treatment methods have been develop...

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Detalles Bibliográficos
Autores principales: Turebayeva, Pana, Luchsheva, Venera, Fedorishin, Dmitriy, Yerkassov, Rakhmetulla, Bakibaev, Abdigali, Bolysbekova, Saltanat, Tugambayeva, Tokzhan, Sergazina, Samal, Nurmukhanbetova, Nurgul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670921/
https://www.ncbi.nlm.nih.gov/pubmed/38003315
http://dx.doi.org/10.3390/ijms242216126
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author Turebayeva, Pana
Luchsheva, Venera
Fedorishin, Dmitriy
Yerkassov, Rakhmetulla
Bakibaev, Abdigali
Bolysbekova, Saltanat
Tugambayeva, Tokzhan
Sergazina, Samal
Nurmukhanbetova, Nurgul
author_facet Turebayeva, Pana
Luchsheva, Venera
Fedorishin, Dmitriy
Yerkassov, Rakhmetulla
Bakibaev, Abdigali
Bolysbekova, Saltanat
Tugambayeva, Tokzhan
Sergazina, Samal
Nurmukhanbetova, Nurgul
author_sort Turebayeva, Pana
collection PubMed
description The prevalence of numerous infectious diseases has emerged as a grave concern within the realm of healthcare. Currently, the issue of antibiotic resistance is compelling scientists to explore novel treatment approaches. To combat these infectious diseases, various treatment methods have been developed, harnessing cutting-edge disinfecting nanomaterials. Among the range of metallic nanoparticles employed in medicine, silver nanoparticles (AgNPs) stand out as both highly popular and well-suited for the task. They find extensive utility in cancer diagnosis and therapies and as effective antibacterial agents. The interaction between silver and bacterial cells induces significant structural and morphological alterations, ultimately leading to cell demise. In this study, nanoparticles based on silver and bambusuril[6] (BU[6]) were developed for the first time. These NPs can be used for different biomedical purposes. A simple, single-step, and effective synthesis method was employed to produce bambusuril[6]-protected silver chloride nanoparticles (BU[6]-Ag/AgCl NPs) through the complexation of BU[6] with silver nitrate. The NPs were characterized using X-ray phase analysis (XPS), infrared spectroscopy (IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). When the SEM images were examined, it was seen that the synthesized BU[6]-Ag/AgCl NPs were distributed with homogeneous sizes, and the synthesized NPs were mostly spherical and cubic. The EDS spectra of BU[6]-Ag/AgCl NPs demonstrated the presence of Ag, Cl, and all expected elements. BU[6]-Ag/AgCl NPs showed high antibacterial activity against both E. coli and S. aureus bacteria.
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spelling pubmed-106709212023-11-09 Nanoparticles Based on Silver Chloride and Bambusuril[6] for the Fine-Tuning of Biological Activity Turebayeva, Pana Luchsheva, Venera Fedorishin, Dmitriy Yerkassov, Rakhmetulla Bakibaev, Abdigali Bolysbekova, Saltanat Tugambayeva, Tokzhan Sergazina, Samal Nurmukhanbetova, Nurgul Int J Mol Sci Article The prevalence of numerous infectious diseases has emerged as a grave concern within the realm of healthcare. Currently, the issue of antibiotic resistance is compelling scientists to explore novel treatment approaches. To combat these infectious diseases, various treatment methods have been developed, harnessing cutting-edge disinfecting nanomaterials. Among the range of metallic nanoparticles employed in medicine, silver nanoparticles (AgNPs) stand out as both highly popular and well-suited for the task. They find extensive utility in cancer diagnosis and therapies and as effective antibacterial agents. The interaction between silver and bacterial cells induces significant structural and morphological alterations, ultimately leading to cell demise. In this study, nanoparticles based on silver and bambusuril[6] (BU[6]) were developed for the first time. These NPs can be used for different biomedical purposes. A simple, single-step, and effective synthesis method was employed to produce bambusuril[6]-protected silver chloride nanoparticles (BU[6]-Ag/AgCl NPs) through the complexation of BU[6] with silver nitrate. The NPs were characterized using X-ray phase analysis (XPS), infrared spectroscopy (IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). When the SEM images were examined, it was seen that the synthesized BU[6]-Ag/AgCl NPs were distributed with homogeneous sizes, and the synthesized NPs were mostly spherical and cubic. The EDS spectra of BU[6]-Ag/AgCl NPs demonstrated the presence of Ag, Cl, and all expected elements. BU[6]-Ag/AgCl NPs showed high antibacterial activity against both E. coli and S. aureus bacteria. MDPI 2023-11-09 /pmc/articles/PMC10670921/ /pubmed/38003315 http://dx.doi.org/10.3390/ijms242216126 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Turebayeva, Pana
Luchsheva, Venera
Fedorishin, Dmitriy
Yerkassov, Rakhmetulla
Bakibaev, Abdigali
Bolysbekova, Saltanat
Tugambayeva, Tokzhan
Sergazina, Samal
Nurmukhanbetova, Nurgul
Nanoparticles Based on Silver Chloride and Bambusuril[6] for the Fine-Tuning of Biological Activity
title Nanoparticles Based on Silver Chloride and Bambusuril[6] for the Fine-Tuning of Biological Activity
title_full Nanoparticles Based on Silver Chloride and Bambusuril[6] for the Fine-Tuning of Biological Activity
title_fullStr Nanoparticles Based on Silver Chloride and Bambusuril[6] for the Fine-Tuning of Biological Activity
title_full_unstemmed Nanoparticles Based on Silver Chloride and Bambusuril[6] for the Fine-Tuning of Biological Activity
title_short Nanoparticles Based on Silver Chloride and Bambusuril[6] for the Fine-Tuning of Biological Activity
title_sort nanoparticles based on silver chloride and bambusuril[6] for the fine-tuning of biological activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670921/
https://www.ncbi.nlm.nih.gov/pubmed/38003315
http://dx.doi.org/10.3390/ijms242216126
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