Up Front Unfolded Protein Response Combined with Early Protein Secretion Pathway Engineering in Yarrowia lipolytica to Attenuate ER Stress Caused by Enzyme Overproduction

Engineering the yeast Yarrowia lipolytica as an efficient host to produce recombinant proteins remains a longstanding goal for applied biocatalysis. During the protein overproduction, the accumulation of unfolded and misfolded proteins causes ER stress and cell dysfunction in Y. lipolytica. In this...

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Detalles Bibliográficos
Autores principales: Zhu, Xingyu, Li, Moying, Zhu, Rui, Xin, Yu, Guo, Zitao, Gu, Zhenghua, Zhang, Liang, Guo, Zhongpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670989/
https://www.ncbi.nlm.nih.gov/pubmed/38003616
http://dx.doi.org/10.3390/ijms242216426

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