Cargando…

C8ORF88: A Novel eIF4E-Binding Protein

Translation initiation in eukaryotes is regulated at several steps, one of which involves the availability of the cap binding protein to participate in cap-dependent protein synthesis. Binding of eIF4E to translational repressors (eIF4E-binding proteins [4E-BPs]) suppresses translation and is used b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pugsley, Lauren, Naineni, Sai Kiran, Amiri, Mehdi, Yanagiya, Akiko, Cencic, Regina, Sonenberg, Nahum, Pelletier, Jerry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670996/ https://www.ncbi.nlm.nih.gov/pubmed/38003019 http://dx.doi.org/10.3390/genes14112076

Ejemplares similares

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions
por: Steinberger, Jutta, et al.
Publicado: (2020)

A comparative study of small molecules targeting eIF4A
por: Naineni, Sai Kiran, et al.
Publicado: (2020)

RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes
por: Robert, Francis, et al.
Publicado: (2020)

The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase
por: Sun, Yingjie, et al.
Publicado: (2012)

Signalling to eIF4E in cancer
por: Siddiqui, Nadeem, et al.
Publicado: (2015)

Light-regulated translational control of circadian behavior by eIF4E phosphorylation
por: Cao, Ruifeng, et al.
Publicado: (2015)

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F
por: Chu, Jennifer, et al.
Publicado: (2020)

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio
por: Alain, Tommy, et al.
Publicado: (2012)

The Distribution of eIF4E-Family Members across Insecta
por: Tettweiler, Gritta, et al.
Publicado: (2012)

Nuclear Eukaryotic Initiation Factor 4e (Eif4e) Colocalizes with Splicing Factors in Speckles
por: Dostie, Josée, et al.
Publicado: (2000)

A forward genetic screen identifies modifiers of rocaglate responsiveness
por: Shen, Leo, et al.
Publicado: (2021)

The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior
por: Wiebe, Shane, et al.
Publicado: (2020)

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A
por: Chu, Jennifer, et al.
Publicado: (2016)

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation
por: Liberman, Noa, et al.
Publicado: (2015)

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay
por: Ferraiuolo, Maria A., et al.
Publicado: (2005)

Epigenetic Activation of a Subset of mRNAs by eIF4E Explains Its Effects on Cell Proliferation
por: Mamane, Yaël, et al.
Publicado: (2007)

Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference
por: Santhanam, Arti N., et al.
Publicado: (2009)

Correction: Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference
por: Santhanam, Arti N., et al.
Publicado: (2009)

eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis
por: Ruan, Hang, et al.
Publicado: (2020)

Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches
por: Martínez, Alba, et al.
Publicado: (2015)

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis
por: Zakaria, Chadi, et al.
Publicado: (2018)

Eukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation
por: Ross, Joseph A., et al.
Publicado: (2018)

eIF4AII is dispensable for miRNA-mediated gene silencing
por: Galicia-Vázquez, Gabriela, et al.
Publicado: (2015)

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
por: Robichaud, Nathaniel, et al.
Publicado: (2014)

eIF4G-driven translation initiation of downstream ORFs in mammalian cells
por: Nobuta, Risa, et al.
Publicado: (2020)

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
por: Svitkin, Yuri V., et al.
Publicado: (2017)

Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
por: Dawson, Jennifer E., et al.
Publicado: (2020)

Synergistic activation of eIF4A by eIF4B and eIF4G
por: Nielsen, Klaus H., et al.
Publicado: (2011)

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes
por: Gkogkas, Christos G., et al.
Publicado: (2014)

Translational Control in Stem Cells
por: Tahmasebi, Soroush, et al.
Publicado: (2019)

An eIF for proliferation
por: LeBrasseur, Nicole
Publicado: (2008)

The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells
por: González-Almela, Esther, et al.
Publicado: (2018)

Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E–eIF4G interactions
por: Yoffe, Yael, et al.
Publicado: (2009)

Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D
por: Sanz, Miguel Angel, et al.
Publicado: (2017)

4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass
por: Blandino-Rosano, Manuel, et al.
Publicado: (2016)

eIF4B, eIF4G and RNA regulate eIF4A activity in translation initiation by modulating the eIF4A conformational cycle
por: Harms, Ulf, et al.
Publicado: (2014)

Selectivity for eIF4E
por: LeBrasseur, Nicole
Publicado: (2005)

Loss-of-Function Analysis Reveals Distinct Requirements of the Translation Initiation Factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila Spermatogenesis
por: Ghosh, Sanjay, et al.
Publicado: (2015)

Targeting Translation Dependence in Cancer
por: Malina, Abba, et al.
Publicado: (2011)

Binding of eIF3 in complex with eIF5 and eIF1 to the 40S ribosomal subunit is accompanied by dramatic structural changes
por: Zeman, Jakub, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gsdemchdbo2r8ceekg3c8p3m6r