Cargando…

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

Stimulator of interferon genes (STING) agonists have shown potent anti-tumor efficacy in various mouse tumor models and have the potential to overcome resistance to immune checkpoint inhibitors (ICI) by linking the innate and acquired immune systems. First-generation STING agonists are administered...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jekle, Andreas, Thatikonda, Santosh Kumar, Jaisinghani, Ruchika, Ren, Suping, Kinkade, April, Stevens, Sarah K., Stoycheva, Antitsa, Rajwanshi, Vivek K., Williams, Caroline, Deval, Jerome, Mukherjee, Sucheta, Zhang, Qingling, Chanda, Sushmita, Smith, David B., Blatt, Lawrence M., Symons, Julian A., Gonzalvez, Francois, Beigelman, Leonid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671074/ https://www.ncbi.nlm.nih.gov/pubmed/38003463 http://dx.doi.org/10.3390/ijms242216274

Ejemplares similares

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model
por: Vandyck, Koen, et al.
Publicado: (2021)

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)
por: Luong, Xuan G., et al.
Publicado: (2020)

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry
por: Gurard-Levin, Zachary A., et al.
Publicado: (2020)

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate
por: Deval, Jerome, et al.
Publicado: (2015)

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir
por: Jochmans, Dirk, et al.
Publicado: (2023)

Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus
por: Deval, Jerome, et al.
Publicado: (2014)

Congenital myasthenic syndromes due to mutations in ALG2 and ALG14
por: Cossins, Judith, et al.
Publicado: (2013)

Structural Analysis of the Effect of Asn107Ser Mutation on Alg13 Activity and Alg13-Alg14 Complex Formation and Expanding the Phenotypic Variability of ALG13-CDG
por: Mitusińska, Karolina, et al.
Publicado: (2022)

The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
por: Finger, Fabian, et al.
Publicado: (2021)

Immunomodulation Therapy for Severe Aplastic Anemia: —ALG Versus ALG Plus Cyclosporin A—
por: Park, Chong Won, et al.
Publicado: (1989)

Developmental Characterization of the MicroRNA-Specific C. elegans Argonautes alg-1 and alg-2
por: Vasquez-Rifo, Alejandro, et al.
Publicado: (2012)

Chemo-enzymatic synthesis of lipid-linked GlcNAc(2)Man(5) oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins
por: Ramírez, Ana S, et al.
Publicado: (2017)

Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects
por: McClure, Matthew W., et al.
Publicado: (2018)

Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules
por: Kao, C. Cheng, et al.
Publicado: (2021)

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development
por: Liu, Cheng, et al.
Publicado: (2021)

ALG: Automated Genotype Calling of Luminex Assays
por: Bourgey, Mathieu, et al.
Publicado: (2011)

Clinical and Molecular Characterization of ALG1-CDG
por: Dhamija, Radhika, et al.
Publicado: (2016)

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase
por: Jordan, Paul C., et al.
Publicado: (2018)

ALG8-CDG: novel patients and review of the literature
por: Höck, Michaela, et al.
Publicado: (2015)

P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation
por: Baker, Perrin, et al.
Publicado: (2014)

Meiotic H3K9me2 distribution is influenced by the ALG-3 and ALG-4 pathway and by poly(U) polymerase activity
por: Li, Yini, et al.
Publicado: (2021)

Removal of Cu(II) by Fixed-Bed Columns Using Alg-Ch and Alg-ChS Hydrogel Beads: Effect of Operating Conditions on the Mass Transfer Zone
por: Verduzco-Navarro, Ilse Paulina, et al.
Publicado: (2020)

ALG9-CDG: New clinical case and review of the literature
por: Davis, Kellie, et al.
Publicado: (2017)

Expression of ALG3 in Hepatocellular Carcinoma and Its Clinical Implication
por: Zhao, Zhen, et al.
Publicado: (2022)

Mutations in Conserved Residues of the C. elegans microRNA Argonaute ALG-1 Identify Separable Functions in ALG-1 miRISC Loading and Target Repression
por: Zinovyeva, Anna Y., et al.
Publicado: (2014)

Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2(ΔGF122)) and structural roles of F122 in target recognition
por: Inuzuka, Tatsutoshi, et al.
Publicado: (2010)

The Ambiguous Base-Pairing and High Substrate Efficiency of T-705 (Favipiravir) Ribofuranosyl 5′-Triphosphate towards Influenza A Virus Polymerase
por: Jin, Zhinan, et al.
Publicado: (2013)

AlgPred: prediction of allergenic proteins and mapping of IgE epitopes
por: Saha, Sudipto, et al.
Publicado: (2006)

Multifaceted Roles of ALG-2 in Ca(2+)-Regulated Membrane Trafficking
por: Maki, Masatoshi, et al.
Publicado: (2016)

ALG11-CDG: Three novel mutations and further characterization of the phenotype
por: Regal, L., et al.
Publicado: (2014)

Immunization against Pseudomonas aeruginosa using Alg-PLGA nano-vaccine
por: Azimi, Saeid, et al.
Publicado: (2021)

NaAlg-g-AA Hydrogels: Candidates in Sustainable Agriculture Applications
por: Manaila, Elena, et al.
Publicado: (2023)

NeuronAlg: An Innovative Neuronal Computational Model for Immunofluorescence Image Segmentation
por: Giacopelli, Giuseppe, et al.
Publicado: (2023)

Heterozygosity of ALG9 in Association with Autosomal Dominant Polycystic Liver Disease
por: Boerrigter, Melissa M., et al.
Publicado: (2023)

Identification of ALG3 as a potential prognostic biomarker in lung adenocarcinoma
por: Yuan, Yinjiao, et al.
Publicado: (2023)

Intratumoral injection of STING ligand promotes abscopal effect
por: Baird, Jason R, et al.
Publicado: (2014)

Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2
por: Takahashi, Takeshi, et al.
Publicado: (2015)

Timing Measurements for the second Level Trigger software of ATLAS with TrigTimeAlgs
por: dodt, d
Publicado: (2003)

The Pseudomonas aeruginosa AlgZR two-component system coordinates multiple phenotypes
por: Okkotsu, Yuta, et al.
Publicado: (2014)

Characterization of AlgMsp, an Alginate Lyase from Microbulbifer sp. 6532A
por: Swift, Steven M., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vm69a1sma9j2mugbpj7kln1qsp