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Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort

Polycystic ovary syndrome (PCOS) is a medical condition with important consequences for women’s well-being and reproductive outcomes. Although the etiology of PCOS is not fully understood, there is increasing evidence of both genetic and environmental determinants, including development in early lif...

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Autores principales: Boldis, Beata Vivien, Grünberger, Ilona, Cederström, Agneta, Björk, Jonas, Nilsson, Anton, Helgertz, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671095/
https://www.ncbi.nlm.nih.gov/pubmed/37998314
http://dx.doi.org/10.3390/ijerph20227083
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author Boldis, Beata Vivien
Grünberger, Ilona
Cederström, Agneta
Björk, Jonas
Nilsson, Anton
Helgertz, Jonas
author_facet Boldis, Beata Vivien
Grünberger, Ilona
Cederström, Agneta
Björk, Jonas
Nilsson, Anton
Helgertz, Jonas
author_sort Boldis, Beata Vivien
collection PubMed
description Polycystic ovary syndrome (PCOS) is a medical condition with important consequences for women’s well-being and reproductive outcomes. Although the etiology of PCOS is not fully understood, there is increasing evidence of both genetic and environmental determinants, including development in early life. We studied a population of 977,637 singleton women born in in Sweden between 1973 and 1995, followed sometime between the age 15 and 40. The incidence of PCOS was measured using hospital register data during 2001–2012, complemented with information about the women’s, parents’ and sisters’ health and social characteristics from population and health care registers. Cox regression was used to study how PCOS is associated with intergenerational factors, and a range of early life characteristics. 11,594 women in the study sample were diagnosed with PCOS during the follow-up period. The hazard rate for PCOS was increased 3-fold (HR 2.98, 95% CI 2.43–3.64) if the index woman’s mother had been diagnosed with PCOS, and with 1.5-fold (HR 1.51, 95% CI 1.39–1.63) if their mother had diabetes mellitus. We found associations of PCOS with lower (<7) one-minute Apgar score (HR 1.19, 95% CI 1.09–1.29) and with post-term birth (HR 1.19, 95% CI 1.13–1.26). Furthermore, heavy (10+ cigarettes/day) maternal smoking (HR 1.30, 95% CI 1.18–1.44) and maternal obesity (HR 1.90, 95% CI 1.62–2.36) were strongly associated with PCOS. This study finds support for the heritability and fetal origins of PCOS. Risk of PCOS could be reduced by further emphasizing the importance of maternal and early life health.
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spelling pubmed-106710952023-11-20 Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort Boldis, Beata Vivien Grünberger, Ilona Cederström, Agneta Björk, Jonas Nilsson, Anton Helgertz, Jonas Int J Environ Res Public Health Article Polycystic ovary syndrome (PCOS) is a medical condition with important consequences for women’s well-being and reproductive outcomes. Although the etiology of PCOS is not fully understood, there is increasing evidence of both genetic and environmental determinants, including development in early life. We studied a population of 977,637 singleton women born in in Sweden between 1973 and 1995, followed sometime between the age 15 and 40. The incidence of PCOS was measured using hospital register data during 2001–2012, complemented with information about the women’s, parents’ and sisters’ health and social characteristics from population and health care registers. Cox regression was used to study how PCOS is associated with intergenerational factors, and a range of early life characteristics. 11,594 women in the study sample were diagnosed with PCOS during the follow-up period. The hazard rate for PCOS was increased 3-fold (HR 2.98, 95% CI 2.43–3.64) if the index woman’s mother had been diagnosed with PCOS, and with 1.5-fold (HR 1.51, 95% CI 1.39–1.63) if their mother had diabetes mellitus. We found associations of PCOS with lower (<7) one-minute Apgar score (HR 1.19, 95% CI 1.09–1.29) and with post-term birth (HR 1.19, 95% CI 1.13–1.26). Furthermore, heavy (10+ cigarettes/day) maternal smoking (HR 1.30, 95% CI 1.18–1.44) and maternal obesity (HR 1.90, 95% CI 1.62–2.36) were strongly associated with PCOS. This study finds support for the heritability and fetal origins of PCOS. Risk of PCOS could be reduced by further emphasizing the importance of maternal and early life health. MDPI 2023-11-20 /pmc/articles/PMC10671095/ /pubmed/37998314 http://dx.doi.org/10.3390/ijerph20227083 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boldis, Beata Vivien
Grünberger, Ilona
Cederström, Agneta
Björk, Jonas
Nilsson, Anton
Helgertz, Jonas
Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort
title Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort
title_full Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort
title_fullStr Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort
title_full_unstemmed Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort
title_short Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort
title_sort early life factors and polycystic ovary syndrome in a swedish birth cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671095/
https://www.ncbi.nlm.nih.gov/pubmed/37998314
http://dx.doi.org/10.3390/ijerph20227083
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