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Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler

The Drosophila melanogaster dADD1 and dXNP proteins are orthologues of the ADD and SNF2 domains of the vertebrate ATRX (Alpha-Thalassemia with mental Retardation X-related) protein. ATRX plays a role in general molecular processes, such as regulating chromatin status and gene expression, while dADD1...

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Detalles Bibliográficos
Autores principales: Melnikova, Larisa, Golovnin, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671109/
https://www.ncbi.nlm.nih.gov/pubmed/38003676
http://dx.doi.org/10.3390/ijms242216486
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author Melnikova, Larisa
Golovnin, Anton
author_facet Melnikova, Larisa
Golovnin, Anton
author_sort Melnikova, Larisa
collection PubMed
description The Drosophila melanogaster dADD1 and dXNP proteins are orthologues of the ADD and SNF2 domains of the vertebrate ATRX (Alpha-Thalassemia with mental Retardation X-related) protein. ATRX plays a role in general molecular processes, such as regulating chromatin status and gene expression, while dADD1 and dXNP have similar functions in the Drosophila genome. Both ATRX and dADD1/dXNP interact with various protein partners and participate in various regulatory complexes. Disruption of ATRX expression in humans leads to the development of α-thalassemia and cancer, especially glioma. However, the mechanisms that allow ATRX to regulate various cellular processes are poorly understood. Studying the functioning of dADD1/dXNP in the Drosophila model may contribute to understanding the mechanisms underlying the multifunctional action of ATRX and its connection with various cellular processes. This review provides a brief overview of the currently available information in mammals and Drosophila regarding the roles of ATRX, dXNP, and dADD1. It discusses possible mechanisms of action of complexes involving these proteins.
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spelling pubmed-106711092023-11-18 Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler Melnikova, Larisa Golovnin, Anton Int J Mol Sci Review The Drosophila melanogaster dADD1 and dXNP proteins are orthologues of the ADD and SNF2 domains of the vertebrate ATRX (Alpha-Thalassemia with mental Retardation X-related) protein. ATRX plays a role in general molecular processes, such as regulating chromatin status and gene expression, while dADD1 and dXNP have similar functions in the Drosophila genome. Both ATRX and dADD1/dXNP interact with various protein partners and participate in various regulatory complexes. Disruption of ATRX expression in humans leads to the development of α-thalassemia and cancer, especially glioma. However, the mechanisms that allow ATRX to regulate various cellular processes are poorly understood. Studying the functioning of dADD1/dXNP in the Drosophila model may contribute to understanding the mechanisms underlying the multifunctional action of ATRX and its connection with various cellular processes. This review provides a brief overview of the currently available information in mammals and Drosophila regarding the roles of ATRX, dXNP, and dADD1. It discusses possible mechanisms of action of complexes involving these proteins. MDPI 2023-11-18 /pmc/articles/PMC10671109/ /pubmed/38003676 http://dx.doi.org/10.3390/ijms242216486 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Melnikova, Larisa
Golovnin, Anton
Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler
title Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler
title_full Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler
title_fullStr Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler
title_full_unstemmed Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler
title_short Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler
title_sort multiple roles of dxnp and dadd1—drosophila orthologs of atrx chromatin remodeler
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671109/
https://www.ncbi.nlm.nih.gov/pubmed/38003676
http://dx.doi.org/10.3390/ijms242216486
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