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Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler
The Drosophila melanogaster dADD1 and dXNP proteins are orthologues of the ADD and SNF2 domains of the vertebrate ATRX (Alpha-Thalassemia with mental Retardation X-related) protein. ATRX plays a role in general molecular processes, such as regulating chromatin status and gene expression, while dADD1...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671109/ https://www.ncbi.nlm.nih.gov/pubmed/38003676 http://dx.doi.org/10.3390/ijms242216486 |
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author | Melnikova, Larisa Golovnin, Anton |
author_facet | Melnikova, Larisa Golovnin, Anton |
author_sort | Melnikova, Larisa |
collection | PubMed |
description | The Drosophila melanogaster dADD1 and dXNP proteins are orthologues of the ADD and SNF2 domains of the vertebrate ATRX (Alpha-Thalassemia with mental Retardation X-related) protein. ATRX plays a role in general molecular processes, such as regulating chromatin status and gene expression, while dADD1 and dXNP have similar functions in the Drosophila genome. Both ATRX and dADD1/dXNP interact with various protein partners and participate in various regulatory complexes. Disruption of ATRX expression in humans leads to the development of α-thalassemia and cancer, especially glioma. However, the mechanisms that allow ATRX to regulate various cellular processes are poorly understood. Studying the functioning of dADD1/dXNP in the Drosophila model may contribute to understanding the mechanisms underlying the multifunctional action of ATRX and its connection with various cellular processes. This review provides a brief overview of the currently available information in mammals and Drosophila regarding the roles of ATRX, dXNP, and dADD1. It discusses possible mechanisms of action of complexes involving these proteins. |
format | Online Article Text |
id | pubmed-10671109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106711092023-11-18 Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler Melnikova, Larisa Golovnin, Anton Int J Mol Sci Review The Drosophila melanogaster dADD1 and dXNP proteins are orthologues of the ADD and SNF2 domains of the vertebrate ATRX (Alpha-Thalassemia with mental Retardation X-related) protein. ATRX plays a role in general molecular processes, such as regulating chromatin status and gene expression, while dADD1 and dXNP have similar functions in the Drosophila genome. Both ATRX and dADD1/dXNP interact with various protein partners and participate in various regulatory complexes. Disruption of ATRX expression in humans leads to the development of α-thalassemia and cancer, especially glioma. However, the mechanisms that allow ATRX to regulate various cellular processes are poorly understood. Studying the functioning of dADD1/dXNP in the Drosophila model may contribute to understanding the mechanisms underlying the multifunctional action of ATRX and its connection with various cellular processes. This review provides a brief overview of the currently available information in mammals and Drosophila regarding the roles of ATRX, dXNP, and dADD1. It discusses possible mechanisms of action of complexes involving these proteins. MDPI 2023-11-18 /pmc/articles/PMC10671109/ /pubmed/38003676 http://dx.doi.org/10.3390/ijms242216486 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Melnikova, Larisa Golovnin, Anton Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler |
title | Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler |
title_full | Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler |
title_fullStr | Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler |
title_full_unstemmed | Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler |
title_short | Multiple Roles of dXNP and dADD1—Drosophila Orthologs of ATRX Chromatin Remodeler |
title_sort | multiple roles of dxnp and dadd1—drosophila orthologs of atrx chromatin remodeler |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671109/ https://www.ncbi.nlm.nih.gov/pubmed/38003676 http://dx.doi.org/10.3390/ijms242216486 |
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