Cargando…
HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article
Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) accounting for around one-third of all HCC cases. Prolonged inflammation in chronic hepatitis C (CHC), maintained through a variety of pro- and anti-inflammatory mediators, is one of the aspects of carcinogenesis, followed by...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671156/ https://www.ncbi.nlm.nih.gov/pubmed/38003240 http://dx.doi.org/10.3390/ijms242216048 |
_version_ | 1785140088475222016 |
---|---|
author | Milosevic, Ivana Todorovic, Nevena Filipovic, Ana Simic, Jelena Markovic, Marko Stevanovic, Olja Malinic, Jovan Katanic, Natasa Mitrovic, Nikola Nikolic, Natasa |
author_facet | Milosevic, Ivana Todorovic, Nevena Filipovic, Ana Simic, Jelena Markovic, Marko Stevanovic, Olja Malinic, Jovan Katanic, Natasa Mitrovic, Nikola Nikolic, Natasa |
author_sort | Milosevic, Ivana |
collection | PubMed |
description | Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) accounting for around one-third of all HCC cases. Prolonged inflammation in chronic hepatitis C (CHC), maintained through a variety of pro- and anti-inflammatory mediators, is one of the aspects of carcinogenesis, followed by mitochondrial dysfunction and oxidative stress. Immune response dysfunction including the innate and adaptive immunity also plays a role in the development, as well as in the recurrence of HCC after treatment. Some of the tumor suppressor genes inhibited by the HCV proteins are p53, p73, and retinoblastoma 1. Mutations in the telomerase reverse transcriptase promoter and the oncogene catenin beta 1 are two more important carcinogenic signaling pathways in HCC associated with HCV. Furthermore, in HCV-related HCC, numerous tumor suppressor and seven oncogenic genes are dysregulated by epigenetic changes. Epigenetic regulation of gene expression is considered as a lasting “epigenetic memory”, suggesting that HCV-induced changes persist and are associated with liver carcinogenesis even after cure. Epigenetic changes and immune response dysfunction are recognized targets for potential therapy of HCC. |
format | Online Article Text |
id | pubmed-10671156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106711562023-11-07 HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article Milosevic, Ivana Todorovic, Nevena Filipovic, Ana Simic, Jelena Markovic, Marko Stevanovic, Olja Malinic, Jovan Katanic, Natasa Mitrovic, Nikola Nikolic, Natasa Int J Mol Sci Review Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) accounting for around one-third of all HCC cases. Prolonged inflammation in chronic hepatitis C (CHC), maintained through a variety of pro- and anti-inflammatory mediators, is one of the aspects of carcinogenesis, followed by mitochondrial dysfunction and oxidative stress. Immune response dysfunction including the innate and adaptive immunity also plays a role in the development, as well as in the recurrence of HCC after treatment. Some of the tumor suppressor genes inhibited by the HCV proteins are p53, p73, and retinoblastoma 1. Mutations in the telomerase reverse transcriptase promoter and the oncogene catenin beta 1 are two more important carcinogenic signaling pathways in HCC associated with HCV. Furthermore, in HCV-related HCC, numerous tumor suppressor and seven oncogenic genes are dysregulated by epigenetic changes. Epigenetic regulation of gene expression is considered as a lasting “epigenetic memory”, suggesting that HCV-induced changes persist and are associated with liver carcinogenesis even after cure. Epigenetic changes and immune response dysfunction are recognized targets for potential therapy of HCC. MDPI 2023-11-07 /pmc/articles/PMC10671156/ /pubmed/38003240 http://dx.doi.org/10.3390/ijms242216048 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Milosevic, Ivana Todorovic, Nevena Filipovic, Ana Simic, Jelena Markovic, Marko Stevanovic, Olja Malinic, Jovan Katanic, Natasa Mitrovic, Nikola Nikolic, Natasa HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article |
title | HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article |
title_full | HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article |
title_fullStr | HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article |
title_full_unstemmed | HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article |
title_short | HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article |
title_sort | hcv and hcc tango—deciphering the intricate dance of disease: a review article |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671156/ https://www.ncbi.nlm.nih.gov/pubmed/38003240 http://dx.doi.org/10.3390/ijms242216048 |
work_keys_str_mv | AT milosevicivana hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle AT todorovicnevena hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle AT filipovicana hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle AT simicjelena hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle AT markovicmarko hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle AT stevanovicolja hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle AT malinicjovan hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle AT katanicnatasa hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle AT mitrovicnikola hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle AT nikolicnatasa hcvandhcctangodecipheringtheintricatedanceofdiseaseareviewarticle |