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HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article

Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) accounting for around one-third of all HCC cases. Prolonged inflammation in chronic hepatitis C (CHC), maintained through a variety of pro- and anti-inflammatory mediators, is one of the aspects of carcinogenesis, followed by...

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Autores principales: Milosevic, Ivana, Todorovic, Nevena, Filipovic, Ana, Simic, Jelena, Markovic, Marko, Stevanovic, Olja, Malinic, Jovan, Katanic, Natasa, Mitrovic, Nikola, Nikolic, Natasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671156/
https://www.ncbi.nlm.nih.gov/pubmed/38003240
http://dx.doi.org/10.3390/ijms242216048
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author Milosevic, Ivana
Todorovic, Nevena
Filipovic, Ana
Simic, Jelena
Markovic, Marko
Stevanovic, Olja
Malinic, Jovan
Katanic, Natasa
Mitrovic, Nikola
Nikolic, Natasa
author_facet Milosevic, Ivana
Todorovic, Nevena
Filipovic, Ana
Simic, Jelena
Markovic, Marko
Stevanovic, Olja
Malinic, Jovan
Katanic, Natasa
Mitrovic, Nikola
Nikolic, Natasa
author_sort Milosevic, Ivana
collection PubMed
description Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) accounting for around one-third of all HCC cases. Prolonged inflammation in chronic hepatitis C (CHC), maintained through a variety of pro- and anti-inflammatory mediators, is one of the aspects of carcinogenesis, followed by mitochondrial dysfunction and oxidative stress. Immune response dysfunction including the innate and adaptive immunity also plays a role in the development, as well as in the recurrence of HCC after treatment. Some of the tumor suppressor genes inhibited by the HCV proteins are p53, p73, and retinoblastoma 1. Mutations in the telomerase reverse transcriptase promoter and the oncogene catenin beta 1 are two more important carcinogenic signaling pathways in HCC associated with HCV. Furthermore, in HCV-related HCC, numerous tumor suppressor and seven oncogenic genes are dysregulated by epigenetic changes. Epigenetic regulation of gene expression is considered as a lasting “epigenetic memory”, suggesting that HCV-induced changes persist and are associated with liver carcinogenesis even after cure. Epigenetic changes and immune response dysfunction are recognized targets for potential therapy of HCC.
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spelling pubmed-106711562023-11-07 HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article Milosevic, Ivana Todorovic, Nevena Filipovic, Ana Simic, Jelena Markovic, Marko Stevanovic, Olja Malinic, Jovan Katanic, Natasa Mitrovic, Nikola Nikolic, Natasa Int J Mol Sci Review Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) accounting for around one-third of all HCC cases. Prolonged inflammation in chronic hepatitis C (CHC), maintained through a variety of pro- and anti-inflammatory mediators, is one of the aspects of carcinogenesis, followed by mitochondrial dysfunction and oxidative stress. Immune response dysfunction including the innate and adaptive immunity also plays a role in the development, as well as in the recurrence of HCC after treatment. Some of the tumor suppressor genes inhibited by the HCV proteins are p53, p73, and retinoblastoma 1. Mutations in the telomerase reverse transcriptase promoter and the oncogene catenin beta 1 are two more important carcinogenic signaling pathways in HCC associated with HCV. Furthermore, in HCV-related HCC, numerous tumor suppressor and seven oncogenic genes are dysregulated by epigenetic changes. Epigenetic regulation of gene expression is considered as a lasting “epigenetic memory”, suggesting that HCV-induced changes persist and are associated with liver carcinogenesis even after cure. Epigenetic changes and immune response dysfunction are recognized targets for potential therapy of HCC. MDPI 2023-11-07 /pmc/articles/PMC10671156/ /pubmed/38003240 http://dx.doi.org/10.3390/ijms242216048 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Milosevic, Ivana
Todorovic, Nevena
Filipovic, Ana
Simic, Jelena
Markovic, Marko
Stevanovic, Olja
Malinic, Jovan
Katanic, Natasa
Mitrovic, Nikola
Nikolic, Natasa
HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article
title HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article
title_full HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article
title_fullStr HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article
title_full_unstemmed HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article
title_short HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article
title_sort hcv and hcc tango—deciphering the intricate dance of disease: a review article
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671156/
https://www.ncbi.nlm.nih.gov/pubmed/38003240
http://dx.doi.org/10.3390/ijms242216048
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