Cargando…

The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer’s Disease

Despite decades of intense research, disease-modifying therapeutic approaches for Alzheimer’s disease (AD) are still very much needed. Apart from the extensively analyzed tau and amyloid pathological cascades, two promising avenues of research that may eventually identify new druggable targets for A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zegarra-Valdivia, Jonathan A., Pignatelli, Jaime, Nuñez, Angel, Torres Aleman, Ignacio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671249/ https://www.ncbi.nlm.nih.gov/pubmed/38003628 http://dx.doi.org/10.3390/ijms242216440

Ejemplares similares

Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons
por: Fernández de Sevilla, M. Estrella, et al.
Publicado: (2022)

Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology
por: Zegarra-Valdivia, Jonathan, et al.
Publicado: (2022)

Response Facilitation Induced by Insulin-like Growth Factor-I in the Primary Somatosensory Cortex of Mice Was Reduced in Aging
por: García-Magro, Nuria, et al.
Publicado: (2022)

Untangling IGF-I signaling in the aging brain
por: Zegarra-Valdivia, Jonathan, et al.
Publicado: (2023)

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse
por: Zegarra-Valdivia, Jonathan A., et al.
Publicado: (2021)

Circulating Insulin-Like Growth Factor I is Involved in the Effect of High Fat Diet on Peripheral Amyloid β Clearance
por: Herrero-Labrador, Raquel, et al.
Publicado: (2020)

Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice
por: Munive, Victor, et al.
Publicado: (2019)

Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons
por: Pignatelli, Jaime, et al.
Publicado: (2022)

Cognitive Deficits in Aging Related to Changes in Basal Forebrain Neuronal Activity
por: Chaves-Coira, Irene, et al.
Publicado: (2023)

Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man
por: Santi, A., et al.
Publicado: (2018)

Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons
por: Franco, Carolina, et al.
Publicado: (2012)

A Concerted Action Of Estradiol And Insulin Like Growth Factor I Underlies Sex Differences In Mood Regulation By Exercise
por: Munive, Victor, et al.
Publicado: (2016)

Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury
por: Genis, Laura, et al.
Publicado: (2014)

Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer’s Disease
por: Carroll, Trae, et al.
Publicado: (2021)

Selective vulnerability to atrophy in sporadic Creutzfeldt‐Jakob disease
por: Younes, Kyan, et al.
Publicado: (2021)

Editorial: Insulin and The Brain
por: Taouis, Mohammed, et al.
Publicado: (2019)

Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer's Disease Cases
por: Ho, Lap, et al.
Publicado: (2012)

Insulin Peptides as Mediators of the Impact of Life Style in Alzheimer’s disease
por: Fernandez, A.M., et al.
Publicado: (2018)

Mammalian sperm nuclear organization: resiliencies and vulnerabilities
por: Champroux, A., et al.
Publicado: (2016)

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease
por: Traxler, Larissa, et al.
Publicado: (2022)

Understanding vulnerability and resilience in Somalia
por: Lwanga-Ntale, Charles, et al.
Publicado: (2020)

Anandamide Effects in a Streptozotocin-Induced Alzheimer’s Disease-Like Sporadic Dementia in Rats
por: Moreira-Silva, Daniel, et al.
Publicado: (2018)

The Rat Brain Transcriptome: From Infancy to Aging and Sporadic Alzheimer’s Disease-like Pathology
por: Stefanova, Natalia A., et al.
Publicado: (2023)

Vulnerability and resilience to Alzheimer’s disease: early life conditions modulate neuropathology and determine cognitive reserve
por: Lesuis, Sylvie L., et al.
Publicado: (2018)

Effects of locally applied Insulin-like Growth Factor-I on osseointegration
por: López-Quiles, Juan, et al.
Publicado: (2019)

Resilience and vulnerability: a neurobiological perspective
por: Karatsoreos, Ilia N., et al.
Publicado: (2013)

Resilience and Vulnerability to Pain and Inflammation in the Hippocampus
por: Vasic, Verica, et al.
Publicado: (2017)

Assessing Cyberbiosecurity Vulnerabilities and Infrastructure Resilience
por: Schabacker, Daniel S., et al.
Publicado: (2019)

Heterogeneity in Vulnerability and Resilience Among Centenarians
por: Jopp, Daniela, et al.
Publicado: (2021)

Migration, Resilience, Vulnerability and Migrants’ Health
por: Mwanri, Lillian, et al.
Publicado: (2022)

Vulnerable Waters are Essential to Watershed Resilience
por: Lane, Charles R., et al.
Publicado: (2022)

Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer’s Disease
por: Galle, Sara A., et al.
Publicado: (2019)

Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour
por: Matsubara, Fumiaki, et al.
Publicado: (2016)

Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats
por: Stefanova, Natalia A., et al.
Publicado: (2014)

Transcriptomic profiling of sporadic Alzheimer’s disease patients
por: Caldwell, Andrew B., et al.
Publicado: (2022)

Dipeptidyl peptidase 4 contributes to Alzheimer’s disease–like defects in a mouse model and is increased in sporadic Alzheimer’s disease brains
por: Valverde, Audrey, et al.
Publicado: (2021)

Healthy Adults Display Long-Term Trait-Like Neurobehavioral Resilience and Vulnerability to Sleep Loss
por: Dennis, Laura E., et al.
Publicado: (2017)

Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice
por: Trueba-Sáiz, A, et al.
Publicado: (2013)

Stress, vulnerability and resilience, a developmental approach
por: Broekman, Birit Froukje Philippien
Publicado: (2011)

Editorial: Resilience and Vulnerability Factors in Response to Stress
por: Martin-Soelch, Chantal, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bmfe9sdiodkfqmt7c6v1aqcpij