Cargando…

Kinesin Family Member C1 (KIFC1/HSET) Underlies Aggressive Disease in Androgen Receptor-Low and Basal-Like Triple-Negative Breast Cancers

Quadruple-negative breast cancer (QNBC) lacks traditional actionable targets, including androgen receptor (AR). QNBC disproportionately afflicts and impacts patients of African genetic ancestry. Kinesin family member C1 (KIFC1/HSET), a centrosome clustering protein that prevents cancer cells from un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jinna, Nikita, Yuan, Yate-Ching, Rida, Padmashree
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671256/ https://www.ncbi.nlm.nih.gov/pubmed/38003261 http://dx.doi.org/10.3390/ijms242216072

Ejemplares similares

Kinesin Family Member C1 (KIFC1/HSET): A Potential Actionable Biomarker of Early Stage Breast Tumorigenesis and Progression of High-Risk Lesions
por: Wright, Nikita, et al.
Publicado: (2021)

Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes
por: Saint-Dizier, François, et al.
Publicado: (2023)

Kinesin-14 HSET may not oppose kinesin-5 Eg5 activity in RPE-1 cells
por: Carlier-Grynkorn, Frederique, et al.
Publicado: (2022)

Adaptation to Hypoxia May Promote Therapeutic Resistance to Androgen Receptor Inhibition in Triple-Negative Breast Cancer
por: Jinna, Nikita, et al.
Publicado: (2022)

An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors
por: Wu, Hao, et al.
Publicado: (2022)

A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas
por: Mittal, Karuna, et al.
Publicado: (2016)

Kinesin KIFC1 actively transports bare double-stranded DNA
por: Farina, Francesca, et al.
Publicado: (2013)

Molecular Features of Androgen-Receptor Low, Estrogen Receptor-Negative Breast Cancers in the Carolina Breast Cancer Study
por: Jinna, Nikita, et al.
Publicado: (2023)

Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability
por: Chen, Shengyao, et al.
Publicado: (2016)

Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer
por: Ogden, Angela, et al.
Publicado: (2017)

Molecular features of androgen-receptor low, estrogen receptor-negative breast cancers in the Carolina breast cancer study
por: Jinna, Nikita D., et al.
Publicado: (2023)

Kinesin-14 motor protein KIFC1 participates in DNA synthesis and chromatin maintenance
por: Wei, Ya-Lan, et al.
Publicado: (2019)

Kinesin superfamily member KIFC2 as an independent prognostic biomarker of colon adenocarcinoma associated with poor immune response
por: Chen, Tao, et al.
Publicado: (2023)

Minus end-directed kinesin-14 KIFC1 regulates the positioning and architecture of the Golgi apparatus
por: She, Zhen-Yu, et al.
Publicado: (2017)

The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity
por: Lecordier, Laurence, et al.
Publicado: (2020)

HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients
por: Pannu, Vaishali, et al.
Publicado: (2015)

C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma
por: Xiao, Yu-Xi, et al.
Publicado: (2017)

Racial Disparity in Quadruple Negative Breast Cancer: Aggressive Biology and Potential Therapeutic Targeting and Prevention
por: Jinna, Nikita, et al.
Publicado: (2022)

Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer
por: Li, Jiangning, et al.
Publicado: (2020)

The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle
por: Mountain, Vicki, et al.
Publicado: (1999)

Kinesin Family Member C1 (KIFC1) Accelerates Proliferation and Invasion of Endometrial Cancer Cells Through Modulating the PI3K/AKT Signaling Pathway
por: Zhou, Kening, et al.
Publicado: (2020)

Panoptic Overview of Triple-Negative Breast Cancer in Nigeria: Current Challenges and Promising Global Initiatives
por: Wright, Nikita, et al.
Publicado: (2018)

The kinesin-14 family motor protein KIFC2 promotes prostate cancer progression by regulating p65
por: Liu, Xinyu, et al.
Publicado: (2023)

KIFC1 Is Associated with Basal Type, Cisplatin Resistance, PD-L1 Expression and Poor Prognosis in Bladder Cancer
por: Sekino, Yohei, et al.
Publicado: (2021)

Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization
por: Cao, Yujie, et al.
Publicado: (2020)

Rampant centrosome amplification underlies more aggressive disease course of triple negative breast cancers
por: Pannu, Vaishali, et al.
Publicado: (2015)

IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis
por: Vitre, Benjamin, et al.
Publicado: (2020)

Kinesin Motor Protein KIFC1 Is a Target Protein of miR-338-3p and Is Associated With Poor Prognosis and Progression of Renal Cell Carcinoma
por: Li, Gang, et al.
Publicado: (2018)

KIFC1: a promising chemotherapy target for cancer treatment?
por: Xiao, Yu-Xi, et al.
Publicado: (2016)

Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects
por: Zhi, Erlei, et al.
Publicado: (2016)

KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo
por: Wang, Xing, et al.
Publicado: (2019)

Prognostic Value and Immunological Role of KIFC1 in Hepatocellular Carcinoma
por: Li, Dan, et al.
Publicado: (2022)

Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters
por: Norris, Stephen R., et al.
Publicado: (2018)

High KIFC1 expression is associated with poor prognosis in prostate cancer
por: Kostecka, Laurie G., et al.
Publicado: (2021)

The Roles of KIFC1 in the Development of Osteosarcoma: Characterization of Potential Therapeutic Targets
por: Liang, Li-Yan, et al.
Publicado: (2022)

[Retracted] KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo
por: Wang, Xing, et al.
Publicado: (2023)

USF1 and hSET1A Mediated Epigenetic Modifications Regulate Lineage Differentiation and HoxB4 Transcription
por: Deng, Changwang, et al.
Publicado: (2013)

The DARC Side of Inflamm-Aging: Duffy Antigen Receptor for Chemokines (DARC/ACKR1) as a Potential Biomarker of Aging, Immunosenescence, and Breast Oncogenesis among High-Risk Subpopulations
por: Jinna, Nikita, et al.
Publicado: (2022)

Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway
por: Li, Zhi, et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes
por: Watts, Ciorsdaidh A., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_o7g2e8as3d40eq4ukuo9mu9a8v