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Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

This systematic review aims to evaluate the influence of environmental enrichment (EE) on oncological factors in experimental studies involving various types of cancer models. A comprehensive search was conducted in three databases: PubMed (161 articles), Embase (335 articles), and Scopus (274 artic...

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Autores principales: Fernandes, Matheus Santos de Sousa, Lacerda, Tiago Ramos, Fidélis, Débora Eduarda da Silva, Santos, Gabriela Carvalho Jurema, Filgueira, Tayrine Ordonio, de Souza, Raphael Fabrício, Lagranha, Claúdia Jacques, Lira, Fábio S., Castoldi, Angela, Souto, Fabrício Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671353/
https://www.ncbi.nlm.nih.gov/pubmed/38003706
http://dx.doi.org/10.3390/ijms242216516
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author Fernandes, Matheus Santos de Sousa
Lacerda, Tiago Ramos
Fidélis, Débora Eduarda da Silva
Santos, Gabriela Carvalho Jurema
Filgueira, Tayrine Ordonio
de Souza, Raphael Fabrício
Lagranha, Claúdia Jacques
Lira, Fábio S.
Castoldi, Angela
Souto, Fabrício Oliveira
author_facet Fernandes, Matheus Santos de Sousa
Lacerda, Tiago Ramos
Fidélis, Débora Eduarda da Silva
Santos, Gabriela Carvalho Jurema
Filgueira, Tayrine Ordonio
de Souza, Raphael Fabrício
Lagranha, Claúdia Jacques
Lira, Fábio S.
Castoldi, Angela
Souto, Fabrício Oliveira
author_sort Fernandes, Matheus Santos de Sousa
collection PubMed
description This systematic review aims to evaluate the influence of environmental enrichment (EE) on oncological factors in experimental studies involving various types of cancer models. A comprehensive search was conducted in three databases: PubMed (161 articles), Embase (335 articles), and Scopus (274 articles). Eligibility criteria were applied based on the PICOS strategy to minimize bias. Two independent researchers performed the searches, with a third participant resolving any discrepancies. The selected articles were analyzed, and data regarding sample characteristics and EE protocols were extracted. The outcomes focused solely on cancer and tumor-related parameters, including cancer type, description of the cancer model, angiogenesis, tumor occurrence, volume, weight, mice with tumors, and tumor inhibition rate. A total of 770 articles were identified across the three databases, with 12 studies meeting the inclusion criteria for this systematic review. The findings demonstrated that different EE protocols were effective in significantly reducing various aspects of tumor growth and development, such as angiogenesis, volume, weight, and the number of mice with tumors. Furthermore, EE enhanced the rate of tumor inhibition in mouse cancer models. This systematic review qualitatively demonstrates the impacts of EE protocols on multiple parameters associated with tumor growth and development, including angiogenesis, occurrence, volume, weight, and tumor incidence. Moreover, EE demonstrated the potential to increase the rate of tumor inhibition. These findings underscore the importance of EE as a valuable tool in the management of cancer.
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spelling pubmed-106713532023-11-20 Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review Fernandes, Matheus Santos de Sousa Lacerda, Tiago Ramos Fidélis, Débora Eduarda da Silva Santos, Gabriela Carvalho Jurema Filgueira, Tayrine Ordonio de Souza, Raphael Fabrício Lagranha, Claúdia Jacques Lira, Fábio S. Castoldi, Angela Souto, Fabrício Oliveira Int J Mol Sci Review This systematic review aims to evaluate the influence of environmental enrichment (EE) on oncological factors in experimental studies involving various types of cancer models. A comprehensive search was conducted in three databases: PubMed (161 articles), Embase (335 articles), and Scopus (274 articles). Eligibility criteria were applied based on the PICOS strategy to minimize bias. Two independent researchers performed the searches, with a third participant resolving any discrepancies. The selected articles were analyzed, and data regarding sample characteristics and EE protocols were extracted. The outcomes focused solely on cancer and tumor-related parameters, including cancer type, description of the cancer model, angiogenesis, tumor occurrence, volume, weight, mice with tumors, and tumor inhibition rate. A total of 770 articles were identified across the three databases, with 12 studies meeting the inclusion criteria for this systematic review. The findings demonstrated that different EE protocols were effective in significantly reducing various aspects of tumor growth and development, such as angiogenesis, volume, weight, and the number of mice with tumors. Furthermore, EE enhanced the rate of tumor inhibition in mouse cancer models. This systematic review qualitatively demonstrates the impacts of EE protocols on multiple parameters associated with tumor growth and development, including angiogenesis, occurrence, volume, weight, and tumor incidence. Moreover, EE demonstrated the potential to increase the rate of tumor inhibition. These findings underscore the importance of EE as a valuable tool in the management of cancer. MDPI 2023-11-20 /pmc/articles/PMC10671353/ /pubmed/38003706 http://dx.doi.org/10.3390/ijms242216516 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fernandes, Matheus Santos de Sousa
Lacerda, Tiago Ramos
Fidélis, Débora Eduarda da Silva
Santos, Gabriela Carvalho Jurema
Filgueira, Tayrine Ordonio
de Souza, Raphael Fabrício
Lagranha, Claúdia Jacques
Lira, Fábio S.
Castoldi, Angela
Souto, Fabrício Oliveira
Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review
title Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review
title_full Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review
title_fullStr Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review
title_full_unstemmed Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review
title_short Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review
title_sort environmental enrichment in cancer as a possible tool to combat tumor development: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671353/
https://www.ncbi.nlm.nih.gov/pubmed/38003706
http://dx.doi.org/10.3390/ijms242216516
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