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Adenoviral Gene Therapy Vectors in Clinical Use—Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety

Adenoviral vectors are commonly used in clinical gene therapy. Apart from oncolytic adenoviruses, vector replication is highly undesired as it may pose a safety risk for the treated patient. Thus, careful monitoring for the formation of replication-competent adenoviruses (RCA) during vector manufact...

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Detalles Bibliográficos
Autores principales:	Leikas, Aleksi J., Ylä-Herttuala, Seppo, Hartikainen, Juha E. K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671366/ https://www.ncbi.nlm.nih.gov/pubmed/38003709 http://dx.doi.org/10.3390/ijms242216519

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