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Genetic Interactions in Various Environmental Conditions in Caenorhabditis elegans
Although it is well known that epistasis plays an important role in many evolutionary processes (e.g., speciation, evolution of sex), our knowledge on the frequency and prevalent sign of epistatic interactions is mainly limited to unicellular organisms or cell cultures of multicellular organisms. Th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671385/ https://www.ncbi.nlm.nih.gov/pubmed/38003023 http://dx.doi.org/10.3390/genes14112080 |
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author | Toch, Katarzyna Buczek, Mateusz Labocha, Marta K. |
author_facet | Toch, Katarzyna Buczek, Mateusz Labocha, Marta K. |
author_sort | Toch, Katarzyna |
collection | PubMed |
description | Although it is well known that epistasis plays an important role in many evolutionary processes (e.g., speciation, evolution of sex), our knowledge on the frequency and prevalent sign of epistatic interactions is mainly limited to unicellular organisms or cell cultures of multicellular organisms. This is even more pronounced in regard to how the environment can influence genetic interactions. To broaden our knowledge in that respect we studied gene–gene interactions in a whole multicellular organism, Caenorhabditis elegans. We screened over one thousand gene interactions, each one in standard laboratory conditions, and under three different stressors: heat shock, oxidative stress, and genotoxic stress. Depending on the condition, between 7% and 22% of gene pairs showed significant genetic interactions and an overall sign of epistasis changed depending on the condition. Sign epistasis was quite common, but reciprocal sign epistasis was extremally rare. One interaction was common to all conditions, whereas 78% of interactions were specific to only one environment. Although epistatic interactions are quite common, their impact on evolutionary processes will strongly depend on environmental factors. |
format | Online Article Text |
id | pubmed-10671385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106713852023-11-15 Genetic Interactions in Various Environmental Conditions in Caenorhabditis elegans Toch, Katarzyna Buczek, Mateusz Labocha, Marta K. Genes (Basel) Article Although it is well known that epistasis plays an important role in many evolutionary processes (e.g., speciation, evolution of sex), our knowledge on the frequency and prevalent sign of epistatic interactions is mainly limited to unicellular organisms or cell cultures of multicellular organisms. This is even more pronounced in regard to how the environment can influence genetic interactions. To broaden our knowledge in that respect we studied gene–gene interactions in a whole multicellular organism, Caenorhabditis elegans. We screened over one thousand gene interactions, each one in standard laboratory conditions, and under three different stressors: heat shock, oxidative stress, and genotoxic stress. Depending on the condition, between 7% and 22% of gene pairs showed significant genetic interactions and an overall sign of epistasis changed depending on the condition. Sign epistasis was quite common, but reciprocal sign epistasis was extremally rare. One interaction was common to all conditions, whereas 78% of interactions were specific to only one environment. Although epistatic interactions are quite common, their impact on evolutionary processes will strongly depend on environmental factors. MDPI 2023-11-15 /pmc/articles/PMC10671385/ /pubmed/38003023 http://dx.doi.org/10.3390/genes14112080 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Toch, Katarzyna Buczek, Mateusz Labocha, Marta K. Genetic Interactions in Various Environmental Conditions in Caenorhabditis elegans |
title | Genetic Interactions in Various Environmental Conditions in Caenorhabditis elegans |
title_full | Genetic Interactions in Various Environmental Conditions in Caenorhabditis elegans |
title_fullStr | Genetic Interactions in Various Environmental Conditions in Caenorhabditis elegans |
title_full_unstemmed | Genetic Interactions in Various Environmental Conditions in Caenorhabditis elegans |
title_short | Genetic Interactions in Various Environmental Conditions in Caenorhabditis elegans |
title_sort | genetic interactions in various environmental conditions in caenorhabditis elegans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671385/ https://www.ncbi.nlm.nih.gov/pubmed/38003023 http://dx.doi.org/10.3390/genes14112080 |
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