Cargando…

Kaempferol: A Review of Current Evidence of Its Antiviral Potential

Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales: Periferakis, Argyrios, Periferakis, Aristodemos-Theodoros, Troumpata, Lamprini, Periferakis, Konstantinos, Scheau, Andreea-Elena, Savulescu-Fiedler, Ilinca, Caruntu, Ana, Badarau, Ioana Anca, Caruntu, Constantin, Scheau, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671393/
https://www.ncbi.nlm.nih.gov/pubmed/38003488
http://dx.doi.org/10.3390/ijms242216299
_version_ 1785149408647577600
author Periferakis, Argyrios
Periferakis, Aristodemos-Theodoros
Troumpata, Lamprini
Periferakis, Konstantinos
Scheau, Andreea-Elena
Savulescu-Fiedler, Ilinca
Caruntu, Ana
Badarau, Ioana Anca
Caruntu, Constantin
Scheau, Cristian
author_facet Periferakis, Argyrios
Periferakis, Aristodemos-Theodoros
Troumpata, Lamprini
Periferakis, Konstantinos
Scheau, Andreea-Elena
Savulescu-Fiedler, Ilinca
Caruntu, Ana
Badarau, Ioana Anca
Caruntu, Constantin
Scheau, Cristian
author_sort Periferakis, Argyrios
collection PubMed
description Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. However, the antiviral properties of kaempferol are notable, and there is a significant number of experimental studies on this topic. Kaempferol compounds were effective against DNA viruses such as hepatitis B virus, viruses of the alphaherpesvirinae family, African swine fever virus, and pseudorabies virus; they were also effective against RNA viruses, namely feline SARS coronavirus, dengue fever virus, Japanese encephalitis virus, influenza virus, enterovirus 71, poliovirus, respiratory syncytial virus, human immunodeficiency virus, calicivirus, and chikungunya virus. On the other hand, no effectiveness against murine norovirus and hepatitis A virus could be determined. The antiviral action mechanisms of kaempferol compounds are various, such as the inhibition of viral polymerases and of viral attachment and entry into host cells. Future research should be focused on further elucidating the antiviral properties of kaempferol compounds from different plants and assessing their potential use to complement the action of antiviral drugs.
format Online
Article
Text
id pubmed-10671393
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106713932023-11-14 Kaempferol: A Review of Current Evidence of Its Antiviral Potential Periferakis, Argyrios Periferakis, Aristodemos-Theodoros Troumpata, Lamprini Periferakis, Konstantinos Scheau, Andreea-Elena Savulescu-Fiedler, Ilinca Caruntu, Ana Badarau, Ioana Anca Caruntu, Constantin Scheau, Cristian Int J Mol Sci Review Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. However, the antiviral properties of kaempferol are notable, and there is a significant number of experimental studies on this topic. Kaempferol compounds were effective against DNA viruses such as hepatitis B virus, viruses of the alphaherpesvirinae family, African swine fever virus, and pseudorabies virus; they were also effective against RNA viruses, namely feline SARS coronavirus, dengue fever virus, Japanese encephalitis virus, influenza virus, enterovirus 71, poliovirus, respiratory syncytial virus, human immunodeficiency virus, calicivirus, and chikungunya virus. On the other hand, no effectiveness against murine norovirus and hepatitis A virus could be determined. The antiviral action mechanisms of kaempferol compounds are various, such as the inhibition of viral polymerases and of viral attachment and entry into host cells. Future research should be focused on further elucidating the antiviral properties of kaempferol compounds from different plants and assessing their potential use to complement the action of antiviral drugs. MDPI 2023-11-14 /pmc/articles/PMC10671393/ /pubmed/38003488 http://dx.doi.org/10.3390/ijms242216299 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Periferakis, Argyrios
Periferakis, Aristodemos-Theodoros
Troumpata, Lamprini
Periferakis, Konstantinos
Scheau, Andreea-Elena
Savulescu-Fiedler, Ilinca
Caruntu, Ana
Badarau, Ioana Anca
Caruntu, Constantin
Scheau, Cristian
Kaempferol: A Review of Current Evidence of Its Antiviral Potential
title Kaempferol: A Review of Current Evidence of Its Antiviral Potential
title_full Kaempferol: A Review of Current Evidence of Its Antiviral Potential
title_fullStr Kaempferol: A Review of Current Evidence of Its Antiviral Potential
title_full_unstemmed Kaempferol: A Review of Current Evidence of Its Antiviral Potential
title_short Kaempferol: A Review of Current Evidence of Its Antiviral Potential
title_sort kaempferol: a review of current evidence of its antiviral potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671393/
https://www.ncbi.nlm.nih.gov/pubmed/38003488
http://dx.doi.org/10.3390/ijms242216299
work_keys_str_mv AT periferakisargyrios kaempferolareviewofcurrentevidenceofitsantiviralpotential
AT periferakisaristodemostheodoros kaempferolareviewofcurrentevidenceofitsantiviralpotential
AT troumpatalamprini kaempferolareviewofcurrentevidenceofitsantiviralpotential
AT periferakiskonstantinos kaempferolareviewofcurrentevidenceofitsantiviralpotential
AT scheauandreeaelena kaempferolareviewofcurrentevidenceofitsantiviralpotential
AT savulescufiedlerilinca kaempferolareviewofcurrentevidenceofitsantiviralpotential
AT caruntuana kaempferolareviewofcurrentevidenceofitsantiviralpotential
AT badarauioanaanca kaempferolareviewofcurrentevidenceofitsantiviralpotential
AT caruntuconstantin kaempferolareviewofcurrentevidenceofitsantiviralpotential
AT scheaucristian kaempferolareviewofcurrentevidenceofitsantiviralpotential