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Kaempferol: A Review of Current Evidence of Its Antiviral Potential
Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. Ho...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671393/ https://www.ncbi.nlm.nih.gov/pubmed/38003488 http://dx.doi.org/10.3390/ijms242216299 |
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author | Periferakis, Argyrios Periferakis, Aristodemos-Theodoros Troumpata, Lamprini Periferakis, Konstantinos Scheau, Andreea-Elena Savulescu-Fiedler, Ilinca Caruntu, Ana Badarau, Ioana Anca Caruntu, Constantin Scheau, Cristian |
author_facet | Periferakis, Argyrios Periferakis, Aristodemos-Theodoros Troumpata, Lamprini Periferakis, Konstantinos Scheau, Andreea-Elena Savulescu-Fiedler, Ilinca Caruntu, Ana Badarau, Ioana Anca Caruntu, Constantin Scheau, Cristian |
author_sort | Periferakis, Argyrios |
collection | PubMed |
description | Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. However, the antiviral properties of kaempferol are notable, and there is a significant number of experimental studies on this topic. Kaempferol compounds were effective against DNA viruses such as hepatitis B virus, viruses of the alphaherpesvirinae family, African swine fever virus, and pseudorabies virus; they were also effective against RNA viruses, namely feline SARS coronavirus, dengue fever virus, Japanese encephalitis virus, influenza virus, enterovirus 71, poliovirus, respiratory syncytial virus, human immunodeficiency virus, calicivirus, and chikungunya virus. On the other hand, no effectiveness against murine norovirus and hepatitis A virus could be determined. The antiviral action mechanisms of kaempferol compounds are various, such as the inhibition of viral polymerases and of viral attachment and entry into host cells. Future research should be focused on further elucidating the antiviral properties of kaempferol compounds from different plants and assessing their potential use to complement the action of antiviral drugs. |
format | Online Article Text |
id | pubmed-10671393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106713932023-11-14 Kaempferol: A Review of Current Evidence of Its Antiviral Potential Periferakis, Argyrios Periferakis, Aristodemos-Theodoros Troumpata, Lamprini Periferakis, Konstantinos Scheau, Andreea-Elena Savulescu-Fiedler, Ilinca Caruntu, Ana Badarau, Ioana Anca Caruntu, Constantin Scheau, Cristian Int J Mol Sci Review Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. However, the antiviral properties of kaempferol are notable, and there is a significant number of experimental studies on this topic. Kaempferol compounds were effective against DNA viruses such as hepatitis B virus, viruses of the alphaherpesvirinae family, African swine fever virus, and pseudorabies virus; they were also effective against RNA viruses, namely feline SARS coronavirus, dengue fever virus, Japanese encephalitis virus, influenza virus, enterovirus 71, poliovirus, respiratory syncytial virus, human immunodeficiency virus, calicivirus, and chikungunya virus. On the other hand, no effectiveness against murine norovirus and hepatitis A virus could be determined. The antiviral action mechanisms of kaempferol compounds are various, such as the inhibition of viral polymerases and of viral attachment and entry into host cells. Future research should be focused on further elucidating the antiviral properties of kaempferol compounds from different plants and assessing their potential use to complement the action of antiviral drugs. MDPI 2023-11-14 /pmc/articles/PMC10671393/ /pubmed/38003488 http://dx.doi.org/10.3390/ijms242216299 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Periferakis, Argyrios Periferakis, Aristodemos-Theodoros Troumpata, Lamprini Periferakis, Konstantinos Scheau, Andreea-Elena Savulescu-Fiedler, Ilinca Caruntu, Ana Badarau, Ioana Anca Caruntu, Constantin Scheau, Cristian Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
title | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
title_full | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
title_fullStr | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
title_full_unstemmed | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
title_short | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
title_sort | kaempferol: a review of current evidence of its antiviral potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671393/ https://www.ncbi.nlm.nih.gov/pubmed/38003488 http://dx.doi.org/10.3390/ijms242216299 |
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