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Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine
This study is designed to formulate and characterize chitosan-based nanogels that provide the controlled delivery of anesthetic drugs, such as bupivacaine (BPV), for effective postoperative pain management over prolonged periods of time. Drug carriers of chitosan/poly (MMA-co-HEMA-cl-EGDMA) (CsPMH)...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671397/ https://www.ncbi.nlm.nih.gov/pubmed/38003661 http://dx.doi.org/10.3390/ijms242216470 |
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author | Nagella, Sivagangi Reddy Choi, Soojeong Park, Soo-Yong Ha, Chang-Sik Jung, Youngmi Chitumalla, Ramesh Kumar Jang, Joonkyung Yoon, Ji-Young Chung, Ildoo |
author_facet | Nagella, Sivagangi Reddy Choi, Soojeong Park, Soo-Yong Ha, Chang-Sik Jung, Youngmi Chitumalla, Ramesh Kumar Jang, Joonkyung Yoon, Ji-Young Chung, Ildoo |
author_sort | Nagella, Sivagangi Reddy |
collection | PubMed |
description | This study is designed to formulate and characterize chitosan-based nanogels that provide the controlled delivery of anesthetic drugs, such as bupivacaine (BPV), for effective postoperative pain management over prolonged periods of time. Drug carriers of chitosan/poly (MMA-co-HEMA-cl-EGDMA) (CsPMH) nanogels were prepared by varying the composition of comonomers such as MMA, HEMA, and redox initiator CAN. The nanogels were then characterized using FTIR, TGA, SEM, and TEM. The CsPMH nanogels showed greater encapsulation efficiencies from 43.20–91.77%. Computational studies were also conducted to evaluate the interaction between the drug and CsPMH nanoparticles. Finally, BPV-loaded nanoparticles were used to examine their in vitro release behavior. At pH 7.4, all the drug carriers displayed the “n” value around 0.7, thus the BPV release follows anomalous diffusion. Drug carrier 7 demonstrated a steady and sustained release of BPV for approximately 24 h and released about 91% of BPV, following the K-P mechanism of drug release. On the other hand, drug carrier 6 exhibited controlled release for approximately 12 h and released only 62% of BPV. |
format | Online Article Text |
id | pubmed-10671397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106713972023-11-17 Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine Nagella, Sivagangi Reddy Choi, Soojeong Park, Soo-Yong Ha, Chang-Sik Jung, Youngmi Chitumalla, Ramesh Kumar Jang, Joonkyung Yoon, Ji-Young Chung, Ildoo Int J Mol Sci Article This study is designed to formulate and characterize chitosan-based nanogels that provide the controlled delivery of anesthetic drugs, such as bupivacaine (BPV), for effective postoperative pain management over prolonged periods of time. Drug carriers of chitosan/poly (MMA-co-HEMA-cl-EGDMA) (CsPMH) nanogels were prepared by varying the composition of comonomers such as MMA, HEMA, and redox initiator CAN. The nanogels were then characterized using FTIR, TGA, SEM, and TEM. The CsPMH nanogels showed greater encapsulation efficiencies from 43.20–91.77%. Computational studies were also conducted to evaluate the interaction between the drug and CsPMH nanoparticles. Finally, BPV-loaded nanoparticles were used to examine their in vitro release behavior. At pH 7.4, all the drug carriers displayed the “n” value around 0.7, thus the BPV release follows anomalous diffusion. Drug carrier 7 demonstrated a steady and sustained release of BPV for approximately 24 h and released about 91% of BPV, following the K-P mechanism of drug release. On the other hand, drug carrier 6 exhibited controlled release for approximately 12 h and released only 62% of BPV. MDPI 2023-11-17 /pmc/articles/PMC10671397/ /pubmed/38003661 http://dx.doi.org/10.3390/ijms242216470 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nagella, Sivagangi Reddy Choi, Soojeong Park, Soo-Yong Ha, Chang-Sik Jung, Youngmi Chitumalla, Ramesh Kumar Jang, Joonkyung Yoon, Ji-Young Chung, Ildoo Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine |
title | Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine |
title_full | Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine |
title_fullStr | Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine |
title_full_unstemmed | Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine |
title_short | Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine |
title_sort | depolymerized chitosan-g-[poly(mma-co-hema-cl-egdma)] based nanogels for controlled local release of bupivacaine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671397/ https://www.ncbi.nlm.nih.gov/pubmed/38003661 http://dx.doi.org/10.3390/ijms242216470 |
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