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The AKI-to-CKD Transition: The Role of Uremic Toxins
After acute kidney injury (AKI), renal function continues to deteriorate in some patients. In a pro-inflammatory and profibrotic environment, the proximal tubules are subject to maladaptive repair. In the AKI-to-CKD transition, impaired recovery from AKI reduces tubular and glomerular filtration and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671582/ https://www.ncbi.nlm.nih.gov/pubmed/38003343 http://dx.doi.org/10.3390/ijms242216152 |
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author | André, Camille Bodeau, Sandra Kamel, Saïd Bennis, Youssef Caillard, Pauline |
author_facet | André, Camille Bodeau, Sandra Kamel, Saïd Bennis, Youssef Caillard, Pauline |
author_sort | André, Camille |
collection | PubMed |
description | After acute kidney injury (AKI), renal function continues to deteriorate in some patients. In a pro-inflammatory and profibrotic environment, the proximal tubules are subject to maladaptive repair. In the AKI-to-CKD transition, impaired recovery from AKI reduces tubular and glomerular filtration and leads to chronic kidney disease (CKD). Reduced kidney secretion capacity is characterized by the plasma accumulation of biologically active molecules, referred to as uremic toxins (UTs). These toxins have a role in the development of neurological, cardiovascular, bone, and renal complications of CKD. However, UTs might also cause CKD as well as be the consequence. Recent studies have shown that these molecules accumulate early in AKI and contribute to the establishment of this pro-inflammatory and profibrotic environment in the kidney. The objective of the present work was to review the mechanisms of UT toxicity that potentially contribute to the AKI-to-CKD transition in each renal compartment. |
format | Online Article Text |
id | pubmed-10671582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106715822023-11-10 The AKI-to-CKD Transition: The Role of Uremic Toxins André, Camille Bodeau, Sandra Kamel, Saïd Bennis, Youssef Caillard, Pauline Int J Mol Sci Review After acute kidney injury (AKI), renal function continues to deteriorate in some patients. In a pro-inflammatory and profibrotic environment, the proximal tubules are subject to maladaptive repair. In the AKI-to-CKD transition, impaired recovery from AKI reduces tubular and glomerular filtration and leads to chronic kidney disease (CKD). Reduced kidney secretion capacity is characterized by the plasma accumulation of biologically active molecules, referred to as uremic toxins (UTs). These toxins have a role in the development of neurological, cardiovascular, bone, and renal complications of CKD. However, UTs might also cause CKD as well as be the consequence. Recent studies have shown that these molecules accumulate early in AKI and contribute to the establishment of this pro-inflammatory and profibrotic environment in the kidney. The objective of the present work was to review the mechanisms of UT toxicity that potentially contribute to the AKI-to-CKD transition in each renal compartment. MDPI 2023-11-10 /pmc/articles/PMC10671582/ /pubmed/38003343 http://dx.doi.org/10.3390/ijms242216152 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review André, Camille Bodeau, Sandra Kamel, Saïd Bennis, Youssef Caillard, Pauline The AKI-to-CKD Transition: The Role of Uremic Toxins |
title | The AKI-to-CKD Transition: The Role of Uremic Toxins |
title_full | The AKI-to-CKD Transition: The Role of Uremic Toxins |
title_fullStr | The AKI-to-CKD Transition: The Role of Uremic Toxins |
title_full_unstemmed | The AKI-to-CKD Transition: The Role of Uremic Toxins |
title_short | The AKI-to-CKD Transition: The Role of Uremic Toxins |
title_sort | aki-to-ckd transition: the role of uremic toxins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671582/ https://www.ncbi.nlm.nih.gov/pubmed/38003343 http://dx.doi.org/10.3390/ijms242216152 |
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