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The AKI-to-CKD Transition: The Role of Uremic Toxins

After acute kidney injury (AKI), renal function continues to deteriorate in some patients. In a pro-inflammatory and profibrotic environment, the proximal tubules are subject to maladaptive repair. In the AKI-to-CKD transition, impaired recovery from AKI reduces tubular and glomerular filtration and...

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Autores principales: André, Camille, Bodeau, Sandra, Kamel, Saïd, Bennis, Youssef, Caillard, Pauline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671582/
https://www.ncbi.nlm.nih.gov/pubmed/38003343
http://dx.doi.org/10.3390/ijms242216152
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author André, Camille
Bodeau, Sandra
Kamel, Saïd
Bennis, Youssef
Caillard, Pauline
author_facet André, Camille
Bodeau, Sandra
Kamel, Saïd
Bennis, Youssef
Caillard, Pauline
author_sort André, Camille
collection PubMed
description After acute kidney injury (AKI), renal function continues to deteriorate in some patients. In a pro-inflammatory and profibrotic environment, the proximal tubules are subject to maladaptive repair. In the AKI-to-CKD transition, impaired recovery from AKI reduces tubular and glomerular filtration and leads to chronic kidney disease (CKD). Reduced kidney secretion capacity is characterized by the plasma accumulation of biologically active molecules, referred to as uremic toxins (UTs). These toxins have a role in the development of neurological, cardiovascular, bone, and renal complications of CKD. However, UTs might also cause CKD as well as be the consequence. Recent studies have shown that these molecules accumulate early in AKI and contribute to the establishment of this pro-inflammatory and profibrotic environment in the kidney. The objective of the present work was to review the mechanisms of UT toxicity that potentially contribute to the AKI-to-CKD transition in each renal compartment.
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spelling pubmed-106715822023-11-10 The AKI-to-CKD Transition: The Role of Uremic Toxins André, Camille Bodeau, Sandra Kamel, Saïd Bennis, Youssef Caillard, Pauline Int J Mol Sci Review After acute kidney injury (AKI), renal function continues to deteriorate in some patients. In a pro-inflammatory and profibrotic environment, the proximal tubules are subject to maladaptive repair. In the AKI-to-CKD transition, impaired recovery from AKI reduces tubular and glomerular filtration and leads to chronic kidney disease (CKD). Reduced kidney secretion capacity is characterized by the plasma accumulation of biologically active molecules, referred to as uremic toxins (UTs). These toxins have a role in the development of neurological, cardiovascular, bone, and renal complications of CKD. However, UTs might also cause CKD as well as be the consequence. Recent studies have shown that these molecules accumulate early in AKI and contribute to the establishment of this pro-inflammatory and profibrotic environment in the kidney. The objective of the present work was to review the mechanisms of UT toxicity that potentially contribute to the AKI-to-CKD transition in each renal compartment. MDPI 2023-11-10 /pmc/articles/PMC10671582/ /pubmed/38003343 http://dx.doi.org/10.3390/ijms242216152 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
André, Camille
Bodeau, Sandra
Kamel, Saïd
Bennis, Youssef
Caillard, Pauline
The AKI-to-CKD Transition: The Role of Uremic Toxins
title The AKI-to-CKD Transition: The Role of Uremic Toxins
title_full The AKI-to-CKD Transition: The Role of Uremic Toxins
title_fullStr The AKI-to-CKD Transition: The Role of Uremic Toxins
title_full_unstemmed The AKI-to-CKD Transition: The Role of Uremic Toxins
title_short The AKI-to-CKD Transition: The Role of Uremic Toxins
title_sort aki-to-ckd transition: the role of uremic toxins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671582/
https://www.ncbi.nlm.nih.gov/pubmed/38003343
http://dx.doi.org/10.3390/ijms242216152
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