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Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?

Cardiovascular diseases, especially ischemic heart disease, as a leading cause of heart failure (HF) and mortality, will not reduce over the coming decades despite the progress in pharmacotherapy, interventional cardiology, and surgery. Although patients surviving acute myocardial infarction live lo...

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Autores principales: Ravingerova, Tanya, Adameova, Adriana, Lonek, Lubomir, Farkasova, Veronika, Ferko, Miroslav, Andelova, Natalia, Kura, Branislav, Slezak, Jan, Galatou, Eleftheria, Lazou, Antigone, Zohdi, Vladislava, Dhalla, Naranjan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671596/
https://www.ncbi.nlm.nih.gov/pubmed/38003687
http://dx.doi.org/10.3390/ijms242216497
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author Ravingerova, Tanya
Adameova, Adriana
Lonek, Lubomir
Farkasova, Veronika
Ferko, Miroslav
Andelova, Natalia
Kura, Branislav
Slezak, Jan
Galatou, Eleftheria
Lazou, Antigone
Zohdi, Vladislava
Dhalla, Naranjan S.
author_facet Ravingerova, Tanya
Adameova, Adriana
Lonek, Lubomir
Farkasova, Veronika
Ferko, Miroslav
Andelova, Natalia
Kura, Branislav
Slezak, Jan
Galatou, Eleftheria
Lazou, Antigone
Zohdi, Vladislava
Dhalla, Naranjan S.
author_sort Ravingerova, Tanya
collection PubMed
description Cardiovascular diseases, especially ischemic heart disease, as a leading cause of heart failure (HF) and mortality, will not reduce over the coming decades despite the progress in pharmacotherapy, interventional cardiology, and surgery. Although patients surviving acute myocardial infarction live longer, alteration of heart function will later lead to HF. Its rising incidence represents a danger, especially among the elderly, with data showing more unfavorable results among females than among males. Experiments revealed an infarct-sparing effect of ischemic “preconditioning” (IPC) as the most robust form of innate cardioprotection based on the heart’s adaptation to moderate stress, increasing its resistance to severe insults. However, translation to clinical practice is limited by technical requirements and limited time. Novel forms of adaptive interventions, such as “remote” IPC, have already been applied in patients, albeit with different effectiveness. Cardiac ischemic tolerance can also be increased by other noninvasive approaches, such as adaptation to hypoxia- or exercise-induced preconditioning. Although their molecular mechanisms are not yet fully understood, some noninvasive modalities appear to be promising novel strategies for fighting HF through targeting its numerous mechanisms. In this review, we will discuss the molecular mechanisms of heart injury and repair, as well as interventions that have potential to be used in the treatment of patients.
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spelling pubmed-106715962023-11-18 Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart? Ravingerova, Tanya Adameova, Adriana Lonek, Lubomir Farkasova, Veronika Ferko, Miroslav Andelova, Natalia Kura, Branislav Slezak, Jan Galatou, Eleftheria Lazou, Antigone Zohdi, Vladislava Dhalla, Naranjan S. Int J Mol Sci Review Cardiovascular diseases, especially ischemic heart disease, as a leading cause of heart failure (HF) and mortality, will not reduce over the coming decades despite the progress in pharmacotherapy, interventional cardiology, and surgery. Although patients surviving acute myocardial infarction live longer, alteration of heart function will later lead to HF. Its rising incidence represents a danger, especially among the elderly, with data showing more unfavorable results among females than among males. Experiments revealed an infarct-sparing effect of ischemic “preconditioning” (IPC) as the most robust form of innate cardioprotection based on the heart’s adaptation to moderate stress, increasing its resistance to severe insults. However, translation to clinical practice is limited by technical requirements and limited time. Novel forms of adaptive interventions, such as “remote” IPC, have already been applied in patients, albeit with different effectiveness. Cardiac ischemic tolerance can also be increased by other noninvasive approaches, such as adaptation to hypoxia- or exercise-induced preconditioning. Although their molecular mechanisms are not yet fully understood, some noninvasive modalities appear to be promising novel strategies for fighting HF through targeting its numerous mechanisms. In this review, we will discuss the molecular mechanisms of heart injury and repair, as well as interventions that have potential to be used in the treatment of patients. MDPI 2023-11-18 /pmc/articles/PMC10671596/ /pubmed/38003687 http://dx.doi.org/10.3390/ijms242216497 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ravingerova, Tanya
Adameova, Adriana
Lonek, Lubomir
Farkasova, Veronika
Ferko, Miroslav
Andelova, Natalia
Kura, Branislav
Slezak, Jan
Galatou, Eleftheria
Lazou, Antigone
Zohdi, Vladislava
Dhalla, Naranjan S.
Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?
title Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?
title_full Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?
title_fullStr Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?
title_full_unstemmed Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?
title_short Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?
title_sort is intrinsic cardioprotection a laboratory phenomenon or a clinically relevant tool to salvage the failing heart?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671596/
https://www.ncbi.nlm.nih.gov/pubmed/38003687
http://dx.doi.org/10.3390/ijms242216497
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