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From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology

With the inexorable aging of the global populace, neurodegenerative diseases (NDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) pose escalating challenges, which are underscored by their socioeconomic repercussions. A pivotal aspect in addressing t...

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Autores principales: Toader, Corneliu, Dobrin, Nicolaie, Brehar, Felix-Mircea, Popa, Constantin, Covache-Busuioc, Razvan-Adrian, Glavan, Luca Andrei, Costin, Horia Petre, Bratu, Bogdan-Gabriel, Corlatescu, Antonio Daniel, Popa, Andrei Adrian, Ciurea, Alexandru Vlad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671641/
https://www.ncbi.nlm.nih.gov/pubmed/38003309
http://dx.doi.org/10.3390/ijms242216119
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author Toader, Corneliu
Dobrin, Nicolaie
Brehar, Felix-Mircea
Popa, Constantin
Covache-Busuioc, Razvan-Adrian
Glavan, Luca Andrei
Costin, Horia Petre
Bratu, Bogdan-Gabriel
Corlatescu, Antonio Daniel
Popa, Andrei Adrian
Ciurea, Alexandru Vlad
author_facet Toader, Corneliu
Dobrin, Nicolaie
Brehar, Felix-Mircea
Popa, Constantin
Covache-Busuioc, Razvan-Adrian
Glavan, Luca Andrei
Costin, Horia Petre
Bratu, Bogdan-Gabriel
Corlatescu, Antonio Daniel
Popa, Andrei Adrian
Ciurea, Alexandru Vlad
author_sort Toader, Corneliu
collection PubMed
description With the inexorable aging of the global populace, neurodegenerative diseases (NDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) pose escalating challenges, which are underscored by their socioeconomic repercussions. A pivotal aspect in addressing these challenges lies in the elucidation and application of biomarkers for timely diagnosis, vigilant monitoring, and effective treatment modalities. This review delineates the quintessence of biomarkers in the realm of NDs, elucidating various classifications and their indispensable roles. Particularly, the quest for novel biomarkers in AD, transcending traditional markers in PD, and the frontier of biomarker research in ALS are scrutinized. Emergent susceptibility and trait markers herald a new era of personalized medicine, promising enhanced treatment initiation especially in cases of SOD1-ALS. The discourse extends to diagnostic and state markers, revolutionizing early detection and monitoring, alongside progression markers that unveil the trajectory of NDs, propelling forward the potential for tailored interventions. The synergy between burgeoning technologies and innovative techniques like -omics, histologic assessments, and imaging is spotlighted, underscoring their pivotal roles in biomarker discovery. Reflecting on the progress hitherto, the review underscores the exigent need for multidisciplinary collaborations to surmount the challenges ahead, accelerate biomarker discovery, and herald a new epoch of understanding and managing NDs. Through a panoramic lens, this article endeavors to provide a comprehensive insight into the burgeoning field of biomarkers in NDs, spotlighting the promise they hold in transforming the diagnostic landscape, enhancing disease management, and illuminating the pathway toward efficacious therapeutic interventions.
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spelling pubmed-106716412023-11-09 From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology Toader, Corneliu Dobrin, Nicolaie Brehar, Felix-Mircea Popa, Constantin Covache-Busuioc, Razvan-Adrian Glavan, Luca Andrei Costin, Horia Petre Bratu, Bogdan-Gabriel Corlatescu, Antonio Daniel Popa, Andrei Adrian Ciurea, Alexandru Vlad Int J Mol Sci Review With the inexorable aging of the global populace, neurodegenerative diseases (NDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) pose escalating challenges, which are underscored by their socioeconomic repercussions. A pivotal aspect in addressing these challenges lies in the elucidation and application of biomarkers for timely diagnosis, vigilant monitoring, and effective treatment modalities. This review delineates the quintessence of biomarkers in the realm of NDs, elucidating various classifications and their indispensable roles. Particularly, the quest for novel biomarkers in AD, transcending traditional markers in PD, and the frontier of biomarker research in ALS are scrutinized. Emergent susceptibility and trait markers herald a new era of personalized medicine, promising enhanced treatment initiation especially in cases of SOD1-ALS. The discourse extends to diagnostic and state markers, revolutionizing early detection and monitoring, alongside progression markers that unveil the trajectory of NDs, propelling forward the potential for tailored interventions. The synergy between burgeoning technologies and innovative techniques like -omics, histologic assessments, and imaging is spotlighted, underscoring their pivotal roles in biomarker discovery. Reflecting on the progress hitherto, the review underscores the exigent need for multidisciplinary collaborations to surmount the challenges ahead, accelerate biomarker discovery, and herald a new epoch of understanding and managing NDs. Through a panoramic lens, this article endeavors to provide a comprehensive insight into the burgeoning field of biomarkers in NDs, spotlighting the promise they hold in transforming the diagnostic landscape, enhancing disease management, and illuminating the pathway toward efficacious therapeutic interventions. MDPI 2023-11-09 /pmc/articles/PMC10671641/ /pubmed/38003309 http://dx.doi.org/10.3390/ijms242216119 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Toader, Corneliu
Dobrin, Nicolaie
Brehar, Felix-Mircea
Popa, Constantin
Covache-Busuioc, Razvan-Adrian
Glavan, Luca Andrei
Costin, Horia Petre
Bratu, Bogdan-Gabriel
Corlatescu, Antonio Daniel
Popa, Andrei Adrian
Ciurea, Alexandru Vlad
From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology
title From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology
title_full From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology
title_fullStr From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology
title_full_unstemmed From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology
title_short From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology
title_sort from recognition to remedy: the significance of biomarkers in neurodegenerative disease pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671641/
https://www.ncbi.nlm.nih.gov/pubmed/38003309
http://dx.doi.org/10.3390/ijms242216119
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